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Talecalm Plus Tablet is a combination medicine used in the treatment of schizophrenia (a mental disorder in which a person develops unreal thoughts and behavior). It alters the thoughts and elevates the mood, improving the person’s ability to think, feel and behave.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 06 Jan 2026 | 03:42 PM (IST)
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Talecalm Plus Tablet image
Talecalm Plus Tablet image
Talecalm Plus Tablet image
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Product introduction

Talecalm Plus Tablet also helps by improving muscle control and reducing the stiffness of the muscle. It may be taken with or without food, preferably at the same time each day. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember it. Do not skip any doses and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to your doctor as it may worsen your symptoms.

Some common side effects of this medicine include nausea, constipation, dryness in mouth, sedation, abnormal heart rhythm, urinary retention, blurred vision, and nervousness. Initially, this medicine may cause a sudden drop in blood pressure when you change positions, rise slowly if you have been sitting or lying down. It may also cause dizziness and sleepiness, do not drive or do anything that requires mental focus until you know how this medicine affects you.

Before taking it, inform your doctor if you are suffering from thyroid or kidney problems, epilepsy, Parkinson’s disease, glaucoma, or any heart problems. You should not take this medicine if you are under the influence of alcohol or any sleep-inducing, cough, and/ or allergy medication. This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly.

Uses of Talecalm Plus Tablet

Benefits of Talecalm Plus Tablet

Schizophrenia
Schizophrenia is a mental disorder in which a person’s thinking ability, feelings and behavior become abnormal. Talecalm Plus Tablet helps restore the chemical imbalances in the brain that are responsible for such changes. It improves thoughts, behavior and enhances the quality of life.

Side effects of Talecalm Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Talecalm Plus
  • Nausea
  • Constipation
  • Dryness in mouth
  • Sedation
  • Weight gain
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Urinary retention
  • Increased prolactin level in blood
  • Dizziness
  • Blurred vision
  • Nervousness

How to use Talecalm Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Talecalm Plus Tablet may be taken with or without food.

How Talecalm Plus Tablet works

Talecalm Plus Tablet is a combination of two medicines: Trifluoperazine and Trihexyphenidyl. Trifluoperazine is a typical antipsychotic. It works by blocking the action of a chemical messenger (dopamine) in the brain that affects thoughts and mood. However, it may cause side effects such as involuntary movements (shaking of hands, muscle spasms). Trihexyphenidyl is added to treat and prevent these side effects.

Quick tips

  • Talecalm Plus Tablet is a combination medicine that helps treat schizophrenia.
  • Be cautious while driving or doing anything that requires concentration as Talecalm Plus Tablet can cause dizziness and sleepiness.
  • It can cause dry mouth. Maintain good oral hygiene,drink water, chew sugarless gum, or suck on hard candy for the dry mouth.
  • It can make you more sensitive to changes in temperature. Drink plenty of liquids and dress appropriately.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • Inform your doctor if you have glaucoma or trouble passing urine.
  • Do not stop taking Talecalm Plus Tablet without talking to your doctor first as it may cause worsening of symptoms.

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Talecalm Plus Tablet may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Talecalm Plus Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Talecalm Plus Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Talecalm Plus Tablet may cause side effects that could affect your ability to drive.
Talecalm Plus Tablet can cause blurring of vision, dizziness, mild nausea, and mental confusion in some cases. This may affect your ability to drive.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Talecalm Plus Tablet in patients with kidney disease. Please consult your doctor.
Patients with kidney disease should be closely monitored by a doctor while taking this medicine.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Talecalm Plus Tablet in patients with liver disease.

Frequently asked questions

Everybody responds to the treatment differently. In general, it can take several weeks to feel the full benefits of Talecalm Plus Tablet, although some people may start to feel better sooner. It is important to give this drug the time to work.
No, you should continue taking Talecalm Plus Tablet even if you feel well. If you stop Talecalm Plus Tablet suddenly, serious withdrawal problems may occur. Your doctor will probably decrease your dose gradually before asking you to stop Talecalm Plus Tablet.
Yes, Talecalm Plus Tablet can make you feel sleepy. Avoid driving, operating machinery, working at heights or participating in potentially dangerous activities till you know how this medicine affects you.
Yes, the use of Talecalm Plus Tablet can cause dry mouth. If you experience dry mouth, drink plenty of water. Take regular sips during the day and keep some water by your bed at night. You may use lip balm if your lips are also dry. Try to avoid foods that are acidic (like lemons), spicy and salty.
Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Fact Box

Habit Forming

No

Therapeutic Class

NEURO CNS
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User feedback

Once A Day
46%
Twice A Day
41%
Four Times A Day
5%
Thrice A Day
5%
Alternate Day
3%
Schizophrenia
88%
Others
12%
Average
33%
Excellent
33%
Poor
33%
No Side Effect
50%
Sleepiness
50%
With food
100%
Expensive
100%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Talent India
Address: 1601, Karnavati Estate, GIDC, Phase III, Vatva, Ahmedabad 382445, Gujarat, India.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Talecalm Plus Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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