Medicine Overview of Validay 50mg/10mg Tablet
Diclofenac is used for pain relief
It relieves pain in conditions like headache, mild migraine, muscle pain, dental pain, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, or painful menses.
Abdominal pain, Constipation, Diarrhoea, Epigastric pain, Flatulence, Nausea, Vomiting, Indigestion.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID). It works by suppressing the production of chemical messengers (prostaglandins) that cause inflammation (redness and swelling), fever and pain.
Nausea, Headache, Abdominal pain, Constipation, Flatulence, Diarrhoea.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.
Rabeprazole is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in relief of acid-related indigestion and heartburn.
In Depth Information on Validay 50mg/10mg Tablet
It should be taken with food or milk to avoid getting an upset stomach.
- It can cause serious complications like stomach bleeding and kidney problems if taken for a long time.
Diclofenac can raise a risk of blood clots, heart attack, or a stroke.
- Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
- Inform your doctor if you have ever been diagnosed with kidney or liver problems.
- Inform your doctor if you do not feel better after taking it for 14 days as you may be suffering from some other problem that needs attention.
- Rabeprazole can decrease magnesium levels in blood. Get your magnesium levels checked regularly. You may need a magnesium supplement or need to discontinue your medicine.
- Inform your doctor if you are suffering from osteoporosis as Rabeprazole can weaken your bones by decreasing calcium levels in blood. You may need a calcium supplement, preferably calcium citrate.
- Rabeprazole is a well-tolerated medicine and provides relief for a long time.
- It may take a few days to show its effect. You can take an antacid for a quick relief during this time unless your doctor has asked you not to use them.
- Once you start feeling better, do not stop taking your medicine. Take it for the duration as advised by your doctor
Validay Tablet related warnings
Taking a large amount of alcohol can increase acidity and cause acid reflux in the food pipe causing heartburn. This would decrease the effect of this drug and can aggravate your underlying condition.
WEIGH RISKS VS BENEFITS
Validay 50mg/10mg Tablet is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Validay 50mg/10mg Tablet is probably unsafe to use during lactation.
Limited human data suggest that the drug could represent a significant risk to the baby.
Do not drive unless you are feeling well.
Validay 50mg/10mg Tablet may cause headaches, blurred vision, dizziness or drowsiness in some patients. This may affect your ability to drive.
Validay 50mg/10mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Validay 50mg/10mg Tablet may be needed. Please consult your doctor.
Validay 50mg/10mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Validay 50mg/10mg Tablet may be needed. Please consult your doctor.
Regular monitoring of liver function tests is recommended in patients with liver disease if this medicine is to be taken for a long time.
Frequently asked questions about Validay 50mg/10mg Tablet
Q. Can Diclofenac be used along with warfarin?
No. Using Diclofenac together with warfarin can increase the risk of serious bleeding from the stomach (Higher than users of either drug alone). Inform your doctor before starting these medications.
Q. Is Diclofenac a painkiller?
Yes. Diclofenac is a pain killer. In fact, it belongs to the class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). It is commonly used for the treatment of pain in osteoarthritis, rheumatoid arthritis and spondylitis.
Q. Is Diclofenac a narcotic?
No, Diclofenac is not a narcotic. Narcotics are drugs with sleep inducing properties, usual derivatives of Opium like Heroin and Morphine.
Q. Can I use Diclofenac along with vitamins?
Yes, Diclofenac can be taken with vitamins. No drug-drug interactions or any harmful effects have been reported when they are used together.
Q. Can Diclofenac be used for the treatment of hepatitis?
No, Diclofenac is not approved for the treatment of hepatitis. Hepatitis is a condition where the liver is inflamed. Diclofenac can, in fact, cause harm to the liver as a side effect.
Q. Can Diclofenac be used after C-section?
Yes, Diclofenac is a pain killer. C-section is the short name for Cesarean Section which is an operative procedure to deliver the baby through the mother's abdomen and uterus. Diclofenac can be used to treat the pain that may occur after the operation.
