Yondelis Injection is used in the treatment of some kinds of cancers. It is used in patients with advanced soft tissue sarcoma when previous medicines have been unsuccessful. It is also used with other medicines as part of combination therapy to treat ovarian cancer that has come back.
Yondelis Injection is given as an injection under the medical supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include headache, fatigue, vomiting, weakness and increased liver enzyme. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver and kidney. Generally, avoid alcohol consumption while on treatment.
Before taking it, tell your doctor if have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using.This medicine is not recommended during pregnancy or while breastfeeding. Use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Soft tissue sarcoma is a rare type of cancer that begins in the body's connective tissues, such as muscles, fat, blood vessels, or nerves. It can occur anywhere in the body and may not show symptoms until it grows or spreads, making it harder to treat in later stages. Yondelis Injection is used when the disease does not respond well to standard chemotherapy. It works by interfering with the DNA inside cancer cells, helping slow down or stop their growth. This can help reduce tumor size, delay disease progression, and relieve symptoms like pain or swelling, ultimately improving the patient's daily functioning and quality of life.
Side effects of Yondelis Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Yondelis
Headache
Fatigue
Vomiting
Weakness
Nausea
Increased liver enzymes
Low blood platelets
Increased creatine phosphokinase (CPK) level in blood
Decreased white blood cell count (neutrophils)
Decreased appetite
Constipation
How to use Yondelis Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Yondelis Injection works
Yondelis Injection belongs to class of drugs called alkylating agents. It works by sticking to the DNA in cells and damaging it. This stops the cancer cells growing and multiplying.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Yondelis Injection.
Pregnancy
CONSULT YOUR DOCTOR
Information regarding the use of Yondelis Injection during pregnancy is not available. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Yondelis Injection during breastfeeding is not available. Please consult your doctor.
Driving
UNSAFE
Yondelis Injection may cause side effects which could affect your ability to drive. Yondelis Injection may make you feel tired and experience a loss of strength which may affect your ability to drive.
Kidney
CAUTION
Yondelis Injection should be used with caution in patients with kidney disease. Dose adjustment of Yondelis Injection may be needed. Please consult your doctor.
Liver
CAUTION
Yondelis Injection should be used with caution in patients with liver disease. Dose adjustment of Yondelis Injection may be needed. Please consult your doctor.
What if you forget to take Yondelis Injection?
If you miss a dose of Yondelis Injection, please consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
Yondelis Injection is given as an intravenous infusion (IV infusion) under the supervisión of a doctor.
Do not skip any dose and complete the course as suggested by your doctor.
Use an effective method of birth control to avoid pregnancy while taking this medication.
Inform your doctor if you notice yellowing of eyes or skin, dark urine, muscle pain and skin rash.
Your doctor may get regular blood tests done to monitor your blood cell count, platelet count and liver function.
Fact Box
Chemical Class
Benzazocine Derivative
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Other Anticancer Agents
Interaction with drugs
Taking Yondelis with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
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I have 2 lumps in my right wrist which do not hurt me or cause pain but they can be moved little bit closer to where it is formed. Need to get rid of it.
Dr. Atula Gupta
Dermatology
Surgical excision after X Ray wrist and USG soft tissue
I have been suffering from heavy cold, sneezing and blocked nose for 5 months. Getting cured once I take some medicine temporarily. Always feels like something blocked in throat like mucous.
Dr. Saurav Arora
Homeopathy
Please get Xray soft tissue neck, xray PNS, AEC, IgE and Hemogram
My nose is blocked with mucus many times a day especially when I woke up in morning. My ears are also not able to listen fully. When I do some ear exercise of filling the mouth with air and swallowing the saliva, my ears open up. But the problem is persisting from many years.
Dr. Saurav Arora
Homeopathy
Please get xray PNS and soft tissue neck, Hemogram, AEC and IgE levels
I fell down while playing five weeks ago. The doctors told me there is no fracture but a soft tissue injury.I have not recovered completely still.How many more days will it take? Will i be able to walk and run normally like before?
Dr. Deepak Kumar Soni
Ayurveda
It will take some time soft tissue injuries take more time to recover .
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References
Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1719-20.
Trabectedin. Hertford, Herts: Immedica; 2007 [revised Jun. 2018]. [Accesed 27 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:
Marketer details
Name: Janssen Pharmaceuticals
Address: Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060