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Velpaclear Tablet is a combination of two antiviral medicines. This prescription medicine is used in the treatment of chronic hepatitis C virus (HCV) infection. It fights against the viruses to resolve the infection.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 17 Dec 2025 | 04:35 PM (IST)
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General Information

The content is shown in English
Velpaclear Tablet image
Velpaclear Tablet image

Product introduction

Velpaclear Tablet should be taken in the prescribed dose and duration. It can be taken with or without food, but take it at the same time daily. It is advised not to consume more than the recommended dose. It is important to inform your doctor if you have any health conditions such as liver or kidney disease. It is harmful to consume alcohol along with this medicine, so it is advised to limit or avoid alcohol. The course of the medicine should be completed for better results.

The common side effects of this medicine include fatigue, anemia, nausea, headache, insomnia, and diarrhea. You should drink plenty of fluid and eat a healthy diet to prevent or overcome the side effects. Before taking the medicine, inform your doctor if you are taking any other medicines or supplements.

Uses of Velpaclear Tablet

  • Treatment of Chronic hepatitis C virus (HCV) infection

Benefits of Velpaclear Tablet

Treatment of Chronic hepatitis C virus (HCV) infection
Hepatitis C is a liver infection caused by the hepatitis C virus (HCV). When the infection moves into a long-lasting stage, it is called chronic hepatitis C virus infection. Velpaclear Tablet helps reduce the number of hepatitis C virus by preventing it from spreading in your body. This helps control the infection and helps you recover faster. It is important that you take this medicine as prescribed, following the dosage recommended by your doctor.

Side effects of Velpaclear Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Velpaclear
  • Headache
  • Diarrhea
  • Insomnia (difficulty in sleeping)
  • Anemia (low number of red blood cells)
  • Nausea
  • Fatigue

How to use Velpaclear Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Velpaclear Tablet may be taken with or without food.

How Velpaclear Tablet works

Velpaclear Tablet is a combination of two antiviral medicines: Sofosbuvir and Velpatasvir. They work by lowering the amount of hepatitis C virus in the body and removing the virus from the blood over a period of time.

Quick tips

  • Velpaclear Tablet is used for the treatment of chronic hepatitis C virus (HCV) infection.
  • Take it with food, preferably at the same time everyday.
  • You will usually need to take this medicine every day for either 12 or 24 weeks.
  • Skipping doses increases the risk of treatment failure. Make sure that you take all your doses at the correct time.
  • It may cause fatigue, dizziness, and blurred vision. Don't drive or do anything requiring concentration until you know how it affects you.
  • Velpaclear Tablet may cause headaches. Drink plenty of water and take a suitable painkiller. Inform your doctor if it does not go away.
  • Your doctor may monitor your liver function and the amount of hepatitis C virus in your body regularly. 
  • Do not stop taking this medicine without your doctor’s advice.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Velpaclear Tablet. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Information regarding the use of Velpaclear Tablet during pregnancy is not available. Please consult your doctor.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Velpaclear Tablet may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Driving

Driving

UNSAFE
Velpaclear Tablet may cause side effects that could affect your ability to drive.
Velpaclear Tablet, when taken together with other medicines for the treatment of hepatitis c infection, may produce dizziness, blurred vision and this may affect your ability to drive.
Kidney

Kidney

CAUTION
Velpaclear Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Limited information is available on the use of Velpaclear Tablet in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.
Liver

Liver

SAFE IF PRESCRIBED
Velpaclear Tablet is safe to use in patients with liver disease. No dose adjustment is recommended.
However, inform your doctor if you have any kidney disease as regular monitoring of liver function tests may be advised in some patients while taking this medicine.

Frequently asked questions

Velpaclear Tablet is used to treat chronic hepatitis C infection in adults and children 3 years and older. It works across all six main types of hepatitis C virus, is often combined with another medicine in difficult-to-treat cases.
When taken as directed by your doctor, Velpaclear Tablet is highly effective, with most patients achieving a sustained virologic response. This meaning the virus is not detectable in the blood twelve weeks after completing treatment.
People should not take Velpaclear Tablet if they are allergic to sofosbuvir, velpatasvir, or any ingredient in the medicine, are taking certain other medicines that strongly interact, such as rifampicin, or St. John’s wort.
Yes. Though rare, Velpaclear Tablet can cause serious allergic reactions. Seek immediate medical help if you develop rash, swelling of the face or throat, trouble breathing, or severe dizziness.
Yes. If you have had hepatitis B in the past, Velpaclear Tablet may cause the virus to become active again. Your doctor will test you for hepatitis B before starting Velpaclear Tablet treatment, monitor you closely if needed.
Serious side effects of Velpaclear Tablet include slow or irregular heartbeat, extreme tiredness, confusion, jaundice (yellowing skin or eyes), severe weakness, or unusual bleeding. Seek immediate medical attention if you experience any of these symptoms.
Yes, Velpaclear Tablet is commonly used in patients with liver disease, including compensated cirrhosis (an early, often asymptomatic stage of cirrhosis where the liver is significantly scarred but still functioning well enough for the body to compensate for the damage). However, if you have decompensated cirrhosis, your doctor may prescribe Velpaclear Tablet with other medicine, monitor you more closely.
Yes. When Velpaclear Tablet is taken with another medicine called amiodarone, it can cause dangerous slowing of the heart rate. Patients on amiodarone need close monitoring, especially at the start of treatment.

Fact Box

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User feedback

Chronic hepatitis C virus (HCV) infection
100%
Excellent
44%
Poor
33%
Average
22%
No Side Effect
67%
Headache
33%
With or without food
67%
With food
33%
Expensive
100%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Abbott
Address: 16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Velpaclear Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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