Ceruloplasmin

Ceruloplasmin is a protein produced by the liver that helps transport and store copper through the blood. About 65% to 90% of the copper in the blood is carried by ceruloplasmin. Copper is important for many body functions, like building strong bones and making skin pigment (melanin). 

Normally, the liver extracts copper from the blood and binds it to the ceruloplasmin protein. The ceruloplasmin is then released into the blood, transporting copper to various body parts.  The Ceruloplasmin test provides important insights into how the body stores and uses copper. 

The Ceruloplasmin test may be recommended if there are symptoms such as fatigue, jaundice, tremors, difficulty speaking or swallowing, changes in behavior, or signs of liver dysfunction. Doctors also use this test to diagnose conditions that can result in copper deficiency. These conditions may include malnutrition (lack of copper in the diet), malabsorption (inefficient absorption of copper in the digestive tract), too much dietary zinc (competes with copper for absorption), and Menkes disease (a genetic disease affecting copper absorption). This test is also done if there is a family history of Wilson's disease.

Usually, overnight fasting is preferred for getting tested. It is important to inform the doctor of any medications, supplements, or hormonal therapies being taken, as these can influence results.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate and always consult a doctor to understand the test results correctly.