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Zoly 0.5mg/10mg Tablet 1
Zoly 0.5mg/10mg Tablet 2
Not for online sale
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required
Zoly 0.5mg/10mg Tablet is a combination of two medicines used in the treatment of schizophrenia, a mental disorder that can result in hallucinations or delusions. It alters the thoughts and elevates the mood, improving the person’s ability to think, feel and behave.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 31 Aug 2026 | 02:52 PM (IST)
₹63.3 MRP ₹70.3110% off 
We do not facilitate sale of this product at present
(Inclusive of applicable taxes)
Gurgaon
 
 
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General Information

Contains

Flupenthixol (0.5mg)+ Nortriptyline (10mg)

Marketer

Man Serve Pharma

Storage

Store below 30°C
The content is shown in English
Zoly 0.5mg/10mg Tablet 1
Zoly 0.5mg/10mg Tablet 2

Product introduction

Zoly 0.5mg/10mg Tablet may be taken with or without food, preferably at the same time each day. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember it. Do not skip any doses and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to your doctor as it may worsen your symptoms.

Some common side effects of this medicine include dry mouth, constipation, urinary retention, blurred vision, increased heart rate, muscle rigidity, restlessness, and tremor. Initially, this medicine may cause a sudden drop in blood pressure when you change positions, rise slowly if you have been sitting or lying down. It may also cause dizziness and sleepiness, do not drive or do anything that requires mental focus until you know how this medicine affects you.

Before taking it, inform your doctor if you are suffering from thyroid or kidney disease, epilepsy, Parkinson’s disease, glaucoma, or any heart disease. You should not take this medicine if you are under the influence of alcohol or any sleep-inducing, cough, and/ or allergy medication. This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly.

Uses of Zoly Tablet

Benefits of Zoly Tablet

Schizophrenia
Schizophrenia is a mental disorder in which a person’s thinking ability, feelings and behavior become abnormal. Zoly 0.5mg/10mg Tablet helps restore the chemical imbalances in the brain that are responsible for such changes. It improves thoughts, behavior and enhances the quality of life.

Side effects of Zoly Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Zoly
  • Dryness in mouth
  • Constipation
  • Weight gain
  • Sleepiness
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Urinary retention
  • Increased prolactin level in blood
  • Blurred vision
  • Increased heart rate
  • Muscle stiffness
  • Restlessness
  • Tremors

How to use Zoly Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zoly 0.5mg/10mg Tablet may be taken with or without food.

How Zoly Tablet works

Zoly 0.5mg/10mg Tablet is a combination of two medicines: Flupenthixol and Nortriptyline which have anxiety-lowering and mood-elevating effects. Flupenthixol is a typical antipsychotic. It works by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts and mood. Nortriptyline is a tricyclic antidepressant which increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.

Quick tips

  • Zoly 0.5mg/10mg Tablet helps treat anxiety and depression.
  • Use caution while driving or doing anything that requires concentration as Zoly 0.5mg/10mg Tablet can cause dizziness and sleepiness.
  • Avoid drinking alcohol while taking this medicine because it can make drowsiness worse.
  • It can cause changes in your blood sugar levels. Monitor your blood sugar regularly.
  • Inform your doctor if you have liver disease, thyroid disorder, severe heart disease, or a urinary disorder.
  • Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
  • Let your doctor know you are taking Zoly 0.5mg/10mg Tablet before undergoing any surgical procedure.

