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Zoderm E Cream

Oxiconazole (1% w/w)
Genuine
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Zoderm E Cream is an antifungal medicine used to treat fungal infections of the skin. It works by killing the fungus that causes infections such as athlete’s foot, Dhobie Itch, thrush, ringworm, and dry, flaky skin.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 07 Jan 2026 | 03:33 PM (IST)
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Gurgaon
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Product introduction

Zoderm E Cream should be used in the dose and duration as prescribed by your doctor. This medicine should be used regularly to get the most benefit from it. Do not use more than you need – it will not clear your condition faster and may only increase the side effects. Skin infections will usually get better after 2 to 4 weeks. Do not use the cream for longer than your doctor has told you to and let him or her know if your condition does not improve after 2 to 4 weeks of treatment. You can help the cream work better by keeping the affected areas clean, making sure they are dry and washing your hands before and after treating the infection. If you have athlete’s foot, wash your socks or tights thoroughly and change your shoes daily if possible.

The most common side effects of using this cream include a burning sensation and irritation, dryness, peeling or blistering of the skin. These are not usually serious, but you should call your doctor if you think you might have a severe allergic reaction. Signs of this include rash, swelling of the lips, throat or face, swallowing or breathing problems, feeling dizzy or faint and nausea. Get emergency help if this happens. Avoid direct contact of the cream or ointment with your eyes. In case of direct contact, wash your eyes with water and seek immediate medical attention.

it is not likely that other medicines you take by mouth or injection will affect the way this medicine works, but talk to your doctor before using it if you have recently used another cream that contains a steroid or had an allergic reaction to another antifungal medicine. This cream should only be used if it is clearly needed if you are pregnant or breastfeeding. Ask your doctor if it is safe.

Uses of Zoderm E Cream

Benefits of Zoderm E Cream

Fungal skin infections
Zoderm E Cream is an antifungal medicine. It kills and prevents the growth of fungus. This relieves the symptoms caused by the infection. It may be used to treat infections such as athlete’s foot, Dhobie Itch, thrush, ringworm, and dry, flaky skin. You should keep using it for as long as it is prescribed even if your symptoms have gone. This will prevent the infection from coming back. Using this medicine as prescribed will relieve pain and itching and may help you feel more comfortable with your skin.

Side effects of Zoderm E Cream

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Zoderm E
  • Skin irritation
  • Skin peeling
  • Blisters on skin
  • Dry skin
  • Burning sensation

How to use Zoderm E Cream

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.

How Zoderm E Cream works

Zoderm E Cream is an antifungal medication. It kills and stops the growth of the fungi by destroying its cell membrane, thereby treating your skin infection.

Quick tips

  • Zoderm E Cream helps treat skin infections caused by many different types of fungi.
  • Some tips for personal hygiene:
    • Wash your hands with soap before and after applying the cream.
    • Do not share your towel or clothes with anyone. 
    • Wear clean clothes every day to prevent infection. 
  • Finish the full course of treatment even if you feel better.
  • It can take a few weeks for the infection to clear and a few months before the skin returns to its normal color.
  • It is not taken orally, so it does not cause many side effects.
  • Apply an amount sufficient to cover the affected area and 1 inch of the immediate surrounding skin.
  • Avoid getting it in the eyes, nose, or mouth. If accidental exposure occurs, rinse immediately with plenty of water.
  • Inform your doctor if the infection has not cleared up after four weeks of treatment.

Safety advice

Alcohol

Alcohol

No interaction found/established
Pregnancy

Pregnancy

SAFE IF PRESCRIBED
Zoderm E Cream is generally considered safe to use during pregnancy. Animal studies do not indicate harmful effects. However, there are limited human studies.
Breast feeding

Breast feeding

CAUTION
Zoderm E Cream should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
The baby's skin should not come into direct contact with the treated area of skin. Water-miscible cream/gel is preferred as ointments may expose the baby to harmful effects of Zoderm E Cream via licking.
Driving

Driving

No interaction found/established
Kidney

Kidney

No interaction found/established
Liver

Liver

No interaction found/established

Frequently asked questions

The duration of the treatment depends on the type of infection. In general, the treatment is continued for 1 month for tinea infection and at least 15 days for candida infection. Do not stop the treatment on your own even if you feel better because the infection may come back as it takes some time to kill the fungus completely.
Always thoroughly wash your hands before and after applying Zoderm E Cream. If the feet are infected, they should be washed and dried thoroughly, especially between the toes, before applying Zoderm E Cream. It should be applied to form a thin and uniform layer onto the affected areas daily and should be rubbed in gently.
Zoderm E Cream is safe for use in children provided it is used in the recommended doses for the recommended period of time. Minor side effects may occur but usually they do not become bothersome. However, if you develop a burning sensation or areas of severe redness, itching, then stop the medicine and contact your doctor.
Keep the affected skin areas clean and dry and avoid excessive rubbing. The itchiness may give you an urge to scratch but avoid scratching as it will damage the surface of skin, spreading the infection further. Do not share towels, bath mats, etc. with other people as you could spread the infection to them.
Yes, Zoderm E Cream can cause side effects but not everyone gets affected by them. You may suffer from mild and transient rash or burning sensations that generally disappear rapidly.
Keep this medication in the container it came in, tightly closed, and out of the reach of children. The medication should be stored at room temperature (20°C to 25°C) and away from light, excess heat, and moisture (not in the bathroom).
No, do not stop using Zoderm E Cream without consulting your doctor even if you are feeling better. Your symptoms may improve before the infection is completely cured. Therefore, for better and complete treatment, it is advised to continue your treatment for the prescribed duration.

Fact Box

Chemical Class

Dichlorobenzenes

Habit Forming

No

Therapeutic Class

DERMA

Action Class

Fungal Ergosterol Synthesis Inhibitor

References

  1. Bennett JE. Antifungal Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. p. 1588.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1038.
  3. Oxiconazole. Pittsburgh, Pennsylvania: GlaxoSmithKline; 2004. [Accessed 29 Mar. 2019] (online) Available from:
  4. Central Drugs Standard Control Organisation (CDSCO). [Accessed 29 Mar. 2019] (online) Available from:
  5. CiplaMed. Oxiconazole Nitrate [Prescribing Information]. [Accessed 28 Mar. 2023] (online) Available from:
  6. Oxiconazole Nitrate. Mumbai, Maharashtra. GlaxoSmithKline Pharmaceuticals Ltd.; 2024 [Accessed 11Nov. 2025] (online). Available from:
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User feedback

Once A Day
60%
Twice A Day
40%
Others
100%
Average
39%
Excellent
32%
Poor
29%
No Side Effect
71%
Application site reactions (burning, irritation, itching and redness)
29%
With or without food
60%
With food
25%
Empty stomach
15%
Expensive
39%
Average
38%
Not Expensive
24%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Glaxo SmithKline Pharmaceuticals Ltd
Address: Dr. Annie Besant Road, Mumbai - 400 030

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Zoderm E Cream. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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