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Profesam-ER Tablet

Written By Dr. Sakshi Jain, MS, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 25 Nov 2025 | 03:07 PM (IST)
Profesam-ER Tablet is a prescription medicine used to treat depression. It is a combination medicine that works by increasing the level of chemical messengers in the brain that improve mood. It also calms the brain by decreasing the abnormal and excessive activity of the nerve cells.
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General Information

Contains

Paroxetine (12.5mg)+ Clonazepam (0.5mg)

Marketer

Nugenra Pharma pvt ltd

Storage

Store below 30°C
The content is shown in English
Profesam-ER Tablet image
Profesam-ER Tablet image
Profesam-ER Tablet image

Product introduction

Profesam-ER Tablet can be taken with or without food. It is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. Take this medicine in the dose and duration advised by your doctor, as it has habit-forming potential. Try to never skip any doses, but if you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better. It is important not to stop taking this medicine suddenly, as it may result in withdrawal symptoms.


Some common side effects of this medicine include nausea, vomiting, confusion, memory impairment, low sexual desire, and delayed ejaculation. It may cause dizziness and sleepiness. So, do not drive or do anything that requires mental focus until you know how this medicine affects you. It is important to inform your doctor if you develop any unusual changes in mood or depression, as this medicine may cause suicidal thoughts.


Take caution while taking medicine if you are suffering from liver disease. Your doctor should also know about all other medicines you are taking, as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.

Uses of Profesam Tablet ER

Benefits of Profesam Tablet ER

Depression
Profesam-ER Tablet works by affecting the balance of certain chemicals (such as serotonin) in the brain. It helps improve mood and feelings of wellbeing, relieve anxiety and tension, helps you sleep better, and increase your energy level. It is an effective antidepressant but may cause drowsiness. You need to take it regularly as it is prescribed for it to be most effective and should not stop taking it suddenly.

Side effects of Profesam Tablet ER

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Profesam
  • Nausea
  • Vomiting
  • Diarrhea
  • Confusion
  • Memory impairment
  • Uncoordinated body movements
  • Drowsiness
  • Tiredness
  • Anorgasmia (decreased orgasm)
  • Low sexual desire
  • Delayed ejaculation
  • Sleepiness
  • Dryness in mouth
  • Constipation

How to use Profesam Tablet ER

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Profesam-ER Tablet may be taken with or without food.

How Profesam Tablet ER works

Profesam-ER Tablet is a combination of two medicines, paroxetine and clonazepam, which have mood-enhancing and anxiety-lowering effects. Paroxetine is a selective serotonin reuptake inhibitor (SSRI), which increases the levels of serotonin, a chemical messenger that improves mood. Clonazepam is a benzodiazepine (BZD) that increases the action of GABA, a chemical messenger that suppresses the abnormal activity of the nerve cells in the brain.

Quick tips

  • Take Profesam-ER Tablet with a snack or just after eating breakfast, as this will help to reduce the likelihood of you feeling sick as a side effect.
  • It can take a week or two after starting this treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit. Do not stop taking it after a week or two if you feel it is not helping.
  • Avoid taking antacids 2 hours before or after taking Profesam-ER Tablet, as they make it harder for your body to absorb the medicine.
  • Inform your doctor immediately if you have thoughts about harming yourself or ending your life.
  • If you have diabetes, you will be asked to monitor your blood glucose level regularly, as this medicine may affect the levels of sugar in your blood.
  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Profesam-ER Tablet
Pregnancy

Pregnancy

UNSAFE
Profesam-ER Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Profesam-ER Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Profesam-ER Tablet may cause side effects that could affect your ability to drive.
Kidney

Kidney

SAFE IF PRESCRIBED
Profesam-ER Tablet is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.
Use of Profesam-ER Tablet can cause excessive sleepiness in patients with end stage kidney disease.
Liver

Liver

CAUTION
Profesam-ER Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

Profesam-ER Tablet may increase suicidal thoughts or actions in some patients in the first few months of the treatment. Patients with mood or behavioral disorders have a high risk of suicidal thoughts and actions. You should pay close attention and report to your doctor any changes in behavior or mood. Make sure that you visit the doctor for the follow-up appointments as scheduled.
No, you should continue taking Profesam-ER Tablet even if you feel well. If you stop Profesam-ER Tablet suddenly, serious withdrawal symptoms may occur. Your doctor will probably decrease your dose gradually.
Some reports suggest that the use of Profesam-ER Tablet can cause weight gain. If you keep good eating habits and exercise regularly, you might not gain any weight. It is important to remember that it is easier to stop weight gain than to lose weight.
Yes, Profesam-ER Tablet can make you feel sleepy. Avoid driving, operating machinery, working at heights, or participating in potentially dangerous activities until you know how this medicine affects you.
The use of Profesam-ER Tablet can affect the sexual life of both men and women. Different sexual problems can occur due to Profesam-ER Tablet, like decreased sexual desire, erectile dysfunction (inability to develop or maintain an erection during sexual activity), and inability to reach orgasm. It can also cause a decrease in satisfaction and discomfort during intercourse. If you experience these problems, discuss them with your doctor.
No, do not drink alcohol while taking Profesam-ER Tablet. Drinking alcohol can increase the severity of drowsiness or sleepiness caused by Profesam-ER Tablet.
Everybody responds differently to treatment. In general, it can take several weeks to feel the full benefits of Profesam-ER Tablet, although some people may start to feel better sooner. When taking Profesam-ER Tablet, it is important to give it time to work.
Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, and other people.

Fact Box

Habit Forming

Yes

Therapeutic Class

NEURO CNS

References

  1. Paroxetine. Miami, Florida: Noven Therapeutics; 2003 [revised 06-2013]. [Accessed 23 Apr. 2019] (online) Available from:
  2. Clonazepam. Boucherville, Québec: Sandoz Canada Inc.; 2018. [Accessed 23 Apr. 2019] (online) Available from:
  3. Paroxetine. Roswell, Georgia: Sebela Pharmaceuticals Inc.; 2023. [Accessed 03 Apr. 2025] (online) Available from:
  4. Paroxetine hydrochloride [Product Information]. East Windsor, NJ: Aurobindo pharma USA Inc.; 2025. [Accessed 03 Apr. 2025] (online) Available from:
  5. Parpxetin and clonazepam. Mumbai, Maharashtra: Alkem Laboratories Limited.; [Accessed 03 Apr. 2025] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Nugenra Pharma pvt ltd
Address: Plot No-19,Industrial Area,Phase-2, Panchkula, Haryana,India ,contact number-+917310066000

Vendor Details

Country of origin: India

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