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Topcef Plus Tablet is a combination medicine. It is prescribed to treat various types of bacterial infections. It fights against the infection to prevent the growth and further spread of the microorganisms. It also prevents diarrhea which may occur as a side effect of this medicine.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 29 Apr 2026 | 11:11 AM (IST)
₹44.7 MRP ₹49.4110% off 
We do not facilitate sale of this product at present
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General Information

Contains

Cefixime (100mg)+ Dicloxacillin (NA)+ Lactobacillus (NA)

Marketer

Torrent Pharmaceuticals Ltd

Storage

Store below 30°C
The content is shown in English
Topcef Plus Tablet image
Topcef Plus Tablet image

Product introduction

Topcef Plus Tablet is a prescription medicine. It is advised to take it as per the prescription. It can be taken with or without food, but it must be taken at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine.

Some common side effects of this medicine are nausea, vomiting, diarrhea, indigestion, etc. If any of the side effects get aggravated, you must consult your doctor immediately. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.

Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Pregnant or breastfeeding women should also consult with their doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy.

Uses of Topcef Plus Tablet

Benefits of Topcef Plus Tablet

Treatment of Bacterial infections
Topcef Plus Tablet stops the growth of infectious bacteria and helps treat infections caused by bacteria. Topcef Plus Tablet also contains beneficial bacteria that protect the inner layers of your stomach and intestines. This medicine can relieve frequent loose motions, that may occur as a side effect of this medicine, and also prevents them from coming back. It usually makes you feel better within a few days, but you should continue taking it as prescribed even when you feel better to make sure that all bacteria are killed and do not become resistant. Drink plenty of fluids while taking it to make sure you stay hydrated.

Side effects of Topcef Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Topcef Plus
  • Nausea
  • Vomiting
  • Diarrhea
  • Stomach pain
  • Indigestion
  • Flatulence
  • Rash

How to use Topcef Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Topcef Plus Tablet may be taken with or without food.

How Topcef Plus Tablet works

Topcef Plus Tablet is a combination of three medicines: Cefixime, Dicloxacillin and Lactobacillus. Cefixime and Dicloxacillin are antibiotics which work by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria in the human body. Together, they treat your infection effectively. Lactobacillus is a live microorganism which restores the balance of good bacteria in the intestine that may get upset with antibiotic use or due to intestinal infections.

Quick tips

  • You have been prescribed this combination medicine to treat bacterial infections.
  • Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
  • Talk to your doctor if you notice bloody stools or develop abdominal cramps.
  • Take it with food and plenty of fluids to avoid an upset stomach.
  • Stop taking Topcef Plus Tablet and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Topcef Plus Tablet. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Topcef Plus Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CAUTION
Topcef Plus Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

UNSAFE
Topcef Plus Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Topcef Plus Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Topcef Plus Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

Yes, the use of Topcef Plus Tablet can cause nausea and vomiting. Taking it with milk, food or with antacids can prevent nausea. Avoid taking fatty or fried foods along with this medicine. In case of vomiting, drink plenty of water or other fluids by taking small frequent sips. Talk to your doctor if vomiting persists and you notice signs of dehydration, like dark colored and strong-smelling urine and a low frequency of urination. Do not take any other medicine without speaking to a doctor.
The use of Topcef Plus Tablet should be avoided in patients with known allergy to any of the components or excipients of this medicine.
No, do not stop taking Topcef Plus Tablet and complete the full course of treatment even if you feel better. Your symptoms may improve before the infection is completely cured.
Usually, Topcef Plus Tablet starts working soon after taking it. However, it may take some days to kill all the harmful bacteria and make you feel better.
Inform your doctor if you don't feel better after finishing the full course of treatment. Also, inform him if your symptoms are getting worse while using this medicine.
Yes, the use of Topcef Plus Tablet can cause diarrhea. It is an antibiotic which kills the harmful bacteria. However, it also affects the helpful bacteria in your stomach or intestine and causes diarrhea. If you are experiencing severe diarrhea, talk to your doctor about it.
Cefixime is a cephalosporin antibiotic which treats infection by killing the bacteria responsible for the infection. Dicloxacillin is an antibiotic in the penicillin group of drugs. It fights bacteria in your body and is used to treat many different types of infections caused by bacteria such as bronchitis, pneumonia, or staphylococcal (also called "staph") infections.
Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Yes, Topcef Plus Tablet is used for treating pharyngitis and tonsillitis. But please consult your doctor before taking the medicine.

Fact Box

Habit Forming

No

Therapeutic Class

ANTI INFECTIVES

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

  1. Brogden RN, Campoli-Richards DM. Cefixime. A review of its antibacterial activity. Pharmacokinetic properties and therapeutic potential. Drugs. 1989 Oct;38(4):524-50. [Accessed 10 Jan. 2026]. Available from:
  2. Kelesidis T, Pothoulakis C. Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders. Therap Adv Gastroenterol. 2012 Mar;5(2):111-25. [Accessed 10 Jan. 2026]. Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Torrent Pharmaceuticals Ltd
Address: Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India

Vendor Details

Country of origin: India

Lab tests offered by us

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