Q. Can I take Diclofenac along with misoprostol?
Yes. It can be taken together. Misoprostol protects the stomach from irritating gastric effects of Diclofenac. The combination of medication is used to treat arthritis in patients at high risk of getting stomach/intestinal ulcers and complications from the ulcers (such as bleeding).
Q. Can I take Diclofenac while I am on thyroxine?
Yes, Diclofenac can be taken with thyroxine. No drug-drug interactions or any harmful effects have been reported when they are used together.
Q. Why Diclofenac should be stopped before surgery?
Since Diclofenac has been shown to have blood thinning effects, it can increase the risk of bleeding. Therefore, it is stopped before surgery to prevent excessive loss of blood.
Q. What are the contraindications for Diclofenac?
Diclofenac should not be used if there is an allergic reaction (hypersensitivity) to it, or other pain killers, active ulcer in the stomach, bleeding from the stomach, history of severe heart failure, liver failure, kidney failure and or heart attack.
Q. Can Diclofenac affect the chance of conceiving?
Yes. Diclofenac can sometime cause reversible infertility. Diclofenac by its mechanism of action, may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consult your doctor before starting this medication.
Q. Why does Diclofenac cause an ulcer?
Diclofenac can cause damage to the lining cells of the stomach by several mechanisms, including the irritant effect on the cells, breaking of the protective barrier properties of lining cells, suppression of prostaglandin production of the stomach, reduction of stomach mucosal blood flow and interference with the repair of superficial injury of the stomach lining.
Q. Why is Diclofenac contraindicated in asthma?
Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory drugs (NSAID) like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.
Q. Is Diclofenac good for back pain?
Yes, Diclofenac has been found to be effective to reduce back pain. Diclofenac is a pain killer that belongs to the NSAIDs (Non-Steroidal Anti-Inflammatory) class. Other NSAIDs have also been found to be useful in back pain eg. Ibuprofen and Naproxen.
Q. Can I use Diclofenac during my fever treatment?
Yes, Diclofenac can reduce fever. However, commonly used to reduce the pain, particularly that which is seen with Osteoarthritis, Rheumatoid Arthritis and Ankylosing spondylitis.
Q. Can I use Diclofenac to treat a sore throat?
Sore throat is mostly caused by bacteria so antibiotics are given to treat a sore throat whereas Diclofenac is a pain killer so it can be given in cases of throat pain associated with it but only under the prescription of a doctor.
Q. Can I use Diclofenac to treat urinary tract infections (UTI)?
Diclofenac can be used to treat the pain associated with urinary tract infection (UTI) but for complete treatment, a course of antibiotics will be required.
Q. Can Diclofenac cause sedation?
Diclofenac is not known to cause sedation. There have been rare, an isolated case report of sedation with the drug.
Q. Can I take Diclofenac for kidney stones?
Yes,Diclofenac can be used to relieve the pain due to kidney stones. However, there is also a risk of kidney damage with Diclofenac as its side effect. It is advised not to take Diclofenac for a prolonged time for this condition without adequate monitoring.
Q. Can I use Diclofenac for the treatment of arthritis?
Yes, Diclofenac is commonly used for the treatment of pain in osteoarthritis, rheumatoid arthritis, and spondylitis.It belongs to the class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). .
Q. Can I use Diclofenac with diuretics?
No, Diclofenac should not be used with diuretics. Diclofenac reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.
Q. Can I use Diclofenac with mifepristone?
These drugs should not be used together as the effect of mifepristone may be lowered by Diclofenac. Mifepristone is used for medical abortion.
Q. Can I use Diclofenac with lithium?
No.These drugs should not be used together as Diclofenac increases the blood levels of lithium which may further increase the side effects.
Q. Is Rabeprazole an over the counter product?
No, Rabeprazole is not an over the counter product, it is available when prescribed by a doctor.
