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Sigrima 420mg Injection 1
Sigrima 420mg Injection 2
Sigrima 420mg Injection 3
Sigrima 420mg Injection 4

Sigrima 420mg Injection

Pertuzumab (420mg/14ml)
Genuine
Authenticity Assured
Prescription
required
Cold stored
Stored between 2-8°C
Sigrima 420mg Injection is used to treat breast cancer. It belongs to group of medicine called monoclonal antibodies.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 13 Oct 2026 | 01:02 AM (IST)
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MRP ₹74995
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14 ml Injection
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Product expires after Jan, 2027

Expiry date may vary by batch. All batches have a 3-month shelf life from the date of dispatch.

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General Information

Contains

Pertuzumab (420mg/14ml)

Marketer

Zydus Lifesciences Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.
The content is shown in English
Sigrima 420mg Injection 1
Sigrima 420mg Injection 2
Sigrima 420mg Injection 3
Sigrima 420mg Injection 4

Product introduction

Sigrima 420mg Injection is given as an injection into veins under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Hair loss, diarrhea, nausea, and fatigue are some common side effects of this medicine. This medicine may reduce the number of blood cells (decrease white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with the heart, liver, and kidney.

Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Sigrima Injection

Benefits of Sigrima Injection

Breast cancer
Breast cancer is a disease in which cells in the breast grow uncontrollably, potentially spreading to nearby tissues or other parts of the body. Sigrima 420mg Injection is used along with other cancer medicines to slow or stop the growth of cancer cells, shrink tumors, and help improve survival outcomes in people with certain types of breast cancer.

Side effects of Sigrima Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Sigrima
  • Cough
  • Diarrhea
  • Dizziness
  • Fatigue
  • Feeling sick
  • Stomach inflammation
  • Hair loss
  • Heartburn
  • Muscle pain
  • Rash
  • Decreased blood cells (red cells, white cells, and platelets)
  • Breathlessness

How to use Sigrima Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Sigrima Injection works

Sigrima 420mg Injection is a monoclonal antibody designed to recognize and attach to specific proteins on the surface of cancer cells. Sigrima 420mg Injection gets attached to human epidermal growth factor receptor 2( HER2) and may kill or stop the growth of cancer cells.

Quick tips

  • Sigrima 420mg Injection is used in combination with other medicines for the treatment of breast cancer.
  • Do not receive any kind of immunization or vaccination without your doctor’s approval while taking Sigrima 420mg Injection.
  • Use contraceptives, and do not conceive a child (get pregnant) while taking Sigrima 420mg Injection. Barrier methods of contraception, such as condoms should be used during therapy and for 6 months after treatment. 
  • Drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise.
  • You may be at risk of infection so try to avoid crowds or people with colds, and report fever or any other signs of infection immediately to your health care provider.
  • To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals.
  • Take anti-diarrhea medication as prescribed by your doctor and eat foods that may help control diarrhea.
  • Avoid sun exposure. Wear SPF 15 (or higher) sunblock and protective clothing.
  • Inform your doctor if you are pregnant or breastfeeding before taking Sigrima 420mg Injection.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Sigrima 420mg Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Sigrima 420mg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

UNSAFE
Sigrima 420mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

UNSAFE
Sigrima 420mg Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Sigrima 420mg Injection in patients with kidney disease. Please consult your doctor.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Sigrima 420mg Injection in patients with liver disease.

Interaction with drugs

Taking Sigrima with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Do not use Pertuzumab with Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted).
Severe

Cholera Vaccine (Inactivated) (Oral Route)

Do not use Pertuzumab with Cholera Vaccine (Inactivated).
Severe

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Do not use Pertuzumab with Purified Vi Polysaccharide Typhoid Vaccine.

Fact Box

Chemical Class

Peptides

Habit Forming

No

Therapeutic Class

ANTI NEOPLASTICS

Action Class

HER2/neu Receptor Antagonist

References

  1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1095.
  2. Pertuzumab [FDA Label]. South San Francisco, CA: Genentech, Inc.; 2012. [Accessed 05 Feb. 2020] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Zydus Lifesciences Ltd
Address: Zydus Corporate Park, 4Th Floor, B Wing, Plot No 103, Near Nirma University,S G Highway, Ahmedabad, 382481 / Scheme No. 63, Survey No. 536, Khoraj(Gandhinagar), Near Vaishnodevi Circle, Ahmedabad - 382481, Gujarat.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Sigrima 420mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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