
BCR-ABL Quantitative PCR (IS Scale) near me in Bareilly









The BCR-ABL Quantitative PCR (IS Scale) is a highly sensitive molecular blood test that measures the BCR-ABL gene (a genetic mutation linked to chronic myeloid leukemia [CML] and some blood cancers) and quantifies BCR-ABL p210 fusion transcript levels on an international scale (IS). It helps diagnose CML, monitor treatment effectiveness, and detect minimal residual disease, assess prognosis, and guide therapy adjustments. It is widely available with Tata 1mg labs at an affordable price in Bareilly.
The BCR-ABL Quantitative PCR (IS Scale) test is recommended for individuals diagnosed with CML. It is especially useful for individuals experiencing therapy resistance or treatment failure, as it detects mutations that may reduce the effectiveness of TKIs. Additionally, this test is important for monitoring treatment response over time, ensuring that the chosen therapy continues to work effectively. The results guide doctors in choosing the best treatment plan by showing which medicine is likely to work better based on the individual’s genetic profile.
Usually, no special preparation is needed for this test. Eat and drink as per the daily routine. However, it is preferred to provide the clinical history before giving the sample.








What does BCR-ABL Quantitative PCR (IS Scale) measure?
The BCR-ABL Quantitative PCR (IS Scale) test measures the amount of BCR-ABL fusion transcripts to diagnose chronic myeloid leukemia (CML) and Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL). This is used to monitor patient response to tyrosine kinase inhibitor (TKI) treatment. The test helps determine if treatment is effective, adjust medication, and monitor for disease recurrence or resistance. The test uses real-time quantitative PCR, which is highly sensitive and can detect even minute levels of residual disease. The results are reported on an International Scale (IS), which allows for standardization and comparability of results across different laboratories.
A low or undetectable level means the treatment is working well, while a higher or rising level may suggest relapse or resistance.





FAQs related to BCR-ABL Quantitative PCR (IS Scale) in Bareilly
- Kockerols CCB, Valk PJM, Levin MD, Pallisgaard N, Cornelissen JJ, Westerweel PE. Digital PCR for BCR-ABL1 Quantification in CML: Current Applications in Clinical Practice. Hemasphere. 2020 Nov 24;4(6):e496. [Accessed 8 May 2025]. Available from:
- Machado MP, Tomaz JP, Lorand-Metze I, de Souza CA, Vigorito AC, Delamain MT, Bendit I, Pereira NF, Pagnano KB. Monitoring of BCR-ABL levels in chronic myeloid leukemia patients treated with imatinib in the chronic phase - the importance of a major molecular response. Rev Bras Hematol Hemoter. 2011;33(3):211-5. [Accessed 8 May 2025]. Available from:
- Ayatollahi H, Keramati MR, Shirdel A, Kooshyar MM, Raiszadeh M, Shakeri S, Sadeghian MH. BCR-ABL fusion genes and laboratory findings in patients with chronic myeloid leukemia in northeast Iran. Caspian J Intern Med. 2018 Winter;9(1):65-70. [Accessed 8 May 2025]. Available from:
- Giri S, Pathak R, Martin MG, Bhatt VR. Characteristics and survival of BCR/ABL negative chronic myeloid leukemia: a retrospective analysis of the Surveillance, Epidemiology and End Results database. Ther Adv Hematol. 2015 Dec;6(6):3-12. [Accessed 8 May 2025]. Available from:
- Leukemia [Internet]. NIH: National Cancer Institute; [Accessed 8 May 2025]. Available from:
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