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Zerodol-MR Tablet is a combination medicine used in the treatment of pain due to muscle spasms. It improves the movement of muscles and provides relief from pain and discomfort associated with muscle spasms.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 09 Apr 2026 | 04:40 PM (IST)
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General Information

Contains

Aceclofenac (100mg)+ Tizanidine (2mg)

Marketer

Ipca Laboratories Ltd

Storage

Store below 25°C
The content is shown in English
Zerodol-MR Tablet image
Zerodol-MR Tablet image
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Zerodol-MR Tablet image
Zerodol-MR Tablet image

Product introduction

Zerodol-MR Tablet should be taken with food. This will prevent you from getting an upset stomach. You should take it regularly as advised by your doctor. Do not take more or use it for a longer duration than recommended by your doctor.

Some of the common side effects of this medicine include nausea, vomiting, stomach pain, heartburn, diarrhea, and loss of appetite. If any of these side effects bother you or do not go away with time, you should let your doctor know. Your doctor may help with ways to reduce or prevent these side effects.

The medicine may not be suitable for everybody. Before taking it, let your doctor know if you have any problems with your heart, kidneys, and liver. To make sure it is safe for you, let your doctor also know all the other medicines you are taking. Pregnant and breastfeeding mothers should first consult their doctors before using the medicine.

Uses of Zerodol-MR Tablet

  • Treatment of Pain due to muscle spasm

Benefits of Zerodol-MR Tablet

Treatment of Pain due to muscle spasm
Zerodol-MR Tablet is a combination medicine that contains a painkiller as well as a muscle relaxant. It is used to relieve pain, inflammation, and swelling in conditions that affect muscles. Also, it effectively relieves muscle stiffness or spasm, thereby improving muscle movement. It works by blocking chemical messengers in the brain that tell us we have pain.

Take it as prescribed by the doctor to get the most benefit. Do not take more or for a longer duration than needed as that can be dangerous. In general, you should take the lowest dose that works, for the shortest possible time. This will help you to go about your daily activities more easily and have a better, more active, quality of life.

Side effects of Zerodol-MR Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Zerodol-MR
  • Nausea
  • Sleepiness
  • Vomiting
  • Heartburn
  • Diarrhea
  • Loss of appetite
  • Dryness in mouth

How to use Zerodol-MR Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zerodol-MR Tablet should be taken with or after food.

How Zerodol-MR Tablet works

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) which works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). Tizanidine is a muscle relaxant. It works on the centers in the brain and spinal cord to relieve muscle stiffness or spasm and to improve pain and movement of muscles.

All substitutes for Zerodol-MR Tablet

For information purposes only. Consult a doctor before taking any medicine.

Asozen TZ Tablet

by Zeelab Pharmacy Pvt Ltd
₹2/tablet
83% cheaper
<h3 class=bodySemiBold>Asozen TZ Tablet</h3>

Azin-AC Tablet

by INTAS PHARMACEUTICALS LTD.
₹13.8/tablet
17% costlier
<h3 class=bodySemiBold>Azin-AC Tablet</h3>

Quick tips

  • Zerodol-MR Tablet helps relieve pain and muscle spasm that may occur due to strains, sprains, and muscle injuries.
  • It is usually used along with rest and physical therapy.
  • Take it with food to avoid an upset stomach.
  • It may cause dizziness. Do not drive or do anything requiring concentration until you know how it affects you.
  • Avoid consuming alcohol when taking Zerodol-MR Tablet as it may cause excessive drowsiness.

Safety advice

Alcohol

Alcohol

CAUTION
Alcohol should be used with caution while taking Zerodol-MR Tablet.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Zerodol-MR Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CAUTION
Zerodol-MR Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

UNSAFE
Zerodol-MR Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Zerodol-MR Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Zerodol-MR Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
Use of Zerodol-MR Tablet is not advised in patients with severe liver disease. Liver function tests are recommended before the start of treatment and then on a regular basis as advised.

Frequently asked questions

Zerodol-MR Tablet is a combination of two medicines: Aceclofenac and Tizanidine. This medication helps in relieving muscle pain. Tizanidine is a muscle relaxant which works by acting on the central nervous system. Aceclofenac works by lowering the chemical substance (prostaglandins) in the body that causes pain and inflammation.
Yes, Zerodol-MR Tablet is safe for most of the patients. However, in some patients it may cause some common side effects like nausea, vomiting, stomach pain / epigastric pain, heartburn, diarrhea, loss of appetite, dryness in the mouth, sleepiness and other uncommon and rare side effects. Inform your doctor if you experience any persistent problem while taking this medication.
Zerodol-MR Tablet is usually used for short term and can be discontinued when your pain is relieved. However, Zerodol-MR Tablet should be continued if your physician has advised you to do so.
Yes, the use of Zerodol-MR Tablet can cause nausea and vomiting. Taking it with milk, food or with antacids can prevent nausea. In case of vomiting, drink plenty of water or other fluids by taking small frequent sips. Also, avoid taking fatty or fried foods along with this medicine. Talk to your doctor if vomiting persists and if you notice signs of dehydration, like less urination with dark colored and strong-smelling urine. Do not take any other medicine without speaking to your doctor.
Yes, the use of Zerodol-MR Tablet can cause dizziness (feeling faint, weak, unsteady or lightheaded) in some patients. If you feel dizzy or lightheaded, it is better to rest for some time and resume once you feel better. Do not drive or use any machines.
The use of Zerodol-MR Tablet is considered to be harmful for patients with known allergy to any of the components or excipients of this medicine or in patients with known allergy to other painkillers (NSAIDs). The use of this medicine should preferably be avoided in patients with a history of stomach ulcers or in patients with active, recurrent stomach ulcer/bleeding. It should also be avoided in patients with a history of heart failure, high blood pressure, and liver or kidney disease.
No, taking a higher than the recommended dose of Zerodol-MR Tablet can increase the risks of side effects. If you are experiencing increased severity of pain or the pain is not relieved by the recommended doses, please consult your doctor for re-evaluation.
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Fact Box

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

References

  1. Tizanidine hydrochloride. Ardsley, New York: Acorda Therapeutics Inc; 1996 [revised 2013]. [Accessed 02 Apr. 20191] (online) Available from:
  2. DailyMed. Aceclofenac. [Accessed 23 Apr. 2019] (online) Available from:
  3. Pareek A, Chandurkar N, Chandanwale AS, et al. Aceclofenac-tizanidine in the treatment of acute low back pain: a double-blind, double-dummy, randomized, multicentric, comparative study against aceclofenac alone. Eur Spine J. 2009 Dec;18(12):1836-42. [Accessed 16 Sep. 2024] (online) Available from:
  4. Tizanidine hydrochloride [Prescribing Information]. Ardsley, NY: Acorda Therapeutics Inc.; 2013. [Accessed 16 Sep. 2024] (online) Available from:
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User feedback

Once A Day
60%
Twice A Day
40%
Muscle relaxation
43%
Others
40%
Dental pain
6%
Headache
6%
Fever
3%
Average
44%
Excellent
34%
Poor
23%
No Side Effect
78%
Heartburn
4%
Nausea
4%
Vomiting
3%
Stomach pain/epigastric pain
3%
With food
97%
With or without food
1%
Empty stomach
1%
Average
42%
Expensive
33%
Not Expensive
25%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Ipca Laboratories Ltd
Address: 142 AB, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Zerodol-MR Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's â„ž and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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