Zoline-M Tablet is a medicine used in the treatment of depression, panic disorder, anxiety disorder, obsessive-compulsive disorder, post-traumatic stress disorder, and premenstrual dysphoric disorder. It helps calms the brain and improves the mood and physical symptoms of the disease.

Zoline-M Tablet may be taken with or without food. Take it regularly and at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the exact dose and duration as advised by your doctor. If you have missed a dose, take it as soon as you remember it and finish the full course of treatment even if you feel better. You should not stop this medicine suddenly without talking to the doctor.

Some common side effects of this medicine include dizziness, dry mouth, palpitations, and memory impairment. It is important to inform your doctor if you develop any unusual changes in mood or depression as this medicine may cause suicidal thoughts.

Uses of Zoline-M Tablet

Benefits of Zoline-M Tablet

In Treatment of Depression

Zoline-M Tablet helps in maintaining the level of certain chemicals (such as serotonin) in the brain that affect mood and behavior. This creates a feeling of wellbeing, may help restore your interest in daily living and increases your energy levels. With Zoline-M Tablet, you may experience fewer episodes of depression and low mood. Exercise and a healthy diet can also improve your mood. Take Zoline-M Tablet exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

In Anxiety disorder

Zoline-M Tablet helps relieve symptoms of anxiety disorder by increasing the level of a natural chemical (serotonin) in the brain. It may decrease fear, unwanted thoughts, tension, restlessness, calms your mind and helps you sleep well. Keep taking the medicine until your doctor advises you to stop. Regular meditation and yoga can help relax your mind and body.

In Obsessive-compulsive disorder

Obsessive-compulsive disorder is a mental condition in which people have unwanted and repeated thoughts, feelings, ideas, sensations (obsessions) or the urge to do something over and over again (compulsions). These obsessions and compulsions can interfere with your daily activities. Zoline-M Tablet helps in treating the symptoms of Obsessive-compulsive disorder and thus improves the quality of your life.

In Post traumatic stress disorder

Post-traumatic stress disorder (PTSD) is a disorder that develops in some people who have experienced a shocking, frightening, or stressful event. Symptoms may include nightmares, flashbacks of the terrifying event, or severe anxiety. Zoline-M Tablet helps decrease fear, anxiety, unwanted thoughts and improves sleep. It also prevents extreme changes in mood and helps you feel less agitated.

In Panic disorder

With Zoline-M Tablet, you may feel less afraid or anxious and have fewer panic attacks (sudden, unexpected attacks of extreme fear and worry). It can help you feel calmer and improve your ability to deal with problems. Do not stop taking it, even when you feel better unless your doctor advises you to. Change in diet and lifestyle can help overcome panic attacks.

In Premenstrual dysphoric disorder

Premenstrual dysphoric disorder (PMDD) is a condition in which a woman has severe depression symptoms, irritability, anger and tension before her periods (menstruation). Zoline-M Tablet helps you feel calm and improves your mood. It works by increasing the amounts of a natural substance in the brain (serotonin) that helps maintain mental balance. Indulging in some relaxation therapy, meditation and yoga might also provide you relief.

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Side effects of Zoline-M Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Zoline-M

Dizziness
Dryness in mouth
Palpitations
Memory impairment

How to use Zoline-M Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zoline-M Tablet may be taken with or without food.

How Zoline-M Tablet works

Zoline-M Tablet is a combination of two medicines : Sertraline and Clonazepam. Sertraline is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the levels of serotonin, a chemical messenger in the brain. This improves mood and physical symptoms of depression and also relieves symptoms of post traumatic stress disorder, obsessive-compulsive disorder, panic disorder, premenstrual dysphoric disorder and anxiety. Clonazepam is a benzodiazepine. It works by increasing the action of a chemical messenger (GABA) which suppresses the abnormal and excessive activity of the nerve cells in the brain.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Zoline-M Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

Zoline-M Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

UNSAFE

Zoline-M Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Zoline-M Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Zoline-M Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

UNSAFE

Zoline-M Tablet is unsafe to use in patients with liver disease and should be avoided.

What if you forget to take Zoline-M Tablet?

