Sireb L 75mg/40mg Tablet is a prescription medicine used in the treatment of gastroesophageal reflux disease (acid reflux). It works by relieving the symptoms such as heartburn, stomach pain, or irritation. It also neutralizes the acid production in the stomach to prevent discomfort.
Sireb L 75mg/40mg Tablet is taken without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you are taking as some may affect, or be affected by this medicine.
The most common side effects include diarrhea, nausea, vomiting, stomach pain, flatulence, constipation, and headache. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any side effects. To overcome constipation, you should add fibre-rich foods in your diet and stay hydrated. It may also cause sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can worsen your sleepiness. Lifestyle modifications like having cold milk and avoiding hot tea, coffee, spicy food or chocolate can help you to get better results.
Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy or breastfeeding. You should also tell your doctor if you have liver or kidney diseases so that your doctor can prescribe a suitable dose for you.
In Treatment of Gastroesophageal reflux disease (Acid reflux)
Gastroesophageal reflux disease (GERD) is a chronic (long-term) condition in which there is an excess production of acid in the stomach. Sireb L 75mg/40mg Tablet reduces the amount of acid your stomach makes and relieves the pain associated with heartburn and acid reflux. You should take it exactly as it is prescribed for it to be effective. Some simple lifestyle changes can help reduce the symptoms of GERD. Think about what foods trigger heartburn and try to avoid them; eat smaller, more frequent meals; try to lose weight if you are overweight and try to find ways to relax. Do not eat within 3-4 hours of going to bed.
Side effects of Sireb L Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Sireb L
Nausea
Vomiting
Diarrhea
Constipation
Upset stomach
Stomach pain
Headache
Flatulence
Sleepiness
Fundic gland polyps
How to use Sireb L Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sireb L 75mg/40mg Tablet is to be taken empty stomach.
How Sireb L Tablet works
Sireb L 75mg/40mg Tablet is a combination of two medicines: Levosulpiride and Esomeprazole.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Sireb L 75mg/40mg Tablet.
Pregnancy
CONSULT YOUR DOCTOR
Sireb L 75mg/40mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Sireb L 75mg/40mg Tablet during breastfeeding is not available. Please consult your doctor.
Driving
UNSAFE
Sireb L 75mg/40mg Tablet may cause side effects which could affect your ability to drive. Sireb L 75mg/40mg Tablet may cause drowsiness, numbness, or dyskinesias, therefore they should be advised to avoid driving and operations requiring supervision.
Kidney
CONSULT YOUR DOCTOR
There is limited information available on the use of Sireb L 75mg/40mg Tablet in patients with kidney disease. Please consult your doctor. However, limited data suggest a cautious use of this medicine in these patients.
Liver
CAUTION
Sireb L 75mg/40mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Sireb L 75mg/40mg Tablet may be needed. Please consult your doctor.
What if you forget to take Sireb L Tablet?
If you miss a dose of Sireb L 75mg/40mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
It is a well-tolerated medicine and provides relief for a long time.
Take it one hour before the meal, preferably in the morning.
Inform your doctor if you get watery diarrhea, fever, or stomach pain that does not go away.
Do not consume alcohol while taking Sireb L 75mg/40mg Tablet as it can increase the risk of stomach damage.
Long-term use may cause weak or broken bones. Take adequate intake of dietary calcium and vitamin D or their supplements. Do not take Sireb L 75mg/40mg Tablet for longer than prescribed.
Heartburn Mental disorder Depression Frequent persistent heartburn Gastroesophageal reflux disease Irritable bowel syndrome Indigestion Back flow of acid from stomach Difficulty in swallowing Inflammation of esophagus Excess acid secretion by stomach Intestinal or stomach ulcers
Dr. Sunil Sekhri
Diabetology
You need to be examined in clinic to reach a diagnosis and then appropriate medicine can be prescribed
My cough is not getting cured since 4-6 months. Tried some doctors, their medicines work for some time and the dry cough starts again. Though it happens occasionally, but i still cough
Dr. Shubhra Chandan Pradhan
ENT
It can be allergic cough or acid reflux disease. Can't give more opinion without seeing
Q. What are the instructions for storage and disposal of Sireb L 75mg/40mg Tablet?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Q. What is the best time to take Sireb L 75mg/40mg Tablet?
Take Sireb L 75mg/40mg Tablet exactly as directed by your doctor. It is best to take one capsule daily on an empty stomach.
Q. What are the contraindications associated with the use of Sireb L 75mg/40mg Tablet?
The use of Sireb L 75mg/40mg Tablet should be avoided in patients with known allergy to any of the components or excipients of this medicine.
Q. Can the use of Sireb L 75mg/40mg Tablet cause dizziness?
Yes, the use of Sireb L 75mg/40mg Tablet can cause dizziness (feeling faint, weak, unsteady or lightheaded) in some patients. If you feel dizzy or lightheaded, it is better to rest for some time and resume once you feel better.
Q. Does the use of Sireb L 75mg/40mg Tablet lead to increased risk of fractures?
Several studies in adults suggest that treatment with Sireb L 75mg/40mg Tablet may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist or spine. The risk of fracture was increased in patients who received high dose. High dose can mean multiple daily doses, and long-term therapy (a year or longer).
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References
Drugs.com. Esomerprazole. [Accessed 12 Apr. 2019] (online) Available from:
ScienceDirect. Levosulpiride. [Accessed 12 Apr. 2019] (online) Available from:
Esomeprazole DR and Levosulpiride ER [Patient Information Sheet]. Haridwar, Uttarakhand: Torrent Pharmaceuticals Ltd.; 2020. [Accessed 28th Sept. 2023] (online) Available from:
The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.