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Sistal Plus Tablet is a combination of two medicines. It is used to relieve pain and inflammation in conditions like rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It is also used to relieve muscle pain, back pain, toothache, or pain in the ear and throat.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 16 Mar 2026 | 04:08 PM (IST)
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Sistal Plus Tablet
Sistal Plus Tablet
strip of 10 tablets
₹11.1 per tablet
₹131
₹135.94
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₹111

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₹1200
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by BestoChem Formulations India Ltd
9% lower price
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Chymofine Plus 50mg/50000IU Tablet
Chymofine Plus 50mg/50000IU Tablet
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₹10.07 per tablet
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₹227
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by Morepen Laboratories Ltd
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General Information

Contains

Diclofenac (50mg)+ Trypsin Chymotrypsin (50000IU)

Marketer

BestoChem Formulations India Ltd

Storage

Store below 25°C
The content is shown in English
Sistal Plus Tablet image
Sistal Plus Tablet image
Sistal Plus Tablet image
Sistal Plus Tablet image

Product introduction

Sistal Plus Tablet is to be taken with food. This will prevent you from getting an upset stomach. The dose will depend on what you are taking it for and how well it helps your symptoms. You should take it as advised by your doctor. Do not take more or use it for longer duration than recommended by the doctor.

The most common side effects of this medicine include nausea, vomiting, indigestion, heartburn, stomach pain, loss of appetite, and diarrhea. If any of these side effects bother you or get worse, you should speak to your doctor. Your doctor may be able to suggest ways of preventing or reducing the side effects.

Before taking it, you should let your doctor know if you have a history of ulcer or bleeding in your stomach, high blood pressure, or have any trouble with your heart, kidneys, or liver. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.

Pregnant or breastfeeding women should consult their doctor before starting treatment. You should also avoid drinking alcohol while you are taking this medicine, as alcohol can cause excessive drowsiness.

Uses of Sistal Plus Tablet

Benefits of Sistal Plus Tablet

Pain relief
Sistal Plus Tablet is a combination of medicines that is used for short term relief of pain, inflammation and swelling. It inhibits release of those chemical messengers in the brain that tell us that we have pain. It effectively relieves back pain, earache, throat pain, toothache, periods pain and pain due to arthritis too.
Take Sistal Plus Tablet as prescribed by the doctor to get the most benefit. Do not take too much as it will only increase the risk of developing unpleasant side effects. In general, you should take the lowest dose that works, for the shortest possible time. This helps you lead a more active, comfortable and better quality of life.

Side effects of Sistal Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Sistal Plus
  • Nausea
  • Vomiting
  • Indigestion
  • Stomach pain
  • Loss of appetite
  • Diarrhea

How to use Sistal Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sistal Plus Tablet should be taken with or after food.

How Sistal Plus Tablet works

Sistal Plus Tablet is a combination of two medicines: Diclofenac and Trypsin Chymotrypsin which relieve pain and inflammation. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) which works by blocking the release of certain chemical messengers in the brain that are responsible for pain, fever and inflammation (redness and swelling). Trypsin Chymotrypsin is a combination of enzymes which break down proteins into smaller fragments, thereby making them available for absorption into the blood. Once absorbed, they increase blood supply in the affected area and reduce swelling.

All substitutes for Sistal Plus Tablet

For information purposes only. Consult a doctor before taking any medicine.

Chymofine Plus 50mg/50000IU Tablet

by Morepen Laboratories Ltd
₹11.87/tablet
9% cheaper
<h3 class=bodySemiBold>Chymofine Plus 50mg/50000IU Tablet</h3>

Chymoral Plus Tablet

by Torrent Pharmaceuticals Ltd
₹15.13/tablet
15% costlier
<h3 class=bodySemiBold>Chymoral Plus Tablet</h3>

Trydic D 50mg/50000IU Tablet

by Brostin Seizz Biocare
₹6.27/tablet
52% cheaper
<h3 class=bodySemiBold>Trydic D 50mg/50000IU Tablet</h3>

Trypcet-D Tablet

by Zenberg Pharmaceutical Pvt Ltd
₹8.87/tablet
32% cheaper
<h3 class=bodySemiBold>Trypcet-D Tablet</h3>

Quick tips

  • Sistal Plus Tablet helps relieve pain and inflammation.
  • Take it with food to help prevent an upset stomach.
  • Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious side effects.
  • It may cause dizziness, drowsiness or visual disturbances. Use caution while driving or doing anything that requires concentration.
  • Avoid consuming alcohol while taking this medicine as it can cause excessive drowsiness and increase your risk of stomach problems.
  • Inform your doctor if you have a history of heart disease, stroke, liver or kidney disease or problems with your blood clotting mechanism.
  • Your doctor may regularly monitor your kidney function, liver function and levels of blood components if you are taking this medicine for long-term treatment.

