Roff 25mg Injection

Rofecoxib (25mg)

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Roff 25mg Injection is a pain relieving medicine. It effectively alleviates pain, inflammation, and stiffness in various forms of arthritis, migraine, acute pain conditions, and menstrual pain. It is generally used in cases where oral administration is unsuitable.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 29 Apr 2026 | 11:11 AM (IST)

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General Information

Contains

Rofecoxib (25mg)

Marketer

Torrent Pharmaceuticals Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Roff 25mg Injection is generally administered by a healthcare professional. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep receiving the medicine until the doctor says it is okay to stop using the medicine.

The most common side effects of this medicine include abdominal pain, upper respiratory infection, diarrhea, heartburn, nausea, and headache, and injection site reactions (such as pain, redness, and swelling). If any of these side effects persist or get worse, you should let your doctor know.

Before taking it, you should let your doctor know if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.

This medicine is not recommended for pregnant or breastfeeding women. It is very important that pregnant and breastfeeding mothers consult with their doctors before using the medicine.

Uses of Roff Injection

Pain relief

Benefits of Roff Injection

Pain relief
Roff 25mg Injection helps to relieve pain, inflammation and swelling in conditions that affect joints and muscles. It works by blocking chemical messengers in the brain that tell us we have pain. It can help relieve pain in conditions like rheumatoid arthritis, migraine, menstrual pain, and osteoarthritis.
It is given as an injection by a doctor or nurse and should not be self-administered. The dose and duration will be decided by the doctor depending on the condition you are being treated for. This will help you to go about your daily activities more easily and have a better, more active, quality of life.

Side effects of Roff Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Roff

Abdominal pain
Diarrhea
Nausea
Headache
Heartburn
Upper respiratory tract infection
Injection site reactions (pain, swelling, redness)

How to use Roff Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Roff Injection works

Roff 25mg Injection is a non-steroidal anti-inflammatory drug (NSAID) called COX-2 inhibitors. It works by blocking the release of certain chemical messengers that are responsible for pain and inflammation (redness and swelling).

Quick tips

Roff 25mg Injection helps relieve pain and inflammation.
It may cause fewer stomach problems as compared to other NSAIDs like Ibuprofen or Naproxen.
It may cause dizziness and fatigue. Do not drive or do anything requiring concentration until you know how it affects you.
Do not consume alcohol while on treatment with this medicine as it may cause excessive drowsiness.
Regularly monitor your blood pressure while taking this medicine, particularly in the first two weeks after starting treatment.
Inform your doctor if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease.
During long-term treatment, your doctor may want to take regular blood tests to monitor your liver function.
Do not take Roff 25mg Injection if you are pregnant, planning to conceive, or breastfeeding.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Roff 25mg Injection.

Pregnancy

CONSULT YOUR DOCTOR

Roff 25mg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

UNSAFE

Roff 25mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Roff 25mg Injection may cause side effects that could affect your ability to drive.

Kidney

UNSAFE

Roff 25mg Injection is unsafe to use in patients with kidney disease and should be avoided.
Use of Roff 25mg Injection is not recommended in patients with severe kidney disease.

Liver

CAUTION

Roff 25mg Injection should be used with caution in patients with severe liver disease. Dose adjustment may be needed.
Use of Roff 25mg Injection is not recommended in patients with moderate to severe liver disease.

Frequently asked questions

What is Roff 25mg Injection used for?

Roff 25mg Injection is a pain-relieving medicine used to reduce pain, inflammation, and stiffness in conditions like arthritis, migraines, acute pain episodes, and menstrual pain. It is especially helpful when oral medicines cannot be taken.

How quickly will Roff 25mg Injection start working?

You should begin to feel pain relief within 1 hour after receiving Roff 25mg Injection. The full pain relief may take longer to become apparent.

How long will the pain relief from one Roff 25mg Injection last?

A single Roff 25mg Injection typically provides pain relief for about 16 to 20 hours. The medicine is formulated to have an effective half-life of approximately 17 hours, meaning it stays active in your body for a significant period.

Where on the body is Roff 25mg Injection typically given?

Roff 25mg Injection is administered as an intramuscular injection, which means it is injected directly into a large muscle. Your doctor or nurse will select a suitable site for the injection.

What should I make sure to tell my doctor before I get Roff 25mg Injection?

Before receiving Roff 25mg Injection, it is very important to inform your doctor if you have a history of heart disease. You must also tell them if you have ever had an allergic reaction, like a skin rash, or difficulty breathing, to aspirin, or other nonsteroidal anti-inflammatory drugs (NSAIDs).

Fact Box

Chemical Class

Stilbenes

Habit Forming

Therapeutic Class

PAIN ANALGESICS

Action Class

NSAID's -Selective COX-2 Inhibitors

References

Grosser T, Smyth E, FitzGerald GA. Anti-Inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 992.
Sciencedirect. Rofecoxib. [Accessed 02 Apr. 2019] (online) Available from:
Sciencedirect. Rofecoxib. [Accessed 02 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 02 Apr. 2019] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Torrent Pharmaceuticals Ltd
Address: Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India

Vendor Details

Country of origin: India

Lab tests offered by us

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Roff 25mg Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Roff Injection

Benefits of Roff Injection

Side effects of Roff Injection

How to use Roff Injection

How Roff Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Roff 25mg Injection used for?

How quickly will Roff 25mg Injection start working?

How long will the pain relief from one Roff 25mg Injection last?

Where on the body is Roff 25mg Injection typically given?

What should I make sure to tell my doctor before I get Roff 25mg Injection?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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