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Zupion-DX Tablet

Bupropion (105mg)+ Dextromethorphan Hydrobromide (45mg)

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Zupion-DX Tablet is a combination of two medicines used in the treatment of depression. It works by increasing certain chemicals in the brain to help improve mood and reduce symptoms of depression. This way it can help lift mood and enhance overall emotional well-being.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 07 Apr 2026 | 02:54 PM (IST)

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10 tablets

Gurgaon

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General Information

Contains

Bupropion (105mg)+ Dextromethorphan Hydrobromide (45mg)

Marketer

Intas Pharmaceuticals Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Take Zupion-DX Tablet as prescribed by your doctor. It may be taken with or without food. To get the maximum benefit, take the tablet at the same time each day to help you remember. Do not crush, chew, or break the tablet; swallow it whole. Follow your doctor’s instructions and not to stop taking the medication suddenly without consulting your doctor, as this can affect your treatment.

Common side effects of Zupion-DX Tablet include dizziness, headache, diarrhea, somnolence, dry mouth, sexual dysfunction, and excessive sweating. If you experience these side effects, they are often mild and may go away as your body adjusts to the medication. Drinking plenty of fluids and eating small, frequent meals can help manage nausea. If the side effects persist or worsen, contact your doctor. They can provide advice or adjust your treatment if needed.

Avoid consuming alcohol while taking Zupion-DX Tablet, as it can increase the risk of serious side effects. Be cautious when driving or operating machinery, as the medication may cause dizziness or drowsiness. Inform your doctor of any other medications or supplements you are taking to prevent interactions.

Do not use Zupion-DX Tablet if you have a history of seizures or eating disorders, or if you are taking certain other medications, as these conditions or interactions could be dangerous. Always discuss your medical history and current health conditions with your healthcare provider before starting treatment. Pregnant or breastfeeding women should not take this medicine without proper consultation with their doctors.

Uses of Zupion-DX Tablet

Treatment of Depression

Benefits of Zupion-DX Tablet

Treatment of Depression
Zupion-DX Tablet helps treat depression by improving mood, increasing energy levels, and reducing core depressive symptoms like persistent sadness and fatigue. It enhances brain chemistry, leading to better cognitive function and overall functionality. This can improve the emotional well-being and quality of life, supporting individuals in managing their daily activities and relationships more effectively.

Side effects of Zupion-DX Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Zupion-DX

Dizziness
Headache
Diarrhea
Sleepiness
Dryness in mouth
Sexual dysfunction
Sweating

How to use Zupion-DX Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zupion-DX Tablet may be taken with or without food.

How Zupion-DX Tablet works

Zupion-DX Tablet contains two ingredients. Dextromethorphan hydrobromide can block specific signals in the brain that are often overactive in people with depression. By doing this, it may help calm the brain down and improve mood. It also activates certain brain receptors that help regulate mood and protect the brain. This can help balance the chemicals in your brain that affect how you feel. Bupropion increases the levels of certain chemicals in the brain, specifically dopamine and norepinephrine. These chemicals are involved in mood regulation, and by increasing their levels, bupropion can help improve mood and feelings of well-being.

All substitutes for Zupion-DX Tablet

For information purposes only. Consult a doctor before taking any medicine.

Buprojoy Tablet

by Alkem Laboratories Ltd

₹17/tablet

67% costlier

Bropidex 105mg/45mg Tablet

by La Renon Healthcare Pvt Ltd

₹10.1/tablet

1% cheaper

Quick tips

Take Zupion-DX Tablet at the same time each day to maintain consistent levels of the medication in your system and to help you remember to take it.
Refrain from consuming alcohol while on this medication, as it can increase the risk of side effects and diminish the effectiveness of the treatment.
Drink plenty of fluids to help manage common side effects like dry mouth and nausea.
Attend all follow-up appointments with your doctor to monitor your progress and make any necessary adjustments to your treatment.
Be mindful of activities that require concentration, such as driving, until you know how Zupion-DX Tablet affects you, as it may cause dizziness or drowsiness.
Do not stop taking Zupion-DX Tablet suddenly without consulting your doctor, as this can affect your treatment and health.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Zupion-DX Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

UNSAFE

Zupion-DX Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

UNSAFE

Zupion-DX Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Zupion-DX Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Zupion-DX Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

UNSAFE

Zupion-DX Tablet is unsafe to use in patients with liver disease and should be avoided.

Frequently asked questions

What is Zupion-DX Tablet used for?

Zupion-DX Tablet is used to treat major depressive disorder (MDD). It helps improve mood, increase energy levels, and reduce symptoms of depression by altering brain chemistry.

How should I take Zupion-DX Tablet?

Take Zupion-DX Tablet exactly as prescribed by your doctor. It is typically taken once daily, with or without food. Swallow the tablet whole; do not crush, chew, or break it.

How long does it take to feel the effects of Zupion-DX Tablet?

It may take several weeks to start noticing improvements in your mood and symptoms. Continue taking the medication as prescribed and keep your follow-up appointments to monitor progress.

Can I drink alcohol while taking Zupion-DX Tablet?

No, you should avoid alcohol while taking Zupion-DX Tablet as it can increase the risk of serious side effects.

Can Zupion-DX Tablet interact with other medications?

Yes, Zupion-DX Tablet can interact with other medications. Always inform your doctor about all the medications, including over-the-counter drugs and supplements, that you are taking.

Can I stop taking Zupion-DX Tablet suddenly?

Do not stop taking Zupion-DX Tablet abruptly without consulting your doctor, as this can affect your treatment. Your doctor will guide you on how to safely discontinue the medication if needed.

Fact Box

Habit Forming

Therapeutic Class

NEURO CNS

References

Dextromethorphan hydrobromide and bupropion hydrochloride [Prescribing Information]. New York, NY: Axsome Therapeutics, Inc.; 2022. [Accessed 31 Jul. 2024] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Zupion-DX Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Zupion-DX Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Zupion-DX Tablet

Benefits of Zupion-DX Tablet

Side effects of Zupion-DX Tablet

How to use Zupion-DX Tablet

How Zupion-DX Tablet works

All substitutes for Zupion-DX Tablet

Buprojoy Tablet

Bropidex 105mg/45mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Zupion-DX Tablet used for?

How should I take Zupion-DX Tablet?

How long does it take to feel the effects of Zupion-DX Tablet?

Can I drink alcohol while taking Zupion-DX Tablet?

Can Zupion-DX Tablet interact with other medications?

Can I stop taking Zupion-DX Tablet suddenly?

Fact Box

Habit Forming

Therapeutic Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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