Safety advice

Alcohol

Alcohol

CAUTION
Alcohol should be used with caution while taking Sistal Plus Tablet.
Pregnancy

Pregnancy

UNSAFE
Sistal Plus Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

UNSAFE
Sistal Plus Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

UNSAFE
Sistal Plus Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Sistal Plus Tablet may cause headaches, blurred vision, dizziness or drowsiness in some patients. This may affect your ability to drive.
Kidney

Kidney

UNSAFE
Sistal Plus Tablet is unsafe to use in patients with kidney disease and should be avoided.
Liver

Liver

UNSAFE
Sistal Plus Tablet is unsafe to use in patients with liver disease and should be avoided.
Regular monitoring of liver function tests is recommended in patients with liver disease if this medicine is to be taken for a long time.

Frequently asked questions

No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having some serious side effects and toxicity. If you experience increased severity of your symptoms that are not relieved by the recommended doses, please consult your doctor for re-evaluation.
The use of Sistal Plus Tablet is considered to be harmful in patients with known allergy to any of the components or excipients of this medicine. The use of this medicine should preferably be avoided in patients with a history of stomach ulcers or in patients with active, recurrent stomach ulcer / bleeding. It should also be avoided in patients with history of heart failure, high blood pressure, and liver or kidney disease.
Yes, Sistal Plus Tablet does expire. Please check the expiry date written on the pack of this medicine. Do not use Sistal Plus Tablet after the expiry date.
Sistal Plus Tablet is a combination of three medicines: Diclofenac, Trypsin and Chymotrypsin. This medicine helps in decreasing pain and swelling. It lowers the levels of chemical substances in the body that cause pain and swelling.
No, there are no reports of any patient getting addicted to Sistal Plus Tablet
Sistal Plus Tablet is usually used for short term and can be discontinued when your pain is relieved. However, Sistal Plus Tablet should be continued if you are advised by your doctor to do so.
Yes, the use of Sistal Plus Tablet can cause dizziness (feeling faint, weak, unsteady or lightheaded) in some patients. If you feel dizzy or lightheaded, stop what you are doing and sit or lie down for sometime or until you feel better and do not drive or use any machines.
Yes, long-term use of Sistal Plus Tablet can cause damage to the kidneys. Normal kidneys produce a chemical called prostaglandins that protects them from damage. Use of painkillers lowers the levels of prostaglandins in the body leading to kidney damage on long-term use. Use of painkillers is not recommended to patients with underlying kidney disease.
It may take about an hour to notice the initial benefits of pain relief after taking Sistal Plus Tablet.
If you forget to take the scheduled dose of Sistal Plus Tablet and it is almost time for your next dose, skip the dose you missed and take your next dose at the scheduled time. Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally. Do not take a double dose to make up for the dose you missed because this may increase the risk of unwanted side effect due to overdosage. If you are not sure what to do, consult your doctor about how to manage a situation like this.

Fact Box

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

References

  1. ScienceDirect. Trypsin Chymotrypsin. [Accessed 02 Apr. 2019] (online) Available from:
  2. Diclofenac. Rouse Boulevard, Philadelphia: Iroko Pharmaceuticals; 1998 [revised Oct. 2013]. [Accessed 19 Apr. 2019] (online) Available from:
  3. Shah D, Mital K. The Role of Trypsin:Chymotrypsin in Tissue Repair. Adv Ther. 2018;35(1):31-42. [Accessed 02 Apr. 2019] (online) Available from:
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User feedback

Twice A Day
89%
Thrice A Day
6%
Once A Day
6%
Pain relief
50%
Others
33%
Headache
17%
Excellent
60%
Average
40%
No Side Effect
100%
With food
50%
With or without food
50%
Expensive
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Not Expensive
50%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: BestoChem Formulations India Ltd
Address: G-54 3rd FLOOR LAXMI NAGAR VIKAS MARG DELHI -110092

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Sistal Plus Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's â„ž and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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