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Zoly 0.5mg/10mg Tablet may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Zoly 0.5mg/10mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

UNSAFE
Zoly 0.5mg/10mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

UNSAFE
Zoly 0.5mg/10mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
As Zoly 0.5mg/10mg Tablet may affect your alertness which may affect your ability to drive.
Kidney

Kidney

CAUTION
Zoly 0.5mg/10mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
However, there have been reports of some side effects in patients with severe kidney disease.
Liver

Liver

CAUTION
Zoly 0.5mg/10mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.
Inform your doctor if you develop any signs and symptoms of jaundice while taking this medicine. Use of Zoly 0.5mg/10mg Tablet is not recommended in patients with severe liver disease.
All

Frequently asked questions

Zoly 0.5mg/10mg Tablet is usually given to help manage symptoms of depression that occur along with anxiety, tension, restlessness, or excessive worrying. These symptoms can affect relationships, work, sleep, and daily activities. By improving mood and reducing anxiety, the medicine may help you feel more emotionally balanced and better able to cope with everyday life.
Zoly 0.5mg/10mg Tablet contains Flupenthixol and Nortriptyline, which work on chemical messengers in the brain that influence mood, emotions, and stress responses. When these chemicals become imbalanced, a person may experience persistent sadness, anxiety, irritability, or loss of interest in activities. The medicine helps restore this balance and gradually improves emotional well-being.
Yes. Many people with anxiety find it difficult to stop worrying, even about everyday situations. They may repeatedly think about problems or imagine negative outcomes. As treatment starts working, these thoughts often become less overwhelming, making it easier to relax and focus on daily tasks.
Anxiety does not always have an obvious trigger. Sometimes it can occur because of changes in brain chemicals that affect how stress and emotions are processed. This may cause constant nervousness, restlessness, or a feeling that something bad might happen even when there is no clear reason for concern.
Loss of interest in hobbies, social activities, work, or spending time with loved ones is a common symptom of depression. As your mood improves, you may gradually regain interest in activities that once felt enjoyable. This improvement is usually gradual rather than sudden.
Depression can sometimes make individuals feel emotionally flat, detached, or unable to experience happiness, excitement, or affection in the same way as before. As treatment progresses, many people notice that they become more emotionally engaged and responsive to the people and activities around them.
Yes. Depression does not only affect mood. It can also cause tiredness, low energy, poor concentration, body aches, headaches, changes in appetite, and disturbed sleep. Because of this, some people initially think they have a physical illness rather than a mental health condition.
Some individuals may feel sleepy, tired, or less alert, especially during the first few weeks of treatment. This happens because Nortriptyline can affect brain pathways involved in wakefulness. The sleepiness often becomes less noticeable as your body adjusts to the medicine.
Dry mouth is a common effect of Nortriptyline. The medicine can reduce saliva production, which may leave your mouth feeling dry or sticky. Drinking water regularly, chewing sugar-free gum, and maintaining good oral hygiene may help reduce discomfort.
Yes. While Zoly 0.5mg/10mg Tablet can help manage anxiety and depression, stressful life events can still affect your emotional well-being. Work pressure, relationship difficulties, financial concerns, or poor sleep may temporarily worsen symptoms. Learning healthy coping strategies alongside treatment may help improve recovery.
Treatment often works best when combined with healthy lifestyle habits. Regular physical activity, a consistent sleep schedule, balanced meals, stress-management techniques, and staying connected with supportive friends or family members can all contribute to emotional recovery.
Many people begin to feel better before the underlying condition is fully controlled. Continuing treatment for the duration recommended by your doctor helps stabilize improvement and may reduce the likelihood of symptoms returning in the future.
They can. Factors such as ongoing stress, major life changes, poor sleep, or stopping treatment too early may increase the chance of symptoms returning. Recognizing early warning signs and seeking help promptly can make symptoms easier to manage.
Contact your doctor if your symptoms are getting worse, if you experience severe sleepiness, major mood changes, worsening anxiety, unusual thoughts, difficulty carrying out daily activities, or side effects that are affecting your quality of life. Regular follow-up helps ensure the treatment remains safe and effective.

Fact Box

Habit Forming

No

Therapeutic Class

NEURO CNS

References

  1. Flupenthixol. Everard Close, Abbey View St Albans: Lundbeck Limited; 1982 [revised Dec. 2016]. [Accessed 30 Apr. 2019] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Man Serve Pharma
Address: No. 62, Kamdhenu Shopping Centre, Near Peetal Factory, Shastri Nagar, Jaipur - 302 016, Rajasthan, India

Vendor Details

Country of origin: India

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