Sersam Plus 50mg/0.25mg Tablet

Sertraline (50mg)+ Clonazepam (0.25mg)

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Sersam Plus 50mg/0.25mg Tablet is a medicine used in the treatment of depression, panic disorder, anxiety disorder, obsessive-compulsive disorder, post-traumatic stress disorder, and premenstrual dysphoric disorder. It helps calms the brain and improves the mood and physical symptoms of the disease.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 31 Mar 2026 | 02:32 PM (IST)

₹88.6 MRP ₹98.4410% off

As per Ministry of Health and Family Welfare

Gurgaon

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General Information

Contains

Sertraline (50mg)+ Clonazepam (0.25mg)

Marketer

Origin Health Care Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Sersam Plus 50mg/0.25mg Tablet may be taken with or without food. Take it regularly and at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the exact dose and duration as advised by your doctor. If you have missed a dose, take it as soon as you remember it and finish the full course of treatment even if you feel better. You should not stop this medicine suddenly without talking to the doctor.

Some common side effects of this medicine include dizziness, dry mouth, palpitations, and memory impairment. It is important to inform your doctor if you develop any unusual changes in mood or depression as this medicine may cause suicidal thoughts.

Uses of Sersam Plus Tablet

Benefits of Sersam Plus Tablet

Treatment of Depression
Sersam Plus 50mg/0.25mg Tablet helps in maintaining the level of certain chemicals (such as serotonin) in the brain that affect mood and behavior. This creates a feeling of wellbeing, may help restore your interest in daily living and increases your energy levels. With Sersam Plus 50mg/0.25mg Tablet, you may experience fewer episodes of depression and low mood. Exercise and a healthy diet can also improve your mood. Take Sersam Plus 50mg/0.25mg Tablet exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Anxiety disorder
Sersam Plus 50mg/0.25mg Tablet helps relieve symptoms of anxiety disorder by increasing the level of a natural chemical (serotonin) in the brain. It may decrease fear, unwanted thoughts, tension, restlessness, calms your mind and helps you sleep well. Keep taking the medicine until your doctor advises you to stop. Regular meditation and yoga can help relax your mind and body.

Obsessive-compulsive disorder
Obsessive-compulsive disorder is a mental condition in which people have unwanted and repeated thoughts, feelings, ideas, sensations (obsessions) or the urge to do something over and over again (compulsions). These obsessions and compulsions can interfere with your daily activities. Sersam Plus 50mg/0.25mg Tablet helps in treating the symptoms of Obsessive-compulsive disorder and thus improves the quality of your life.

Post traumatic stress disorder
Post-traumatic stress disorder (PTSD) is a disorder that develops in some people who have experienced a shocking, frightening, or stressful event. Symptoms may include nightmares, flashbacks of the terrifying event, or severe anxiety. Sersam Plus 50mg/0.25mg Tablet helps decrease fear, anxiety, unwanted thoughts and improves sleep. It also prevents extreme changes in mood and helps you feel less agitated.

Panic disorder
With Sersam Plus 50mg/0.25mg Tablet, you may feel less afraid or anxious and have fewer panic attacks (sudden, unexpected attacks of extreme fear and worry). It can help you feel calmer and improve your ability to deal with problems. Do not stop taking it, even when you feel better unless your doctor advises you to. Change in diet and lifestyle can help overcome panic attacks.

Premenstrual dysphoric disorder
Premenstrual dysphoric disorder (PMDD) is a condition in which a woman has severe depression symptoms, irritability, anger and tension before her periods (menstruation). Sersam Plus 50mg/0.25mg Tablet helps you feel calm and improves your mood. It works by increasing the amounts of a natural substance in the brain (serotonin) that helps maintain mental balance. Indulging in some relaxation therapy, meditation and yoga might also provide you relief.

Side effects of Sersam Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Sersam Plus

Dizziness
Dryness in mouth
Palpitations
Memory impairment

How to use Sersam Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sersam Plus 50mg/0.25mg Tablet may be taken with or without food.

How Sersam Plus Tablet works

Sersam Plus 50mg/0.25mg Tablet is a combination of two medicines : Sertraline and Clonazepam. Sertraline is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the levels of serotonin, a chemical messenger in the brain. This improves mood and physical symptoms of depression and also relieves symptoms of post traumatic stress disorder, obsessive-compulsive disorder, panic disorder, premenstrual dysphoric disorder and anxiety. Clonazepam is a benzodiazepine. It works by increasing the action of a chemical messenger (GABA) which suppresses the abnormal and excessive activity of the nerve cells in the brain.

Quick tips

You have been prescribed Sersam Plus 50mg/0.25mg Tablet in order to improve your mental health and manage your depression, anxiety, mood disorders.
You may feel that Sersam Plus 50mg/0.25mg Tablet is not helping you straightaway. This is because it can take few weeks before you feel the full benefit. It is important that you continue to take it.
Inform your doctor immediately if you get thoughts about harming yourself or ending your life.
Avoid taking antacids 2 hours before or after taking Sersam Plus 50mg/0.25mg Tablet as they make it harder for your body to absorb the medicine.
If you have diabetes, you will be asked to monitor your blood glucose level regularly as this medicine may affect the levels of sugar in your blood.
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Sersam Plus 50mg/0.25mg Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

Sersam Plus 50mg/0.25mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

UNSAFE

Sersam Plus 50mg/0.25mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Sersam Plus 50mg/0.25mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Sersam Plus 50mg/0.25mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

UNSAFE

Sersam Plus 50mg/0.25mg Tablet is unsafe to use in patients with liver disease and should be avoided.

Fact Box

Habit Forming

Therapeutic Class

NEURO CNS

References

Bonate PL, Kroboth PD, Smith RB, et al. Clonazepam and sertraline: absence of drug interaction in a multiple-dose study. J Clin Psychopharmacol. 2000 Feb;20(1):19-27. [Accessed 31 Jan. 2026]. Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Manufacturer details

Name: A)Pure & Cure Healthcare Pvt. Ltd. (A subsidiary of Akums Drugs & Pharmaceuticals Ltd.)
Address: A)Plot No. 26A, 27-30, Sector-8A, I.I.E., SIDCUL, Ranipur, Haridwar-249 403, Uttarakhand/Vill. Manakpur, P.O. Lodhimajra, Baddi-173 205, Distt.-Solan, (H.P.)

Marketer details

Name: Origin Health Care Pvt Ltd
Address: H.No.16-310/6/1/1Asaleem Nagar, Musharambagh, Hyderabad-2, Telangana

Vendor Details

Country of origin: India

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Sersam Plus 50mg/0.25mg Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Sersam Plus Tablet

Benefits of Sersam Plus Tablet

Side effects of Sersam Plus Tablet

How to use Sersam Plus Tablet

How Sersam Plus Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Fact Box

Habit Forming

Therapeutic Class

References

Want to know more

Have issue with the content

Disclaimer

Manufacturer details

Marketer details

Vendor Details

Lab tests offered by us

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