Zita Plus-Pio Tablet is a medicine used to treat type 2 diabetes mellitus in adults. It helps control blood sugar levels in people with diabetes. This helps prevent serious complications of diabetes like kidney damage and blindness.

Zita Plus-Pio Tablet may be used by itself or along with other medicines. It may be taken with or without food. Take it regularly at the same time each day to get the most benefit. Your doctor will decide what dose is best for you, and this may change from time to time according to how it is working.

Keep taking this medicine, even if you feel well or your blood sugar levels are controlled. If you stop it without consulting your doctor, your blood sugar levels could rise and put you at risk of kidney damage, blindness, nerve problems, and loss of limbs. Remember that it is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction as advised by your doctor. Your lifestyle plays a big part in controlling diabetes.

The most common side effects of taking this medicine include nasopharyngitis, upper respiratory tract infection, back pain, glucose in urine, ketones in urine, and blood in urine. Consult your doctor if these bother you or persist for a longer duration.

You should not take it if you have type 1 diabetes mellitus, if you have diabetic ketoacidosis (high levels of acid in your blood), or if you have severe kidney or liver disease. Before taking this medicine, tell your doctor if you have ever had heart disease, thyroid disease, or some hormonal conditions. It may not be suitable. Pregnant or breastfeeding women should also consult their doctor before taking it. Your blood sugar levels should be checked regularly, and your doctor may also advise blood tests to monitor your blood cell counts and liver function.

Uses of Zita Plus-Pio Tablet

Treatment of Type 2 diabetes mellitus

Benefits of Zita Plus-Pio Tablet

In Treatment of Type 2 diabetes mellitus

Zita Plus-Pio Tablet improves the body’s response to the hormone insulin, which is responsible for regulating blood glucose (sugar) levels in the body. The insulin helps lower your blood glucose levels and prevents them from rising after taking meals. You should keep taking it for as long as it is prescribed.

Lowering blood glucose levels is an essential part of managing diabetes. If you can control the level, you will reduce the risk of getting any of the serious complications of diabetes, such as kidney damage, eye damage, nerve problems, and loss of limbs. Taking this medicine regularly, along with proper diet and exercise, will help you live a normal, healthy life.

Side effects of Zita Plus-Pio Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Zita Plus-Pio

Nasopharyngitis (inflammation of the throat and nasal passages)
Upper respiratory tract infection
Back pain
Glucose in urine
Ketones in urine
Blood in urine

How to use Zita Plus-Pio Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zita Plus-Pio Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Zita Plus-Pio Tablet works

Zita Plus-Pio Tablet is a combination of two antidiabetic medications. Teneligliptin increases the release of insulin from the pancreas and decreases the hormone (glucagon) that raises blood sugar levels. This reduces the fasting and post-meal sugar levels. Pioglitazone works by increasing the body's sensitivity to insulin.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Zita Plus-Pio Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Information regarding the use of Zita Plus-Pio Tablet during pregnancy is not available. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Zita Plus-Pio Tablet during breastfeeding is not available. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether Zita Plus-Pio Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Kidney

CONSULT YOUR DOCTOR

There is limited information available on the use of Zita Plus-Pio Tablet in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited information available on the use of Zita Plus-Pio Tablet in patients with liver disease. Please consult your doctor.

What if you forget to take Zita Plus-Pio Tablet?

If you miss a dose of Zita Plus-Pio Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Zita Plus-Pio Tablet

₹12.6/Tablet

Tendia-P Tablet

Eris Lifesciences Ltd

₹12/tablet

5% cheaper

Zita-Pio Tablet

Glenmark Pharmaceuticals Ltd

₹13.8/tablet

10% costlier

Tenepride P 20mg/15mg Tablet

Micro Labs Ltd

₹10.7/tablet

15% cheaper

Tencrine P Tablet

Endocrine Pharma Pvt Ltd

₹11.5/tablet

9% cheaper

Joten P 20mg/15mg Tablet

Jarun Pharmaceuticals

₹14.4/tablet

14% costlier

Quick tips

Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol, or when delaying/skipping a meal. Check your blood sugar levels and have a snack/sugar source for immediate relief.
Be careful while driving or operating machinery until you know how this medicine affects you.
It is important for you to take care of the skin on your lower limbs and to report any sores or signs of infection to your doctor.
Inform your doctor if you experience fatigue, muscle weakness, or muscle pain.
Lifestyle changes like no sugar, exercise, not smoking, and cutting down on the amount of alcohol you normally drink may help this medicine work better.

