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Anti Thyroglobulin Antibody

Also known as Thyroglobulin antibody test
12091400 13% Off
You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. No special preparation is required.

Understanding Anti Thyroglobulin Antibody


What is Anti Thyroglobulin Antibody?

An Anti Thyroglobulin Antibody is a blood test that assesses the presence of specific antibodies targeting thyroglobulin, a protein produced by the thyroid gland. This test helps evaluate autoimmune thyroid disorders, particularly Hashimoto’s thyroiditis and Grave’s disease. 

Thyroglobulin is a key protein produced by the thyroid gland, a butterfly-shaped organ located in the neck. This protein helps in the production of thyroid hormones (T3, T4). It acts as a precursor in the thyroid hormone production process. After synthesis, thyroid hormones are released into the blood, where they regulate various physiological functions, including metabolism, energy production, and growth. 

Thyroglobulin is a target for antibodies in autoimmune thyroid conditions, and testing for anti-thyroglobulin (anti-TG) antibodies is often performed to assess the presence of autoimmune thyroid disease. The presence of anti-TG antibodies can indicate an autoimmune thyroid disorder such as Hashimoto’s thyroiditis or Graves' disease.

In Hashimoto’s thyroiditis, the immune system mistakenly targets and attacks the thyroid gland, leading to inflammation and potential damage. Grave’s disease, on the other hand, involves the production of antibodies that stimulate the thyroid gland, causing an overproduction of thyroid hormones. An Anti Thyroglobulin Antibody test helps in diagnosing and monitoring these conditions, providing insights into the autoimmune aspect of thyroid dysfunction. 

An Anti Thyroglobulin Antibody test is often performed alongside other tests such as TSH, T3, T4, and anti-thyroid peroxidase (anti-TPO) antibodies to provide a more comprehensive insight into thyroid function and to diagnose autoimmune thyroid disorders. It is a useful diagnostic test for understanding the role of the immune system in thyroid dysfunction and facilitating a tailored care approach for individuals with thyroid-related autoimmune conditions. 

If thyroid hormone tests indicate dysfunction, Anti Thyroglobulin Antibody test may be ordered to explore autoimmune causes. During pregnancy, an Anti Thyroglobulin Antibody test plays an important role in assessing thyroid health and identifying potential risks to the expecting mother and the growing baby. Also, for women with persistently elevated thyroid antibodies postpartum, there may be an increased risk of developing permanent hypothyroidism. 

Usually, no special preparation is required before undertaking a Anti Thyroglobulin Antibody test. However, if done alongside thyroid function tests (TSH, T3, T4), inform your doctor about medications or supplements you are taking. While maintaining the continuity of your thyroid medications, avoid biotin (Vitamin B7), an over-the-counter supplement two days before an Anti Thyroglobulin Antibody test, as it can impact the test results.

Lab test results may vary depending on your age, gender, health history, and other things. Abnormal test results require an expert interpretation; therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for a proper understanding of the test results. The insights from this test help the doctor to diagnose autoimmune thyroid disorders, guide treatment decisions, and assess thyroid health. 

What is Anti Thyroglobulin Antibody used for?

An Anti Thyroglobulin Antibody test is done: 

  • To diagnose autoimmune thyroid disease and its separation from other causes of thyroiditis.

  • To investigate the cause of goiter.

  • During follow-up of deranged thyroid hormones. 

  • To evaluate thyroid involvement in non-thyroid-related autoimmune disorders such as Rheumatoid arthritis (RA) and systemic lupus Erythematosus (SLE). 

  • To evaluate cases of pregnancy with autoimmune thyroid disorders like Hashimoto’s thyroiditis, Grave’s disease, etc.

  • To assess the risk of fetal involvement in case of pregnancy with thyroid dysfunction. 

  • As a part of the assessment of infertility.

What does Anti Thyroglobulin Antibody measure?

An Anti Thyroglobulin Antibody test measures the presence of antibodies directed against the protein thyroglobulin in the blood. These antibodies are called antithyroglobulin (anti-TG) antibodies that target the thyroid gland. Elevated levels of these antibodies indicate an autoimmune response against the thyroid, which can help diagnose autoimmune thyroid disorders like Hashimoto’s thyroiditis and Grave’s disease.

Monitoring the levels of these antibodies helps in the diagnosis, management, and understanding of autoimmune thyroid conditions, helping doctors formulate an appropriate care plan. 

Interpreting Anti Thyroglobulin Antibody results


Interpretations

The levels of anti-thyroglobulin antibody test should range <60.00 IU/mL.

Reference range may vary from lab to lab*

 

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Anti Thyroglobulin Antibody


Frequently Asked Questions about Anti Thyroglobulin Antibody

Q. What is an Anti Thyroglobulin Antibody test used for?

An Anti Thyroglobulin Antibody test is used to detect antibodies against thyroglobulin, a protein produced by the thyroid gland. Elevated levels of these antibodies may indicate autoimmune thyroid disorders, such as Hashimoto's thyroiditis and Graves' disease. This test helps in the diagnosis and management of thyroid-related conditions.

Q. Do I need to fast before an Anti Thyroglobulin Antibody test?

No, fasting is not required before an Anti Thyroglobulin Antibody test. You can eat and drink normally.