If you miss a dose of Zoline-M Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

No substitutes found for this medicine

Quick tips

You have been prescribed Zoline-M Tablet in order to improve your mental health and manage your depression, anxiety, mood disorders.
You may feel that Zoline-M Tablet is not helping you straightaway. This is because it can take few weeks before you feel the full benefit. It is important that you continue to take it.
Inform your doctor immediately if you get thoughts about harming yourself or ending your life.
Avoid taking antacids 2 hours before or after taking Zoline-M Tablet as they make it harder for your body to absorb the medicine.
If you have diabetes, you will be asked to monitor your blood glucose level regularly as this medicine may affect the levels of sugar in your blood.
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.

Fact Box

Habit Forming

Therapeutic Class

NEURO CNS

Patient concerns

I have Obsessive compulsive Disorder. Prescribe the medication.

Dr. Deepak Kumar Soni

Ayurveda

Hi Kindly share your symptoms of your Problem

how to tackle depression and post traumal stress disorder?

Dr. Jyoti Kapoor Madan

Psychiatry

Psychiatric evaluation is based on history, clinical symptoms, personality factors, ongoing psychosocial stressors and frequency and severity of symptoms. It requires direct interaction with the patient on a regular basis. Once diagnosed, a management plan is formed based on intensity and frequency of symptoms and associated biological and psycho social factors. A complete solution to ones problems in a single question is thus not possible. Internet will give you generalised tips and tricks but they are hardly of any use. I suggest you to visit a psychiatrist in your vicinity for clinical evaluation.

Mental Depression , Anxiety disorder

Dr. Jyoti Kapoor Madan

Psychiatry

Depression is a persistent state of sadness that is the result of interaction between one's inner biological and psychological state and gets triggered of with environmental stressors. Reactive depression is in response to a situation like loss, sickness, trauma etc. Endogenous depression occurs without any noticeable environmental stressors. Psychological symptoms include lack of interest, negative thinking, irritability, frustration, feeling demotivated etc. Somatic symptoms like fatigue/ weakness/ lack of sleep/ lack of appetite and other physical symptoms are common. Anxiety is common. In severe cases one may feel helpless and hopeless enough to wish for death or attempt suicide. Treatment includes physical and psychiatric work up following which medicines can be prescribed. In milder cases, psychotherapy or counselling is recommended.

PANIC ATTACK ANXIETY DISORDER T

Dr. Jyoti Kapoor Madan

Psychiatry

Anxiety is the result of a hyperarousal state of nervous system due to a low threshold for threat perception. In simpler words, it's an ongoing flight or fight response. It can elicit a neuro-hormonal response understood as Flight or Fright reaction kicking in physiological cascade of symptoms ranging from palpitations, tachycardia, breathlessness, increased bowel movement, increase frequency of urination, dizziness, muscle tension or pain, trembling, dizziness, blurring of vision to restlessness, confusion and fainting spells. Chronic stress causes prolonged anxiety response with the consequences of slowed me ration, lack of concentration, headaches, fluctuations in blood pressure and increased wear and tear of body tissues. Identifying your stressors, learning to deal with them, de stressing regularly by doing something that makes one feel good, yoga and meditation are some non pharmacological strategies to deal with it. If the condition is persisting for a long time, it's better to see a psychiatrist.

What is the best ayurvedic medicine for lethargy,dullness,obsessive compulsive disorder, bipolar mood disorder,general anxiety disorder,gas,bloating,low digestive strength,low body energy,low concentration,too much attachment and paranoid behavior?

Dr. Deepak Kumar Soni

Ayurveda

https://www.1mgayush.com/otc/jiva-ashwagandha-tablet-otc3299671-1 Tablet after lunch & dinner, Take at least 1-2 months.

Mixed anxiety depressive disorder

Dr. Jyoti Kapoor Madan

Psychiatry

Saffron (Kesar)

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References

Bonate PL, Kroboth PD, Smith RB, et al. Clonazepam and sertraline: absence of drug interaction in a multiple-dose study. J Clin Psychopharmacol. 2000 Feb;20(1):19-27. [Accessed 31 Jan. 2026]. Available from: