Anti - dsDNA Antibody (Double Stranded, Native) by IFA

Anti-dsDNA (anti-double-stranded DNA) antibodies are a type of autoantibody that targets the body’s own DNA inside the cell’s nucleus. These antibodies are produced when the immune system mistakenly attacks the body’s own DNA. It is often seen in autoimmune diseases like systemic lupus erythematosus (SLE). The presence of anti-dsDNA antibodies causes inflammation and damage to various organs, signaling an immune system malfunction.

The Anti - dsDNA Antibody (Double Stranded, Native) by IFA test is performed when an individual experiences symptoms associated with SLE. Symptoms may include joint pain and stiffness, skin rashes, a butterfly-shaped rash on the face, kidney dysfunction, unexplained fever, etc. This test is particularly done when an individual has a positive antinuclear antibody (ANA) test. It can help track the disease in individuals already diagnosed with SLE and also check the risk in those with a family history SLE. It also helps tell lupus apart from other autoimmune conditions with similar symptoms.

The Anti - dsDNA Antibody (Double Stranded, Native) by IFA test uses a special method called Immunofluorescence Assay (IFA). This method helps detect antibodies in the blood using dyes to show if the antibodies are targeting the body's DNA.

A positive result means anti-dsDNA antibodies are present, which are common in lupus (SLE). However, it should be considered along with the patient's medical history. A negative result means no antibodies were found, but it doesn’t completely rule out lupus, as some people may have low levels that can’t be detected. Low to moderate levels of these antibodies can also appear in other conditions, like Sjögren’s syndrome or mixed connective tissue disease. So, the result should be correlated with symptoms, medical history, and additional tests.

No special preparation is required for this test. Inform the doctor about all the medications or supplements being taken, as well as the medical history, as these factors could potentially affect the test results.  

Test result ranges may vary across laboratories. Abnormal test results require an expert interpretation. Never try to self-medicate at home based solely on these results, and always consult a doctor for a proper understanding of the test results.