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Rofecoxib is used in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, gout, arthralgia, myalgia, pain during menstruation and post operative pain.

How it works

Rofecoxib blocks the release of certain chemical messengers that are responsible for pain and inflammation (redness and swelling).

Common side effects

Abdominal pain, Nausea, Vomiting, Headache, Gastritis, Edema, Constipation, Palpitations, Heartburn, Flatulence, Dizziness, Diarrhoea, Increased blood pressure, Dyspepsia

Available Medicine

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    Alkem Laboratories Ltd
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    Wockhardt Ltd
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    RPG Life Sciences Ltd
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    J B Chemicals and Pharmaceuticals Ltd
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    Sun Pharmaceutical Industries Ltd
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    Sun Pharmaceutical Industries Ltd
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    Cachet Pharmaceuticals Pvt Ltd
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    Comed Chemicals Ltd
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    Alembic Pharmaceuticals Ltd
    3 variant(s)

Expert advice

  • Inform your doctor before taking the drug if you are allergic to aspirin or other NSAIDs.
  • Stop taking rofecoxib and seek immediate medical attention if you develop: abdominal pain, tenderness, or discomfort; nausea; blood in your vomit; bloody, black, or tarry stools; unexplained weight gain; swelling or water retention; fatigue or lethargy; a skin rash; itching; yellowing of your skin or eyes; or unusual bruising or bleeding.
  • Tell your doctor if you have asthma, stomach problems such as ulcers or bleeding, kidney disease, liver disease, angina (chest pain), heart attack, or a blocked artery in the heart, heart failure, high blood pressure.

Frequently asked questions



Is rofecoxib deadly?
Rofecoxib is relatively safe if used as prescribed. In case of any side-effects, please consult your doctor


Is rofecoxib a narcotic?
No, rofecoxib is a nonsteroidal anti-inflammatory drugs (NSAIDs)


How does rofecoxib work?
Rofecoxib belongs to a group of medicines called COX-2 selective nonsteroidal anti-inflammatory drugs (NSAIDs). It works by inhibiting certain chemical called prostaglandin which is responsible for pain and inflammation.

Content on this page was last updated on 25 April, 2017, by Dr. Varun Gupta (MD Pharmacology)