Tepapro Injection is used in the treatment of cancers of the brain, breast, lungs, and ovaries. It is used in combination with other cancer medicine during hematopoietic progenitor cell transplantation (HPCT). It may be also used to treat other conditions, as determined by the doctor.

Tepapro Injection is generally given under the supervision of a healthcare professional. Your doctor will decide the dose and duration of the treatment based on the severity of your condition and what you are being treated for. It may take several weeks or months for you to see or feel the benefits but do not stop getting the injection unless your doctor tells you to.

The most common side effects of this medicine include decreased white blood count, anemia, low blood platelets, increased liver enzymes, increased bilirubin in the blood, mucosal inflammation, hemorrhage, diarrhea, blood in urine, and rash. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidneys, liver, and heart function during treatment with this medicine.

Before taking it, tell your doctor if you have bleeding, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Tepapro Injection

Benefits of Tepapro Injection

In Ovarian cancer

Ovarian cancer is a cancer that begins in the female organs that produce eggs (ovaries). This type of cancer is usually detected very late and can be fatal too. It usually spreads to the pelvis and stomach. Tepapro Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective medicine but has some side effects that may be bothersome. So, you should discuss the risks and benefits with your doctor.

In Non-small cell lung cancer

Non-small cell lung cancer is one of the major kinds of lung cancer and it affects both smokers as well as non-smokers. Tepapro Injection helps treat non-small cell lung cancer and may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

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Side effects of Tepapro Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Tepapro

Anemia (low number of red blood cells)
Low blood platelets
Decreased white blood cell count (neutrophils)
Increased liver enzymes
Increased bilirubin in the blood
Mucosal inflammation
Hemorrhage
Rash
Diarrhea
Blood in urine

How to use Tepapro Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Tepapro Injection works

Tepapro Injection is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Tepapro Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Tepapro Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

UNSAFE

Tepapro Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Tepapro Injection may cause side effects which could affect your ability to drive.
It is likely that certain adverse events of Tepapro Injection are dizziness, headache, and blurred vision which could affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Tepapro Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Tepapro Injection may not be needed in these patients. Please consult your doctor.

Liver

CAUTION

Tepapro Injection should be used with caution in patients with liver disease. Dose adjustment of Tepapro Injection may be needed. Please consult your doctor.
Regular monitoring of liver function tests may be advised while you are taking this medicine.

What if you forget to take Tepapro Injection?

If you miss a dose of Tepapro Injection, please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Tepapro Injection

₹10040/Injection

Therotepa 15mg Injection

Therdose Pharma Pvt Ltd

₹17718.75/injection

62% costlier

Tepakin 15mg Injection

MSN Laboratories

₹17250/injection

58% costlier

Quick tips

Tepapro Injection is given as an intravenous infusion (IV infusion) under the supervisión of a doctor.
Do not skip any dose and complete the course as suggested by your doctor.
Use an effective method of birth control to avoid pregnancy while taking this medication.
Your doctor may get regular blood tests done to monitor your blood cell count, platelet count and liver function.
It makes you feel dizzy. Do not drive or operate machinery until you know how it affects you.

Fact Box

Chemical Class

Thiophosphoric Acids Derivatives

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Alkylating Agents

Interaction with drugs

Taking Tepapro with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Lenograstim (Injection Route) Life-threatening

Do not consume Lenograstim from 24 hours before until 24 hours after undergoing cytotoxic chemotherapy. Concurrent use may cause a decrease in the ability of the bone marrow to pr... More

Molgramostim (Injection Route) Life-threatening

Do not consume Thiotepa from 1 day before until 1 day after taking Molgramostim. Please consult your doctor. Concurrent use may cause a decrease in the ability of the bone marrow ... More

Pegfilgrastim (Injection Route) Life-threatening

Do not consume Thiotepa from 14 days before until 24 days after taking Pegfilgrastim. Please consult your doctor. Concurrent use may cause a decrease in the ability of the bone ma... More

Sargramostim (Injection Route) Life-threatening

Do not consume Thiotepa from 1 day before until 1 day after taking Sargramostim. Please consult your doctor. Concurrent use may cause a decrease in the ability of the bone marrow ... More

Natalizumab (Injection Route) Life-threatening

Do not consume Natalizumab with Thiotepa. Concomitant use may increase the risk of opportunistic infections.

View all drug interactions

Patient concerns

What is the purpose of Chemotherepy given at the time of radiotherapy in ca lung small cell carcinoma

Dr. Vijay Sharnangat

Medical Oncology and Hematology

This is given to enhance the therapeutic effect of radiation therapy which is curative for small cell lung cancer.

My mother have ovarian cancer. I want to consult docter how much serious my mother according to reports When will i get my answer

Dr. Sanjay Singh Rai

Medical Oncology and Hematology

U have to do FNAC from tumorIf positive for cancer Chemotherapy will be done

My father in law is a lung cancer patient.He had gone through two chemo cycles.The first one led to a significant reduction of about 50% in the tumor size.He was administered gemcitabine and carboplatin.However,the 2nd one was ineffective.Please advise as to what could be the next course of action. He was a smoker and has non-small cell carcinoma.The cancer has spread to the adrenal glands.

Dr. Sanjay Singh Rai

Medical Oncology and Hematology

U have to do a CT SCAN 3WKS AFTER 3RD CHEMOBased on that u make assessment of response

I want to know the symptoms of cancer as I am a smoker

Dr. Vijay Sharnangat

Medical Oncology and Hematology

Symptoms for cancer depends upon which organ involved. For smokers , definitely chronic , they have possibility to develop lung cancer, head and neck cancers, oesophagus cancer, pancreatic cancer, stomach cancer and so more on. General symptoms would be like loss of appetite, weight loss, low grade fever in some cases, chronic cough for long time.

Related lab tests

Breast Cancer (CA 15.3/ ER/ PR)

Related ayurvedic ingredients

Olive oil

Green Tea

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1685.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1355-56.
Thiotepa. Lugano, Switzerland: ADIENNE SA; 1959 [revised Jan. 2017]. [Accessed 27 Mar. 2019] (online) Available from: