Topimac 20 Tablet

Topiroxostat (20mg)

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Topimac 20 Tablet is a medicine used to treat and prevent gout. It lowers the levels of uric acid by stopping its release from the kidneys.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 13 Mar 2026 | 01:39 PM (IST)

₹86.5 MRP ₹93.758% off

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Topimac 20 Tablet is currently sold out

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Topiroxo 20mg Tablet

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Available alternative from Alkem Laboratories

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Topimac 20 Tablet

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Same composition

Topiroxo 20mg Tablet

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Topiroxostat (20mg)

by Alkem Laboratories Ltd

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General Information

Contains

Topiroxostat (20mg)

Marketer

Macleods Pharmaceuticals Pvt Ltd

The content is shown in English

Product introduction

Topimac 20 Tablet should be taken with food. This will prevent you from getting an upset stomach. Take it regularly and do not stop taking the medicine even if you get better until that doctor tells you it is alright to stop.

Use of this medicine may cause increased liver enzymes in some people. If you experience any other side effects which do not go away with time or bothers you, you should let your doctor know. Your doctor may help with ways to reduce or prevent these symptoms by prescribing you an alternative medicine or by adjusting the dose.

To make sure the medicine is safe for you, let your doctor know if you have any problems with your heart, kidneys, or liver. You should also let your doctor know all the other medicines you are taking before using this medicine. If you are pregnant or breastfeeding, consult your doctor first before taking this medicine.

Uses of Topimac Tablet

Gout

Benefits of Topimac Tablet

Gout
Topimac 20 Tablet is used to prevent and treat gout. Gout is caused by too much uric acid in your body. When the level becomes too high, crystals may form in and around certain joints and your kidneys. This can cause sudden and severe pain, redness, warmth, and swelling. This medicine works by reducing the levels of uric acid in your blood. This makes it less likely that you will suffer the symptoms and make them milder if you do have them. It is usually for long-term treatment and should be taken regularly until the dose is completed.

Side effects of Topimac Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Topimac

Increased liver enzymes

How to use Topimac Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Topimac 20 Tablet may be taken with or without food.

How Topimac Tablet works

Gout occurs due to increased blood uric acid levels. Topimac 20 Tablet reduces the synthesis of uric acid by inhibiting the enzyme involved in it.

All substitutes for Topimac 20 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Topiroxo 20mg Tablet

by Alkem Laboratories Ltd

₹10.5/tablet

21% costlier

Toxur 20mg Tablet

by Blisson Mediplus Pvt Ltd

₹9.52/tablet

10% costlier

Quick tips

Take adequate water or fluids while taking Topimac 20 Tablet to prevent kidney stones.
Treatment with this medicine should not be started during a sudden/severe gout attack. Wait until your current attack is over before starting this medication.
Consult your doctor before taking it if you have or ever had kidney stones, stomach ulcers, peptic ulcers, diabetes, liver disorders or blood disorders.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
Take adequate water or fluids while taking Topimac 20 Tablet to prevent kidney stones.
Treatment with this medicine should not be started during a sudden/severe gout attack. Wait until your current attack is over before starting this medication.
Consult your doctor before taking it if you have or ever had kidney stones, stomach ulcers, peptic ulcers, diabetes, liver disorders or blood disorders.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Topimac 20 Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Information regarding the use of Topimac 20 Tablet during pregnancy is not available. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Topimac 20 Tablet during breastfeeding is not available. Please consult your doctor.

Driving

UNSAFE

Topimac 20 Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Topimac 20 Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Topimac 20 Tablet in patients with liver disease.

Frequently asked questions

What is the dose of Topimac 20 Tablet?

The usual adult dosage of Topimac 20 Tablet is 20 mg/dose orally given twice daily in the morning and evening. Thereafter, the dosage should be gradually increased, as needed, while monitoring blood uric acid levels. The usual maintenance dosage should be 60 mg/dose twice daily. The dose may be adjusted based on the patient’s condition, up to 80 mg/dose twice daily.

Can a patient with kidney disease take Topimac 20 Tablet?

Patients with kidney disease should be given Topimac 20 Tablet with caution due to the higher risk of side effects in these patients.

What is the most important precaution to be kept in mind while taking Topimac 20 Tablet?

The dose of Topimac 20 Tablet should be increased gradually, i.e., starting dose should be 20 mg/dose twice daily, and the dose should be increased gradually, for example, to 40 mg/dose twice daily at or after Week 2, and then to 60 mg/dose twice daily at or after Week 6. The patient should be adequately monitored after the dose increase.

Fact Box

Chemical Class

Pyridyl- 1,2,4- triazoles

Habit Forming

Therapeutic Class

PAIN ANALGESICS

Action Class

Xanthine Oxidase Inhibitors

Related lab tests

Creatinine

Creatinine - Spot

Uric Acid

References

Chandrashekara S, Mahesh E. Topiroxostat-A Safer Uricostatic Drug with Enhanced Renal Protection: A Narrative Review. J Assoc Physicians India. 2024 Nov;72(11):73-79. [Accessed 05 Jan. 2026]. Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Macleods Pharmaceuticals Pvt Ltd
Address: Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Topimac 20 Tablet

Save more with additional offers

General Information

Contains

Marketer

Product introduction

Uses of Topimac Tablet

Benefits of Topimac Tablet

Side effects of Topimac Tablet

How to use Topimac Tablet

How Topimac Tablet works

All substitutes for Topimac 20 Tablet

Topiroxo 20mg Tablet

Toxur 20mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is the dose of Topimac 20 Tablet?

Can a patient with kidney disease take Topimac 20 Tablet?

What is the most important precaution to be kept in mind while taking Topimac 20 Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Creatinine

Creatinine - Spot

Uric Acid

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests