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MRP: Rs. 38 for 1 strip(s) (10 tablets each)
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food interaction for TUSSNIL

alcohol interaction for TUSSNIL

pregnancy interaction for TUSSNIL

lactation interaction for TUSSNIL

Avoid Tussnil tablet with caffeine and chocolate as well as food containing caffeine and chocolate such as tea leaves, cocoa beans.
Tussnil tablet may cause excessive drowsiness and calmness with alcohol.
Taking phenylpropanolamine with alcohol can increase the risk of cardiovascular side effects such as increased heart rate, chest pain, or blood pressure changes.
Tussnil tablet may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Phenylpropanolamine(25 mg)


Phenylpropanolamine is used to relieve blocked nose or sinuses caused by common cold and seasonal nasal allergies (hay fever). It is also used to decrease appetite for weight control.

How it works

Phenylpropanolamine belongs to a class of medications called nasal decongestants. It stimulates receptors on blood vessels in the nose and sinuses leading to its constriction and reduction in blood flow thereby relieving congestion.

Common side effects

Nausea, Palpitations, Psychosis, Chest tightness, Dizziness, Epileptic convulsion, Hallucination, Headache, Increased blood pressure, Tremor
Chlorpheniramine(2 mg)


Chlorpheniramine is used to relieve symptoms of  runny nose, sneezing, itching, and watery eyes caused by allergies, the common cold, or the flu and allergies due to food and insect bites and hay fever.

How it works

Chlorpheniramine belongs to class of medications called antihistamines. It acts by blocking a natural chemical (histamine) that your body makes during an allergic reaction. Histamine is responsible for many symptoms of allergy. 

Common side effects

Nausea, Constipation, Drowsiness, Dry mouth, Dry throat, Dry skin, Headache, Inability to empty the urinary bladder, Loss of appetite, Nasal congestion, Chest congestion, Vomiting
Guaifenesin(100 mg)


Guaifenesin is used to relieve cough and chest congestion.

How it works

Guaifenesin belongs to a class of agents called expectorants. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways.

Common side effects

Nausea, Itchy rash, Hypersensitivity reaction, Stomach pain, Diarrhoea, Vomiting
Paracetamol(500 mg)


Paracetamol is used for the relief of mild to moderate pain in conditions such as headache (including migraine), toothache, ear pain, joint pain, pain during menstruation, fever, feverish colds, and flu.

How it works

Paracetamol belongs to class of medications called analgesics (painkiller) and antipyretics (fever reducing). Paracetamol reduces pain by increasing the pain threshold. It reduces fever by acting on the temperature-regulating region of brain, resulting in increased blood flow across the skin, sweating and heat loss.

Common side effects

Skin redness, Allergic reaction, Shortness of breath, Running nose, Nausea, Liver injury, Abnormal blood cell count, Facial swelling, Blisters on skin
Bromhexine(8 mg)


Bromhexine is used to treat breathing difficulties caused by excessive mucus secretions in the air passages associated with respiratory tract infections.

How it works

Bromhexine belongs to the class of medications called as expectorants/mucolytic agents. It acts by thinning the mucus which facilitates expectoration and eases cough.

Common side effects

Irritation of ear, Allergic skin rash, Dizziness, Headache


No substitutes found

Expert advice for TUSSNIL

  • Do not continue phenylpropanolamine for more than 7 days if your condition does not improve or if you have high fever.
  • Tell your doctor if you have high blood pressure, heart problems, liver or kidney disease, diabetes, prostate enlargement or visual problems due to increased pressure in the eyes (glaucoma).
  • Seek immediate medical attention and discontinue medication if you experience difficulty in breathing, sudden swelling or skin reactions, fits, rapid heartbeat or hallucinations.
  • Use with caution if you are a woman or an elderly patient. Woman may be at a higher risk of haemorrhagic stroke (bleeding in the brain).
  • Avoid driving or operating machinery if you feel dizzy or drowsy after taking phenylpropanolamine.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.
  • Do not take if allergic to phenylpropanolamine or any of its ingredients.

Frequently asked questions for TUSSNIL


Q. Is phenylpropanolamine a controlled substance?
Phenylpropanolamine is a controlled substance since it can be used for manufacturing of illegal drugs.

Q. Is phenylpropanolamine the same as phenylephrine?
Phenylpropanolamine and phenylephrine are different drugs belonging to the same class of medications (nasal decongestants). Both are used to relieve blocked nose or sinuses caused by common cold and seasonal nasal allergies (hay fever).

Q. Is phenylpropanolamine still on the market?
Phenylpropanolamine is banned in India due to increased risk of haemorrhagic stroke (bleeding in the brain) and is no longer marketed in India.

Q. Does phenylpropanolamine cause stroke?
Phenylpropanolamine has shown to increase the risk of hemorrhagic stroke (bleeding in the brain). Women are at a higher risk.