Fact Box

Habit Forming

Therapeutic Class

ANTI DIABETIC

Patient concerns

I am taking glimpride 1/500 and Zita plus 20mg for 1 year .can I quit Zita plus

Dr. Sanjay Bhatt

Physician

Depends on your HbA1c control

Diabetes mellitus type 2 ,thirst

Dr. Sanjay Bhatt

Physician

A person can control his or her sugar levels by doing regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOUR DOCTOR AND FOLLOW ALL WHAT DOCTOR SUGGESTED.IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you should not treat it as disease but a start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications like kidney or heart problems .online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET

Zita Met 50-500 is not available can I take Zita met plus 20-500 instead of this Please send prescription for this

Dr. Sanjay Bhatt

Physician

I want prescription for buying medicine for tablets(zita plus 20mg)(glycomet

Dr. Sanjay Bhatt

Physician

It is easy to maintain sugar levels.You should have dedication to do regular exercise and maintain your calories intake which your diabetic educator have be told.As only medicine can't help for long time.secondly you you take proper dose of medicine which doctor has adjusted for you as per your reports.thirdly time visit to doctor and do all routine investigations.

What should you not eat while taking Zita Plus-Pio Tablet?

It is advisable to avoid foods that are high in saturated and trans fats; instead, consume fats from fish and nuts. Control your carbohydrate intake, as this directly affects your blood sugar.

Is Zita Plus-Pio Tablet safe to use?

Yes, Zita Plus-Pio Tablet is safe when used as directed by the doctor. However, it may show some side effects. For best results, it should be used in the correct dose and at the same time each day.

Can I stop taking Zita Plus-Pio Tablet if I feel better?

No, do not stop taking Zita Plus-Pio Tablet without talking to your doctor first. Sudden discontinuation of this medicine may worsen your diabetes. Inform your doctor if the symptoms bother you or if no considerable improvement is seen in your condition. The doctor may suggest some other medicine that could be more effective in treating your diabetes.

Can people with diabetes have proteins?

Yes, people with diabetes must include proteins along with other essential nutrients in their daily diet. Proteins are one of the major energy providers among all essential nutrients. Besides being the building blocks of the human body, proteins break down into glucose to release energy. Unlike carbohydrates, the metabolism of proteins into glucose is much slower. Therefore, the release of energy usually takes a few hours after consumption. Thus, the spike in blood sugar levels might occur after a few hours when you are on a high-protein diet. It is often recommended to consume about 2-3 servings of protein-rich snacks in the evening to avert the chances of hypoglycemia.

Are artificial sweeteners good for people with diabetes?

No, artificial sweeteners are not good for people with diabetes. They are composed of chemicals that can cause mild to severe side effects. Thus, it is better to limit or avoid their use as much as you can.

Can diabetes cause kidney failure?

Yes, uncontrolled diabetes can cause kidney failure. In the long run, diabetes can affect the kidneys, leading to a condition called diabetic nephropathy. This condition is a major cause of kidney failure in patients with diabetes. The best way to prevent damage to the kidneys is by keeping diabetes in check, making dietary changes, monitoring sugar levels regularly, getting routine blood tests done, and taking prescribed medications on time.

Can diabetes be cured?

No. Diabetes cannot be cured, but can be managed or controlled effectively. Diabetes is a condition that causes changes in your blood glucose levels, which, if left uncontrolled, can lead to serious health complications affecting the heart, brain, kidneys, and eyes. However, with simple lifestyle changes, diet, and medications, one can manage their condition and lead a healthy life.

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Related lab tests

Glucose - Fasting Blood

Glucose - Postprandial Blood

Glycosylated Hemoglobin

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Kadowaki T, Kondo K. Efficacy and safety of teneligliptin in combination with pioglitazone in Japanese patients with type 2 diabetes mellitus. J Diabetes Investig. 2013;4(6):576-84. [Accessed 25th Nov. 2022] (online) Available from:
Ethiopian Food and Drug Authority. Tenglyn (Teneligliptin 20mg) Film-coated Tablets [Internet]. 2023 Dec [cited 2025 Mar 4]. Available from:
Rwanda Food and Drugs Authority. TILYPTIN 20 (Teneligliptin) Tablet – Summary of Product Characteristics [Internet]. 2022 Nov [cited 2025 Mar 4]. Available from:
U.S. National Library of Medicine. Dapagliflozin Tablet – DailyMed Drug Label [Internet]. [cited 2025 Mar 4]. Available from:

Marketer details

Name: Glenmark Pharmaceuticals Ltd

Address: Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.