Anti - dsDNA Antibody (Double Stranded, Native) in Dilutions by IFA

Anti-dsDNA (anti-double-stranded DNA) antibodies are a type of autoantibody that mistakenly targets the body’s own DNA inside the cell’s nucleus. These antibodies form as a result of the immune system wrongly identifying the body’s own DNA as a threat. It is often seen in autoimmune diseases like systemic lupus erythematosus (SLE). The presence of anti-dsDNA antibodies causes inflammation and damage to various organs, signaling an immune system malfunction.

The Anti - dsDNA Antibody (Double Stranded, Native) in Dilutions by IFA test is performed when an individual experiences symptoms associated with SLE. Symptoms may include joint pain and stiffness, skin rashes, butterfly-shaped rash on the face, kidney dysfunction, unexplained fever, etc. This test is particularly done when an individual has a positive antinuclear antibody (ANA) test. It also helps in monitoring disease activity and progression in patients already diagnosed with SLE. It also helps assess the risk of lupus development in individuals with a family history of the disease. This test is also done to distinguish SLE from other autoimmune disorders sharing similar signs and symptoms.

For this test, a blood sample is diluted and examined using a method called IFA to look for anti-dsDNA antibodies. The result shows how much the blood can be diluted and still detect these antibodies. High levels may suggest lupus (SLE), but results should be considered along with symptoms and medical history. Low levels of these antibodies can also appear in other diseases like Sjögren’s syndrome, rheumatoid arthritis, and mixed connective tissue disease. Hence, the results need to be interpreted carefully with other information.

No special preparation is required for this test. Inform the doctor about all the medications or supplements being taken, as well as the medical history, as these factors could potentially affect the test results.  

Test result ranges may vary across laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results. Always consult a doctor for a proper understanding of the test results.