Q. Does chlorpheniramine or chlorpheniramine maleate cause increase in blood pressure/ drowsy/non drowsy/sedating/get you high/keep you awake/sleepiness/make you tired/weight gain?
Chlorpheniramine causing these side effects is common or rare. Always consult your doctor, if you experience any of these side effects.
Q. Is chlorpheniramine like Benadryl?
No, chlorpheniramine is different from Benadryl.
Q. Is chlorpheniramine prescription?
Yes, it is available with doctor’s prescription only.
Q.Can I take chlorpheniramine or chlorpheniramine maleate with Panadol/ cetirizine /Zyrtec/ Allegra/ warfarin/ diphenhydramine/ ibuprofen/Claritin/guaifenesin/Benadryl?
Yes, but taking other medicines may alter the effects of chlorpheniramine. Always consult your doctor for the change of dose regimen or an alternative drug of choice that may strictly be required.
Q. Does chlorpheniramine contain aspirin?
No, it does not contain aspirin in it. Chlorpheniramine is a different drug than aspirin.


Q. What is Guaifenesin used for?
Guaifenesin is an expectorant, mainly used to relieve chest congestion by aiding the removal of mucus.
Q. What is Ascoril+/Ascoril LS/ Ascorl D cough syrup?
Ascoril+ cough syrup contains terbutaline, while Ascorl LS contails levosalbutamol. In addition both syrups contain bromhexine and guaifenesin and are used to relieve cough due to acute and chronic inflammation of the airways (bronchitis) and other cough conditions.
Ascoril D is a medicine for dry cough and it does not contain guaifenesin.
Q. Is Ascoril+ an antibiotic?
No, Ascoril+ cough syrup contains terbutaline, bromhexine and guaifenesin. It does not contain any antibiotic.
Q. Does Ascoril+/ Ascoril LS cause drowsiness?
No, terbutaline, levosalbutamol, bromhexine and guaifenesin do not cause any drowsiness. Hence, Ascoril+ or Ascoril LS syrup does not cause drowsiness.
Q. How long can I take guaifenesin?
Consult your doctor for use more than 7 days.
Q. Can I take guaifenesin if I have high blood pressure?
Guaifenesin should not be taken by individuals with high blood pressure 
Q. Can I take guaifenesin with phenylephrine, ibuprofen, amoxicillin and paracetamol (acetaminophen)?
There are no known drug interactions between phenylephrine, ibuprofen, amoxicillin and paracetamol (acetaminophen) and guaifenesin. However, consult your doctor about all medications currently taken before starting and while on guaifenesin.
Q. Can I take guaifenesin with Sudafed (pseudoephedrine-decongestant preparation) and Dayquil (OTC cold and cough preparation), Benadryl, benzonatate?
Guaifenesin can be taken with other cold and cough preparation including Sudafed, Dayquil, Benadryl and benzonatate . However, other formulations containing guaifenesin must be avoided to avoid a double dose. Also, guaifenesin should not be combined with cough suppressants in the treatment of cough since the combination would not be logical and you may be exposed to unnecessary side effects. 


Q. Is paracetamol safe/ banned/ available in India?
Paracetamol (also known as acetaminophen, crocin, dolo, calpol, pacimol) is an over-the-counter drug available in India. It is generally safe if used at prescribed doses for the prescribed duration as advised by your doctor.
Q. Is paracetamol a painkiller/ used for cold?
Paracetamol is used to relieve mild to moderate pain associated with cold and flu, as well as fever.
Q. Does paracetamol make you drowsy / sleepy? 
Paracetamol does not cause drowsiness. However, paracetamol is available in combination with cough and cold medicines (eg. cetirizine, chlorpheniramine), which may cause drowsiness or sleepiness.
Q. Is paracetamol an NSAID/ antibiotic?
Paracetamol is a anti-pyretic (anti-fever), anti -inflammatory drug, which belongs to the category of non-steroidal anti-inflammatory drug (NSAID). However, unlike other NSAIDS, paracetamol can relieve only mild to moderate pain.
It is not an antibiotic.
Q. Can I take crocin with cetirizine/ aceclofenac/ amoxicillin/ codeine/ tramadol/ warfarin/ erythromycin/ antibiotics?
Yes, paracetamol (available as crocin) can be taken with all of these drugs. Caution is advised when crocin is to be used with warfarin. However, always consult your doctor regarding combined use of crocin with any other drug.
Q. Can I take crocin with ibuprofen/naproxen/other NSAID?
Paracetamol (available as crocin) is available over-the-counter in combination with ibuprofen/naproxen/other NSAID. However, always consult your doctor regarding combined use of crocin with any other drug.
Q. Does paracetamol cause death?
Paracetamol on overdose can severely damage the liver and cause death. No more than 4 grams should be consumed in one day. Always consult your doctor regarding use of paracetamol.
Q. Can calpol make babies/ toddlers sleep/ help in teething pain?
Calpol can relieve pain in infants and children; it does not make them sleep.


Q. Is Bromhexine an antihistamine?
No, Bromhexineis not an antihistamine.


Content on this page was last updated on 15 February, 2014, by Dr. Varun Gupta (MD Pharmacology)