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Siphene -M Tablet 1
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Siphene -M Tablet 3
Siphene -M Tablet 4

Siphene -M Tablet

Clomiphene (25mg)
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Product Summary :

Siphene -M Tablet is a medicine containing clomiphene. It is used for certain types of female infertility when ovulation does not occur properly. It works by stimulating the ovaries to release an egg, improving the chance of pregnancy. It is usually taken for 5 days during the menstrual cycle. Common side effects include flushing, nausea, headache, and bloating. It may increase the chance of multiple pregnancy. 


Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 05 Oct 2026 | 01:01 AM (IST)
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Siphene -M Tablet 1
Siphene -M Tablet 2
Siphene -M Tablet 3
Siphene -M Tablet 4

Product introduction

Siphene -M Tablet is a medicine used to treat male and female infertility. In males, it stimulates hormone production, leading to increased sperm production and improved fertility. Additionally, it may help women who are unable to become pregnant due to ovulation problems or polycystic ovary syndrome (PCOS).

You can take Siphene -M Tablet with or without food or drink. If you want to get the most out of it, take it every day at the same time. Following the exact plan and amount instructions is very important if you want to get the most out of it. If needed, the doctor may change the dose based on regular monitoring of the reaction.


Most people who take this medicine may experience headaches, dizziness, breast enlargement in men, breast pain, hot flushes, ovarian enlargement, and gastrointestinal disturbances. You should tell your doctor about any of these side effects that do not go away or get worse. They might be able to help by changing the amount you take or giving you a different medicine.


Some medical problems, like liver disease, hormonal imbalances, abnormal uterine bleeding, or ovarian cysts, may mean that Siphene -M Tablet is not right for those people. Women who are pregnant should not take this medicine because it could harm the developing baby. Because this medicine might make you dizzy, be careful doing things that need clear vision and mental alertness. For safety reasons, you should also tell your doctor about all the other drugs you are taking.

Uses of Siphene Tablet

  • Female infertility : Used in women who have difficulty becoming pregnant because they do not release eggs regularly or properly.

Benefits of Siphene Tablet

Female infertility
Female infertility can sometimes occur when the ovaries do not release an egg regularly, making natural conception difficult. Siphene -M Tablet stimulates the ovaries to release an egg (ovulation), helping improve the chance of pregnancy in women whose infertility is related to problems with ovulation.

How to use Siphene Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Siphene -M Tablet may be taken with or without food.

How Siphene Tablet works

Siphene -M Tablet makes two hormones come out more: luteinizing hormone (LH) and follicle-stimulating hormone (FSH). When FSH and LH levels rise in females, they cause eggs (ovarian follicles) to grow and mature, which eventually leads to ovulation. These hormones are very important for men because they tell the testes to make more testosterone, which increases sperm production.

Dosage

Your doctor will tell you when during your menstrual cycle to start Siphene -M Tablet. The usual first treatment course is once daily for 5 days. If this does not result in ovulation, your doctor may prescribe two doses once daily for 5 days for the next course, starting at least 30 days after the first course. Treatment is usually limited to a maximum of 3 courses if ovulation does not occur. Do not change the dose yourself.

Quick tips

  • If you are male and taking Siphene -M Tablet, your doctor may recommend semen analysis tests during the treatment.
  • Follow your doctor's instructions regarding the dosage and schedule for taking Siphene -M Tablet.
  • If you are using Siphene -M Tablet for ovulation induction, your doctor may recommend tracking ovulation at home using ovulation predictor kits or monitoring body temperature. This can help you plan intercourse or any fertility treatments.
  • Clomiphene treatment is often limited to a specific number of cycles. If pregnancy does not occur after a certain number of cycles, your healthcare provider may explore other fertility treatments or interventions.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Siphene -M Tablet. Please consult your doctor.
Pregnancy

Pregnancy

UNSAFE
Siphene -M Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Siphene -M Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Siphene -M Tablet may cause temporary visual disturbances. Do not drive until your vision is clear.
Visual disturbances or dizziness might occur and should avoid engaging in activities requiring full concentration until the effects are better understood.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Siphene -M Tablet in patients with kidney disease. Please consult your doctor.
Liver

Liver

UNSAFE
Siphene -M Tablet is unsafe to use in patients with liver disease and should be avoided.
All

Frequently asked questions

Yes, Siphene -M Tablet may lead to multiple pregnancy or twins. The more the dose, the greater the chance of twins.
If you still cannot get pregnant after 6 treatment cycles, your doctor may want to reevaluate you and may suggest more advanced fertility treatments (IVF or IUI), more tests (HSG or surgery), and different medicines.
Your doctor may perform a baseline ultrasound (to check for cysts) and confirm ovulation by ultrasound or progesterone test.
If you find out you are pregnant, if you start having vision problems, or after six failed ovulation cycles, your doctor may tell you to stop treatment.
Yes. Siphene -M Tablet is not recommended for use in individuals who have a liver disorder.

Fact Box

Chemical Class

Stilbenes

Habit Forming

No

Therapeutic Class

GYNAECOLOGICAL

Action Class

Selective Estrogen Receptor Modulators (SERMs)- Ovulation Stimulants

References

  1. Schimmer BP, Parker KL. Contraception and Pharmacotherapy of Obstetrical and Gynecological Disorders. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1841-43.
  2. Chrousos GP. The Gonadal Hormones & Inhibitors. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 718-19.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 296-98.
  4. Mbi Feh MK, Wadhwa R. Clomiphene. [Updated 2022 Jun 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. [Accessed 25 Aug. 2023]. (online) Available from:
  5. Da Ros CT, Averbeck MA. Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study. Int Braz J Urol. 2012;38(4):512-8. [Accessed 25 Aug. 2023]. (online) Available from:
  6. Clomiphene. Bridgewater, New Jersey: Sanofi-Aventis U.S.; 2012. [Accessed 25 Aug. 2023] (online) Available from:
  7. Clomiphene citrate [Patient Information Leaflet]. Bridgewater, NJ: Sanofi-Aventis U.S. LLC; 2012. [Accessed 25 Jul. 2024] (online) Available from:
  8. Clomiphene citrate. Raleigh, NC: Accord Healthcare, Inc.; 2025
  9. Clomifene citrate. Bourgoin-Jallieu, France: Patheon France SAS; 2025. [Accessed 04 Oct. 2026] (online). Available from:
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User feedback

Once A Day
92%
Twice A Day
6%
Once A Month
1%
Twice A Week
1%
Others
69%
Female infertility
31%
Poor
52%
Average
29%
Excellent
19%
No Side Effect
100%
With food
100%
Average
78%
Expensive
22%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Serum Institute Of India Ltd
Address: 212/2, Hadapsar, Off Soli Poonawalla Road, Pune 411028 India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Siphene -M Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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