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Tilpazan Solution for Injection

Inclisiran (284mg)
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Tilpazan Solution for Injection is a medicine used alongside a healthy diet and statin therapy to help lower cholesterol levels in adults with heart disease. Cholesterol is a fatty substance that builds up in the blood vessels and causes narrowing. Lowering cholesterol levels reduces the risk of heart attack and stroke.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 23 Mar 2026 | 11:29 AM (IST)
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Tilpazan Solution for Injection image
Tilpazan Solution for Injection image

Product introduction

Tilpazan Solution for Injection is administered subcutaneously into the abdomen, upper arm, or thigh. Do not inject in areas of active skin disease or injury, such as sunburns, rashes, inflammation, or skin infections. A doctor or a nurse generally administers it, and it should not be self-administered at home.


It is important to have your cholesterol levels checked regularly. This medicine is only one part of a treatment program, which should also include a healthy diet, regular exercise, smoking cessation, moderation of alcohol intake, and weight reduction. You can eat normally while taking this medicine, but try to avoid foods high in fat.


Common side effects of this medicine include injection site reactions, joint pain, urinary tract infection, diarrhea, bronchitis, pain in extremities, and shortness of breath. Before taking it, let your doctor know if you are suffering from any liver or kidney disease. Pregnant and breastfeeding women should consult the doctor before taking this medicine.

Uses of Tilpazan Solution for Injection

Side effects of Tilpazan Solution for Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Tilpazan
  • Injection site reactions (pain, swelling, redness)
  • Joint pain
  • Urinary tract infection
  • Diarrhea
  • Bronchitis (inflammation of the airways)
  • Pain in extremities
  • Breathlessness

How to use Tilpazan Solution for Injection

Your doctor or nurse will guide you how to use this medicine.

How Tilpazan Solution for Injection works

Tilpazan Solution for Injection turns off, or ‘silences,’ the gene PCSK9, which boosts the liver’s ability to remove harmful cholesterol from the blood.

Quick tips

  • Avoid self-injection unless trained properly, as improper technique may affect absorption and effectiveness of Tilpazan Solution for Injection.
  • Do not shake the prefilled syringe or pen, as this may damage the medication and reduce its potency.
  • Report any persistent injection site reactions (pain, redness, swelling) to your doctor. These are usually mild but should not be ignored if prolonged.
  • Inform your doctor/nurse about any injection site reaction.
  • Inform your doctor about any active skin disease or injury, such as sunburns, skin rashes, inflammation, or skin infections.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Tilpazan Solution for Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Tilpazan Solution for Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Tilpazan Solution for Injection during breastfeeding is not available. Please consult your doctor.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Tilpazan Solution for Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

CAUTION
Tilpazan Solution for Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Tilpazan Solution for Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

Tilpazan Solution for Injection is a prescription cholesterol-lowering medication used in adults with high LDL cholesterol. It works by helping the liver remove more bad LDL cholesterol from the blood. Tilpazan Solution for Injection blocks a protein called PCSK9, which allows the liver to absorb and break down more LDL cholesterol and remove it from the blood.
Tilpazan Solution for Injection is given as a subcutaneous injection (under the skin) by a healthcare professional. You get one dose at the start, another at 3 months, and then one injection every 6 months, making it a biannual cholesterol treatment.
Yes, Tilpazan Solution for Injection is generally safe for people with mild to moderate kidney or liver disease. However, if you have severe kidney or liver issues, your doctor will monitor you more closely. No dose changes are usually needed.
If your next Tilpazan Solution for Injection due is less than 3 months late, take it as soon as possible and continue your usual schedule. If it is more than 3 months late, your doctor will restart your treatment schedule.
The serious side effects of Tilpazan Solution for Injection are rare, but you should not take Tilpazan Solution for Injection if you are allergic to any of its ingredients. If you have severe liver or kidney issues, your doctor will decide if it is right for you.
Tilpazan Solution for Injection begins working within 14 days, and the full cholesterol-lowering effect is usually seen within 30 to 60 days after injection. Its effects are long-lasting, with LDL cholesterol still reduced after 6 months.
Unlike daily oral medications, Tilpazan Solution for Injection requires only two to three injections per year, which may improve adherence for some patients. It works by targeting the production of PCSK9 in the liver. This way, the liver's ability to remove low-density lipoprotein cholesterol (LDL-C) from the blood is increased, offering an alternative mechanism for lowering LDL-C compared to other treatments.
Tilpazan Solution for Injection is intended for adults who have not reached their cholesterol goals with lifestyle changes and maximum tolerated statin medication therapy. It is not recommended for individuals with certain conditions or those who are pregnant or breastfeeding. Consult your doctor to determine if Tilpazan Solution for Injection is right for you.

Fact Box

Chemical Class

Small interfering rnas

Habit Forming

No

Therapeutic Class

CARDIAC
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100% genuine products
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Lupin Ltd
Address: 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India

Vendor Details

Country of origin: Switzerland
A licensed vendor partner from your nearest location will deliver Tilpazan Solution for Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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