Rifa I-6 E Kit is a combination of four medicines: Isoniazid, rifampicin, ethambutol and vitamin B6 (pyridoxine) which treat tuberculosis (TB). Isoniazid prevents the TB bacteria from forming their own protective covering while rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by these bacteria to make essential proteins and to reproduce. Together, they kill the bacteria and eradicate the infection. Ethambutol, on the other hand works by slowing the growth of these bacteria. Vitamin B6 (pyridoxine) is added to prevent nerve damage which may be a side effect of isoniazid.
Rifa I-6 E Kit may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions).
WEIGH RISKS VS BENEFITS
Rifa I-6 E Kit may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Rifa I-6 E Kit is safe to use during lactation.
Human studies have shown that either the drug does not pass into the breastmilk in significant amount or is not expected to cause toxicity to the baby.
Do not drive unless you are feeling well. Rifa I-6 E Kit occasionally causes sight problems and tingling or numbness in hand or feet. After taking this medicine you should not drive until you know how it affects you.
Rifa I-6 E Kit is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Rifa I-6 E Kit may not be needed in these patients. Please consult your doctor.
Rifa I-6 E Kit is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Rifa I-6 E Kit may not be needed in these patients. Please consult your doctor.