Q. Is Rabeprazole an antacid?
Rabeprazole is not an antacid. It belongs to the class of proton pump inhibitors (PPIs) which decrease the amount of acid produced in the stomach while antacids only neutralize the stomach acid by coating the stomach.
Q. Does Rabeprazole cause osteoporosis (thinning of bones)?
Yes, long term use of Rabeprazole can cause osteoporosis (thinning of bones). It decreases the calcium absorption leading to calcium deficiency and increases the risk of bone fractures of hip, wrist or spine. Inform your doctor if you have osteoporosis or if you are taking corticosteroids (these can increase the risk of osteoporosis) before starting your therapy. Take enough calcium and vitamin D to reduce the risk.
Q. Can I take aluminum hydroxide and magnesium carbonate or other antacids with Rabeprazole?
Rabeprazole can be taken with antacids like aluminum hydroxide, magnesium carbonate or sodium bicarbonate. Rabeprazole takes a few days to show its effect, so antacids can be taken during that time for relief of acidity and heartburn. However, antacids should be taken two hours before or one hour after taking Rabeprazole as antacids can increase the pH of the stomach and decrease the action of Rabeprazole which requires a lower pH for its action.
Q. Does Rabeprazole have addictive potential?
No, Rabeprazole has no addictive potential. It shows no withdrawal symptoms when you stop using this medicine.
Yes, Rabeprazole is safe if taken for prescribed duration in prescribed doses as advised by your doctor. However, there are some very common side effects that you can experience at effective doses like nausea, abdominal pain, constipation, diarrhea, and flatulence.
Q. Does Rabeprazole cause hair loss?
No, hair loss has not been reported as a side effect of Rabeprazole. Talk to your doctor in case there is excessive hair fall as it could be due to some underlying problem that needs attention.
Q. Does Rabeprazole cause flatulence (gas or bloating)?
Flatulence (gas) has been reported as a common side effect of Rabeprazole. Although it would be mild to moderate in nature and transient.
Q. Does Rabeprazole cause tinnitus (ringing in the ears)?
Tinnitus (ringing sensation in the ears) has not been seen as a side effect with the use of Rabeprazole. Talk to your doctor in case you have this problem as it could be due to some underlying condition that needs attention.
Q. Does Rabeprazole cause weight gain?
Weight gain has been reported as a rare side effect of Rabeprazole. Weight gain can add to your problem of acidity and heartburn. So, you must try to do some exercise and make healthy changes in your diet to control your weight.
Q. Does Rabeprazole expire?
Yes, like any other medicine, Rabeprazole also expires. Always check the expiry date on the pack of the medicine before using it.
Q. Does Rabeprazole cause constipation?
Constipation is a common side effect seen in patients using Rabeprazole. Making healthy lifestyle changes like doing yoga, taking high fiber diet and plenty of fluids will prevent constipation.
Q. Does Rabeprazole cause high blood pressure?
Rabeprazole is not reported to cause high blood pressure. In case you experience high blood pressure, talk to your doctor as it may need attention. Common side effects seen with Rabeprazole includes nausea, abdominal pain, constipation, diarrhea, and flatulence.
Q. Does Rabeprazole cause headache?
Headache is reported as one of the common side effects of Rabeprazole. Please consult your doctor in case you experience an intolerable headache for a prolonged duration while taking Rabeprazole.
Q. Can I take Rabeprazole with ranitidine?
Yes, Rabeprazole can be taken with ranitidine. As Rabeprazole show its effect after some days, Ranitidine can be taken for immediate relief. No drug-drug interactions or change in side effect profile has been reported when they are used together compared to either drug alone.
Q. Can I take Rabeprazole with ibuprofen?
Rabeprazole can be taken with ibuprofen. Rabeprazole is used to prevent painkiller (NSAIDs) induced gastritis and stomach ulcers by decreasing the production of acid in the stomach. There are no reported drug interactions or harmful effects when they are used together.
