Content Details
Written By
PhD (Pharmacology), PGDPRA
Reviewed By
MD (Pharmacology), MBBS
Last updated on:
16 Jul 2019 | 05:13 PM (IST)
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Overview

Introduction

RF 4 Kit is a combination of four medicines. It is prescribed to treat Tuberculosis. It fights against the bacteria to kill the microorganisms.

RF 4 Kit is a prescription medicine. It can be taken with or without food. Take the medicine in the dose and duration advised by your doctor. Do not consume more than the recommended dose, as this may have harmful effects on your body. A missed dose should be taken as soon as you remember. The course of the treatment should be completed for better efficacy.

Some of the side effects of RF 4 Kit are nausea, vomiting, rashes, etc. You may also feel dizzy, thus it is advised not to drive or operate machinery. To overcome dizziness you should drink plenty of fluid. If any of the side effects get aggravated, contact your doctor immediately. In cases of severe liver or kidney disease, consult your doctor before you start with the treatment. Consumption of alcohol should be avoided while you are on the treatment.

Uses of RF 4 Kit

RF 4 Kit side effects

Common
  • Nausea
  • Vomiting
  • Rash
  • Fever
  • Dark colored urine
  • Sweating
  • Increased sputum production
  • Salivation
  • Teary eyes
  • Peripheral neuropathy (tingling and numbness of feet and hand)
  • Increased liver enzymes
  • Jaundice
  • Increased uric acid level in blood
  • Visual impairment

How to use RF 4 Kit

Take this medicine in the dose and duration as advised by your doctor. Check the label before use. RF 4 Kit is to be taken empty stomach.
Avoid RF 4 Kit with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

How RF 4 Kit works

RF 4 Kit is a combination of four medicines: Isoniazid, rifampicin, ethambutol and pyrazinamide which treat tuberculosis. Isoniazid works by preventing the TB bacteria from forming their own protective covering, while rifampicin inactivates a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce. Together, they kill the bacteria and eradicate the infection. Ethambutol and pyrazinamide on the other hand, work by slowing the growth of these bacteria.

RF 4 Kit related warnings

Alcohol
UNSAFE
Consuming alcohol while taking RF 4 Kit may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
Pregnancy
CONSULT YOUR DOCTOR
RF 4 Kit may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Lactation
SAFE IF PRESCRIBED
RF 4 Kit is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
UNSAFE
RF 4 Kit may cause side effects which could affect your ability to drive.
RF 4 Kit occasionally causes sight problems and tingling or numbness in hand or feet. After taking this medicine you should not drive until you know how it affects you.
Kidney
CAUTION
RF 4 Kit should be used with caution in patients with kidney disease. Dose adjustment of RF 4 Kit may be needed. Please consult your doctor.
Kidney function tests are advisable before the start of this medicine.
Liver
CAUTION
RF 4 Kit should be used with caution in patients with liver disease. Dose adjustment of RF 4 Kit may be needed. Please consult your doctor.
Regular monitoring of liver function tests is advised before and after the start of the treatment.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
RF 4 Kit
₹3.4/Kit
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Forecox Kit
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Anticox 4 Kit
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₹5.61/Kit
65% costlier
Afb 4 Kit
Lark Laboratories Ltd
₹14.61/Kit
330% costlier
CAVICIN E KIT
Wockhardt Ltd
₹18.79/Kit
453% costlier

Expert Advice

  • You have been prescribed RF 4 Kit for the treatment of tuberculosis.
  • Take it on an empty stomach and preferably at the same time everyday.
  • Try not to forget a dose, as this increases the risk of the bacteria becoming resistant to the medicine, and also increases the risk of getting side effects.
  • It may discolour your urine, sweat, saliva and tears a reddish/orange colour. This is normal and not harmful.
  • Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
  • Avoid drinking alcohol while taking RF 4 Kit as this may increase the risk of side effects on the liver.
  • It may cause vitamin B6 deficiency. Your doctor may prescribe vitamin B6 supplements to help avoid potential problems associated with its deficiency, such as inflammation of the nerves (neuritis). 
  • Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking RF 4 Kit as it may make hormonal contraceptives such as the pill less effective.
  • Do not take indigestion remedies (antacids)  within at least two hours of taking RF 4 Kit.
  • Finish the full course of the medication, even if you feel better. Stopping the course early increases the risk of coming back of the infection.

Patient Concerns

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User Feedback


FAQs

Q. Can the use of RF 4 cause discoloration of the urine?

Yes, RF 4 contains Rifampicin. It can cause temporary discoloration of your teeth, sweat, urine, saliva and tears (red, orange or brown color). This side effect is usually not harmful. However, discoloration of urine can be a sign of liver damage. Contact your doctor if you notice discoloration of urine accompanied with stomach pain, loss of appetite and jaundice (yellowing of your skin or eyes).

Q. Can RF 4 cause visual impairment?

RF 4 contains Ethambutol which may cause visual impairment. Inform the doctor immediately if you notice any changes in your eyesight.

Q. Can I discontinue RF 4 if I feel well?

No, do not discontinue RF 4. Take the proper course of a drug that has been prescribed for you even if you begin to feel better. If you stop taking RF 4 then your infection may become worse, difficult to treat and it may result in drug-resistant TB (drugs you are taking may no longer work).

Q. Can I take oral contraceptive pills while taking RF 4?

No, RF 4 can make birth control pills less effective. So, ask your doctor about using a birth control method which does not affect your hormone levels (such as a condom, diaphragm, spermicide).

Q. What are the instructions for storage and disposal of RF 4?

Keep this medicine in the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. How to take RF 4?

Take RF 4 on an empty stomach which means at least one hour before and two hours after a meal and with full glass of water.

Q. Can I drink alcohol while taking RF 4?

No, avoid drinking alcohol while taking RF 4. Drinking alcohol will increase the risk of hepatitis caused by RF 4 because of isoniazid.

Related Products

Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Gumbo T. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman's: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: The McGraw-Hill Companies, Inc.; 2011. [Accessed 09 Apr. 2019] (online) Available from:External Link
  2. Drugs.com. Rifampicin. [Accessed 09 Apr. 2019] (online) Available from:External Link
  3. Ethambutol. Ontario, Canada: Patheon Inc.; 2007. [Accessed 09 Apr. 2019] (online) Available from:External Link
  4. Drugs.com. Pyrazinamide. [Accessed 09 Apr. 2019] (online) Available from:External Link
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