Trypentin Gel

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 29 Dec 2025 | 01:14 PM (IST)

Trypentin Gel is used for the treatment of neuropathic pain. It works by cooling the skin then warming it up. This cooling and warming up action blocks the pain signal transmission through nerves to reach the brain and decreases the pain sensation.

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₹190 MRP ₹206.258% off

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General Information

Contains

Gabapentin (6% w/w)+ Lidocaine (5% w/w)

Marketer

Polaire Pharmaceuticals

Storage

Store below 30°C

The content is shown in English

Product introduction

Trypentin Gel is for external use only. You should use it in the dose and duration as advised by your doctor. You must wash your hands thoroughly before and after applying this medicine. This medicine should be used regularly to get the most benefit from it. Do not stop using it until you have finished the complete course, even when you feel better.

The most common side effects of this medicine include application site reactions like burning, irritation, itching, and redness. These are usually mild but let your doctor know if they bother you or last more than a few days. Avoid direct contact with eyes, nose, or mouth. If accidental exposure occurs, rinse immediately with plenty of water. Before using this medicine inform your doctor if you are pregnant.

Uses of Trypentin Gel

Neuropathic pain

Benefits of Trypentin Gel

Neuropathic pain
Trypentin Gel is a combination of medicines used to treat long-lasting (chronic) pain caused by nerve damage due to diabetes, shingles or spinal cord injury. It reduces pain and its associated symptoms such as mood changes, sleep problems, and tiredness. Gabapentin, an active ingredient of this medicine, is thought to work by interfering with pain signals that travel through the damaged nerves and the brain.

Side effects of Trypentin Gel

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Trypentin

Application site reactions (burning, irritation, itching and redness)

How to use Trypentin Gel

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Wash your hands after applying, unless hands are the affected area.

How Trypentin Gel works

Trypentin Gel is a combination of two medicines: Gabapentin and Lidocaine. Gabapentin is an alpha 2 delta ligand which decreases pain by modulating calcium channel activity of the nerve cells. Lidocaine is a local anesthetic which works by blocking pain signals from the nerves to brain thereby decreasing the sensation of pain. Together, they relieve neuropathic pain (pain from damaged nerves).

All substitutes for Trypentin Gel

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Trypentin Gel is used to treat certain types of long-lasting pain caused by damage to nerves.
Avoid contact with the eyes, mouth, nose and rinse thoroughly in case of accidental contact or seek medical help in case of swallowing.
Inform your doctor if you are taking any other pain-relieving medicines.
Along with taking Trypentin Gel, your doctor might advise you to undergo physiotherapy to get relief from pain.

Safety advice

Alcohol

No interaction found/established

Pregnancy

CONSULT YOUR DOCTOR

The safety of Trypentin Gel during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

SAFE IF PRESCRIBED

Trypentin Gel may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Driving

No interaction found/established

Kidney

No interaction found/established

Liver

No interaction found/established

Frequently asked questions

What is Trypentin Gel used for?

Trypentin Gel is used to help manage neuropathic pain. It works by cooling the skin, then warming it up. This cooling and warming action may help interrupt pain signal transmission through nerves to the brain and reduce pain sensation.

What serious allergic reactions could Trypentin Gel cause?

Rare but severe allergic reactions to Trypentin Gel may include rash, swelling, redness, persistent itching, difficulty breathing, or numbness spreading away from the area. Seek urgent medical help if these occur.

Can Trypentin Gel be used by children or older adults?

Trypentin Gel is typically meant for adults aged 18 years and older. For older adults, start with a small quantity to minimize any increased sensitivity or risk.

What symptoms mean I should stop using Trypentin Gel and see a doctor?

Unexplained severe rash, swelling, burning, persistent skin ulcers, or trouble breathing after using Trypentin Gel require immediate medical attention.

Are there risks if Trypentin Gel is used for too long or on a large skin area?

Long-term or high-quantity use of Trypentin Gel on large body areas may increase the risk of toxicity or severe reactions. Follow your doctor’s advice on dosage and application areas.

Should I avoid covering the Trypentin Gel-treated area with a bandage?

Unless your doctor advises otherwise, avoid wrapping or bandaging the area after Trypentin Gel application, as this may increase absorption and side effects.

What are the warning signs of nerve damage from using Trypentin Gel?

If you experience severe numbness, tingling far from the treated area, or weakness, stop using Trypentin Gel and contact your doctor.

Should I share Trypentin Gel with others who have similar pain?

Fact Box

Habit Forming

Therapeutic Class

NEURO CNS

References

Finnerup NB, Attal N, Haroutounian S, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015 Feb;14(2):162-73. [Accessed 29 Dec. 2025]. Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Polaire Pharmaceuticals
Address: Andhra Pradesh, Hyderabad / C-9, Maa Karni Nagar-C, Near Gandhipath, Vaishali Nagar, Jaipur-302021

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Trypentin Gel

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Trypentin Gel

Benefits of Trypentin Gel

Side effects of Trypentin Gel

How to use Trypentin Gel

How Trypentin Gel works

All substitutes for Trypentin Gel

Sentidor Gel

Lidogab Gel

Adgaba Gel

Gapitas-L Gel

Gabapax L Gel

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Trypentin Gel used for?

What serious allergic reactions could Trypentin Gel cause?

Can Trypentin Gel be used by children or older adults?

What symptoms mean I should stop using Trypentin Gel and see a doctor?

Are there risks if Trypentin Gel is used for too long or on a large skin area?

Should I avoid covering the Trypentin Gel-treated area with a bandage?

What are the warning signs of nerve damage from using Trypentin Gel?

Should I share Trypentin Gel with others who have similar pain?

Fact Box

Habit Forming

Therapeutic Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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