Q. How often should a Anti Thyroglobulin Antibody test be done?

The frequency of testing depends on the individual’s health condition and the doctor’s recommendations. It is typically ordered when assessing autoimmune thyroid disorders.

Q. Can an Anti Thyroglobulin Antibody test predict future thyroid dysfunction?

Yes, an Anti Thyroglobulin Antibody test can indicate an increased risk of future thyroid dysfunction. Elevated levels of anti-Thyroglobulin (anti-TG) antibodies may suggest an autoimmune response, providing valuable information that may predict the development of thyroid disorders over time.

Q. Can pregnancy affect anti-TG antibody levels?

Yes, pregnancy can affect the immune system and may cause changes in anti-TG antibody levels. It’s important for pregnant women with thyroid disorders to be monitored closely.

Q. What are autoimmune thyroid disorders?

The autoimmune thyroid disorders are those diseases that occur due to an attack of the body’s immune system on the thyroid gland. Examples of autoimmune thyroid diseases include Hashimoto’s thyroiditis, Grave’s disease, etc.

Q. What is Grave’s disease?

Grave’s disease is an autoimmune disorder. In this disease, the immune system of the body attacks the thyroid gland causing excessive production of thyroid hormone leading to hyperthyroidism (overactive thyroid).

Q. What is Hashimoto’s thyroiditis?

Hashimoto’s disease is an autoimmune disorder that can cause hypothyroidism or underactive thyroid. In this condition, there is a chronic inflammation of the thyroid gland. Rarely, Hashimoto’s thyroiditis can cause hyperthyroidism or overactive thyroid.
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Anti Thyroglobulin Antibody test price for other cities


Price inBangaloreRs. 1209
Price inMumbaiRs. 1209
Price inGurgaonRs. 1209
Price inHyderabadRs. 1209
Price inKolkataRs. 1209
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References

  1. Fröhlich E, Wahl R. Thyroid Autoimmunity: Role of Anti-thyroid Antibodies in Thyroid and Extra-Thyroidal Diseases. Front Immunol. 2017 May 9;8:521. [Accessed 13 Feb. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422478/ External Link
  2. Tipu HN, Ahmed D, Bashir MM, Asif N. Significance of Testing Anti-Thyroid Autoantibodies in Patients with Deranged Thyroid Profile. J Thyroid Res. 2018 Apr 11;2018:9610497. [Accessed 13 Feb. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925209/ External Link
  3. Swain M, Swain T, Mohanty BK. Autoimmune thyroid disorders-An update. Indian J Clin Biochem. 2005 Jan;20(1):9-17. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454167/ External Link
  4. Franco JS, Amaya-Amaya J, Anaya JM. Thyroid disease and autoimmune diseases. In: Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al., editors. Autoimmunity: From Bench to Bedside [Internet]. Bogota (Colombia): El Rosario University Press; 2013 Jul 18. Chapter 30. [Accessed 13 Feb. 2024]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459466/ External Link
  5. Hashimoto’s Disease. [Internet]. NIH; Jun. 2021. [Accessed 13 Feb. 2024]. Available from: https://www.niddk.nih.gov/health-information/endocrine-diseases/hashimotos-disease External Link
  6. Grave’s Disease. [Internet]. NIH; Nov. 2021. [Accessed 13 Feb. 2024]. Available from: https://www.niddk.nih.gov/health-information/endocrine-diseases/graves-disease External Link
  7. Thyroid Antithyroglobulin Antibody [Internet] Rochester, NY: University of Rochester Medical Center; [Accessed 13 Feb. 2024]. Available from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=thyroid_antithyroglobulin_antibody External Link
  8. Jo K, Lim DJ. Clinical implications of anti-thyroglobulin antibody measurement before surgery in thyroid cancer. Korean J Intern Med. 2018 Nov;33(6):1050-1057. [Accessed 13 Feb. 2024]. Available from: https://pubmed.ncbi.nlm.nih.gov/30396251/ External Link
  9. Jiang N, Jiao B, Zhang L, Li J, Li Y, Lin C. Application of thyroglobulin and anti-thyroglobulin antibody combined with emission computed tomography in the adjuvant diagnosis of differentiated thyroid carcinoma. Ann Med. 2023 Dec;55(1):2232372. [Accessed 13 Feb. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339774/ External Link
  10. Latif Z, Crupie MJ. Aberrant Thyroid Function Tests in a Patient Taking Biotin Supplements. Cureus. 2019 Aug 1;11(8):e5297. [Accessed 13 Feb. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768618/ External Link
  11. Ringel MD, Nabhan F. Approach to follow-up of the patient with differentiated thyroid cancer and positive anti-thyroglobulin antibodies. J Clin Endocrinol Metab. 2013 Aug;98(8):3104-10. [Accessed 13 Feb. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733852/ External Link
  12. Xi C, Zhang GQ, Song HJ, Shen CT, Hou LY, Qiu ZL, Luo QY. Change in Antithyroglobulin Antibody Levels is a Good Predictor of Responses to Therapy in Antithyroglobulin Antibody-Positive Pediatric Papillary Thyroid Carcinoma Patients. Int J Endocrinol. 2022 Mar 10;2022:7173919. [Accessed 13 Feb. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930237/#:~:text=Antithyroglobulin%20antibodies%20(TgAbs)%20may%20be,DTC%20%5B5%2C%206%5D. External Link

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