Q. Can I take Rabeprazole with paracetamol?
Rabeprazole can be taken with paracetamol. Rabeprazole is used to prevent painkiller (NSAIDs) induced stomach ulcers by decreasing the production of acid in the stomach. There are no reported drug interactions or harmful effects when they are used together.
Q. How is Rabeprazole metabolized?
Rabeprazole is metabolized in the liver mainly by microsomal CYP450 enzymes (CYP2C19 and CYP3A4). Patients with poor CYP2C19 enzymatic activity will have higher levels of Rabeprazole for a long time and a better suppression of stomach acid.
Q. Can Rabeprazole be used for the treatment of throat infection?
No, Rabeprazole is not meant for throat infections. However, it may be given along with antibiotics and other drugs to protect the stomach from excessive acid secretion.
Q. Why is Rabeprazole used with cinitapride for some conditions?
Cinitapride increases the movement of the gut and is useful in the treatment of conditions like heartburn, dyspepsia and is also useful in the treatment of reflux esophagitis. It has much better efficacy when it is used with Rabeprazole.
Q. Does Rabeprazole play any role in treating ulcerative colitis?
Rabeprazole does not have any role in the treatment of ulcerative colitis. However, it can be given if there is associated dyspepsia or increased stomach acid secretion. Talk to your doctor before taking any treatment for ulcerative colitis.
Q. Can Rabeprazole be used for reflux esophagitis?
Yes, Rabeprazole is effective in the treatment of reflux esophagitis. It is a disease in which stomach acid or bile irritates and inflames the lining of the food pipe. Rabeprazole decreases the production of acid in the stomach and can help in healing the inflamed and eroded esophagus.The efficacy is better when it is given in combination with a prokinetic agent like domperidone.
Q. Is Rabeprazole being used for treating weight loss?
No, Rabeprazole is not used for the treatment of weight loss. It is a proton pump inhibitor and is used for the treatment of acidity, heartburn, intestinal ulcers and stomach ulcers.
Q. Is there any role of Rabeprazole in treating hiatus hernia?
A hiatus hernia is the bulging of the stomach into the chest through an esophageal opening in the diaphragm which is larger than the normal size. A hiatus hernia is associated with acidity and heartburn. Rabeprazole does not play any role in treating hiatus hernia, however, it can help in relieving the symptoms of acidity, heartburn and acid reflux.
Q. Can I take Rabeprazole with vitamin D?
Yes, vitamin D can be taken with Rabeprazole. Vitamin D is generally advised to be taken as a supplement with Rabeprazole as its long-term use decreases the absorption of calcium and cause calcium deficiency. This can lead to osteoporosis (thinning of bones) and increase the risk of bone fractures like hip, wrist and spine fractures.
Q. How is Rabeprazole useful in the treatment of H. pylori?
Rabeprazole is used along with antibiotics for the treatment of H.Pylori infection. It works by decreasing stomach acid volume and decreasing breakdown and washout of antibiotics leading to an increased antibiotic concentration and tissue penetration. It also helps in the symptomatic relief by decreasing associated acidity, reflux, and heartburn.
Q. Can I take Rabeprazole with domperidone?
Rabeprazole can be safely taken with domperidone as no harmful effects have been reported clinically. A fixed-dose combination of these two medicines is also available. Domperidone increases gut motility and Rabeprazole decreases the acid production in the stomach. So, this combination is very effective in the treatment of reflux esophagitis associated with acidity, heartburn, intestinal and stomach ulcers.
Q. Can long term use of Rabeprazole cause magnesium deficiency?
Long-term use of Rabeprazole can lower magnesium levels in patients taking multiple daily doses for a year or longer (at least 3 months). Get your magnesium levels checked at regular intervals. Tell your doctor if you experience seizures, dizziness, abnormal or fast heartbeat, jitteriness, jerking movements or shaking (tremors), muscle weakness, spasms of the hands and feet, cramps, muscle aches or spasm of the voice box.
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