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Composition for TIBROLIN

Bromelain(90 mg),Trypsin(48 mg),Rutoside(100 mg)

food interaction for TIBROLIN

alcohol interaction for TIBROLIN

pregnancy interaction for TIBROLIN

lactation interaction for TIBROLIN

There is no data available. Please consult doctor before consuming the drug.
Interaction with alcohol is unknown. Please consult your doctor.
Human and animal studies are not available. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Bromelain(90 mg)


Bromelain is used for reducing swelling (inflammation) after surgery or injury, especially of the nose and sinuses. It is also used for hay fever, treating a bowel condition that includes swelling and ulcers (ulcerative colitis), removing dead and damaged tissue after a burn (debridement), preventing the collection of water in the lung (pulmonary edema), relaxing muscles, stimulating muscle contractions, slowing clotting, improving the absorption of antibiotics, preventing cancer, shortening labor, and helping the body to get rid of fat.

How it works

Bromelain is an enzyme obtained from pineapple juice. It causes the body to produce substances that fight pain and swelling (inflammation). It also contains chemicals that interfere with the growth of tumor cells and slow blood clotting.

Common side effects

Vomiting, Nausea, Altered menstrual cycle, Diarrhoea, Abdominal pain, Shortness of breath, Tachycardia
Trypsin(48 mg)


Trypsin is used to treat osteoarthritis, ulcers, wound cleansing and healing and to improve digestion.

How it works

Trypsin is an enzyme, which breaks down proteins into smaller fragments, thereby making it available for absorption into the blood. Trypsin when applied directly to wounds and ulcers removes dead tissue and improves healing.

Common side effects

Rash, Chest tightness, Shortness of breath, Itching, Mouth swelling, Pain, Stinging sensation, Burning sensation, Urticaria
Rutoside(100 mg)


Hemorrhoids, surgical anaesthesia, zollinger-ellison syndrome.

How it works

Not known.

Common side effects

Restlessness, Nervousness, Pounding in the ears, Blurred vision, Dizziness, Headache, Itching, Limb swelling, Ankle swelling, Rash, Skin redness, Stomach upset, Tachycardia, Heart rate irregular, Heaviness, Weakness


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Expert advice for TIBROLIN

  • Do not start or continue the bromelain, If you are allergic to pineapple, latex, wheat, celery, papain, carrot, fennel, cypress pollen, or grass pollen, bromelain. 
  • Do not start or continue the bromelain, If you are pregnant or breast feeding.
  • Do not use bromelain at least 2 weeks before a scheduled surgery.

Frequently asked questions for TIBROLIN


Q. Is bromelain safe?
This drug is safe if used at prescribed dose and duration as advised by your doctor.
Q. Is bromelain gluten free/ in pineapple?
Yes. Drug is gluten free. However, please refer to package insert of the prescribed brand before use. Yes, pineapple contains some amount of bromelain in it.
Q. Is bromelain good for gout?
It is not indicated for gout, but may be used in treatment of joint pain. Patients should follow  the advice of the doctor regarding its use.
Q. Is bromelain safe to take before surgery?
No, it is not safe to take before surgery. Patients should follow the advice of the doctor  regarding its use.
Q. How long can I take bromelain for?
Patient should take bromelain for prescribed dose and duration as advised by your doctor.
Q. Can I take bromelain with antibiotics/ibuprofen/prednisone/Coumadin?
No, taking other medicines may alter the effects of bromelain. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Q. Does bromelain help with weight loss/swelling/inflammation?
Yes, it is used to reduce swelling, inflammation and helps with weight loss by getting rid of fat.
Q. Does bromelain work?
Yes, it works at prescribed dose and duration for particular disease condition as advised by your doctor.
Q. Does bromelain increase blood pressure/ thin the blood?
Bromelain causing these side effects is rare or uncommon. Always consult your doctor if you experience these side effects.
Q. Does bromelain aid digestion?
It may aid digestion by contraction of smooth muscles, but is used to treat swelling and ulcers (ulcerative colitis). Patients should follow the advice of the doctor regarding its use.


Q. Is trypsin an enzyme, hormone, protein, endopeptidase?
Trypsin is an enzyme, a protein, an endopeptidase. Trypsin is not a hormone.
Q. Is trypsin acidic or basic?
Trypsin is neither acidic nor basic, it works on optimal operating pH of about 7.5-8.5.
Q. Is trypsin a zymogen, lipase?
Trypsin is a zymogen prior to activation. Trypsin is not a lipase.
Q. Is trypsin found in the stomach?
Yes, trypsin is found in the stomach.

Q. Does trypsin work in the stomach?
Yes, trypsin  works in the stomach.
Q. Is trypsin harmful?
Trypsin is not harmful if used as recommended. 

Q. Does trypsin kill cells?
Trypsin can damage the cells. In case, of any side effects, consult your doctor. 
Q. Does trypsin digest itself?
Trypsin digests itself.

Q. Does trypsin digest proteins?
Trypsin digests/breaks down proteins into smaller fragments.

Q. Does trypsin break down starch or fats?
 Trypsin does not breaks down starch or fats. Trypsin can digest itself.
Q. Does trypsin activate pepsinogen?
Trypsin does not activate pepsinogen. 

Q. Does trypsin cleave histidine?
Trypsin does not cleave histidine.
Q. Does trypsin require calcium?
In presence of the calcium trypsin remains stabilized which possess greater enzyme activity.


Content on this page was last updated on 18 October, 2016, by Dr. Varun Gupta (MD Pharmacology)