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Piptabrex 4.5 Injection is a combination of two antibiotics. It is used to treat various types of bacterial infections. It fights against the infection by killing the microorganisms.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 13 Oct 2025 | 04:22 PM (IST)
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General Information

Contains

Piperacillin (4000mg)+ Tazobactum (500mg)

Marketer

Mcbrex Lifesciences

Storage

Store below 30°C
The content is shown in English
Piptabrex 4.5 Injection image
Piptabrex 4.5 Injection image

Product introduction

Piptabrex 4.5 Injection is generally administered by a healthcare professional and should not be self-administered. Depending on the severity of your underlying illness, your doctor will decide the precise dose and schedule as per which this injection is to be given. It is strictly advised to be used as per the doctor’s prescription.

Some of the common side effects of this medicine include nausea, vomiting, diarrhea, and rash. Additionally, you may notice some injection site reactions like pain, swelling, or redness. You should consult your doctor if these side effects do not get better with time and persist for a longer duration.

Before using the medicine, you should tell your doctor if you are allergic to any antibiotics or have any kidney or liver problems. Your doctor may change the dose or prescribe a different medicine. This medicine is generally considered safe to use during pregnancy and breastfeeding if used under a doctor’s supervision.

Uses of Piptabrex Injection

Benefits of Piptabrex Injection

Bacterial infections
Piptabrex 4.5 Injection contains two different medicines that work together to kill the bacteria that cause infections. Piperacillin belongs to a group of medicines called penicillins that work by stopping the growth of bacteria. Tazobactam is a beta-lactamase inhibitor that reduces resistance and enhances the activity of Piperacillin against bacteria.

Piptabrex 4.5 Injection can be used to treat many different bacterial infections such as ear, sinus, throat, lung, urinary tract, skin, teeth, joints, and bones. This medicine usually makes you feel better within a few days, but you should continue taking it as prescribed even when you feel better to make sure that all bacteria are killed and do not become resistant.

Side effects of Piptabrex Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Piptabrex
  • Nausea
  • Vomiting
  • Diarrhea
  • Rash
  • Allergic reaction

How to use Piptabrex Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Piptabrex Injection works

Piptabrex 4.5 Injection is a combination of two medicines: Piperacillin and Tazobactum. Piperacillin is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Tazobactum is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Piperacillin against bacteria.

All substitutes for Piptabrex 4.5 Injection

For information purposes only. Consult a doctor before taking any medicine.

Pipzo 4.5 g Injection

by Alkem Laboratories Ltd
₹326.22/injection
15% cheaper
<h3 class=bodySemiBold>Pipzo 4.5 g Injection</h3>

Tazomac 4.5gm Injection

by Macleods Pharmaceuticals Pvt Ltd
₹282.5/injection
27% cheaper
<h3 class=bodySemiBold>Tazomac 4.5gm Injection</h3>

Tazar 4.5g Injection

by Lupin Ltd
₹300.1/injection
22% cheaper
<h3 class=bodySemiBold>Tazar 4.5g Injection</h3>

Maxotaz 4.5 g Injection

by Macleods Pharmaceuticals Pvt Ltd
₹282.5/injection
27% cheaper
<h3 class=bodySemiBold>Maxotaz 4.5 g Injection</h3>

Cidal 4000 mg/500 mg Injection

by Neon Laboratories Ltd
₹211.17/injection
45% cheaper
<h3 class=bodySemiBold>Cidal 4000 mg/500 mg Injection</h3>

Quick tips

  • You have been prescribed this combination medicine to treat bacterial infections even if they have developed resistance. 
  • Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
  • Diarrhea may occur as a side effect. Taking probiotics along with Piptabrex 4.5 Injection may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.
  • Stop taking Piptabrex 4.5 Injection and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.

Safety advice

Alcohol

Alcohol

SAFE
Consuming alcohol with Piptabrex 4.5 Injection does not cause any harmful side effects.
Pregnancy

Pregnancy

SAFE IF PRESCRIBED
Piptabrex 4.5 Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Piptabrex 4.5 Injection is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Piptabrex 4.5 Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney

Kidney

CAUTION
Piptabrex 4.5 Injection should be used with caution in patients with kidney disease. Dose adjustment of Piptabrex 4.5 Injection may be needed. Please consult your doctor.
Liver

Liver

SAFE IF PRESCRIBED
Piptabrex 4.5 Injection is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Piptabrex 4.5 Injection may not be needed in these patients. Please consult your doctor.

Frequently asked questions

Piptabrex 4.5 Injection is a combination of two medicines. It is used to treat bacterial infections like tonsillitis, sinusitis, otitis media, respiratory tract infections, urinary tract infections, boils, abscesses, cellulitis, wound infection, bone infection and oral cavity infections.
Piptabrex 4.5 Injection is safe to use when taken as advised by the doctor. However, in some patients, it may cause common side effects like diarrhea, nausea, vomiting, rash, allergic reaction, etc. If you experience any persistent problem while taking this medicine, inform your doctor as soon as possible.
Piptabrex 4.5 Injection should be administered under the supervision of a trained healthcare professional or a doctor only and should not be self-administered. The dose will depend on the condition you are being treated for and will be decided by your doctor. Follow your doctor’s instructions carefully to get maximum benefit from Piptabrex 4.5 Injection.
The use of Piptabrex 4.5 Injection is considered to be harmful for patients with known allergy to penicillins or any other ingredient of the medicine. It should not be used in patients with a history of liver disease. Therefore, consult your doctor before using Piptabrex 4.5 Injection.
Yes, the use of Piptabrex 4.5 Injection can lower the efficacy of birth control pills. Consult your doctor and seek advice regarding the use of other methods of contraception (e.g., condom, diaphragm, spermicide) while you are taking Piptabrex 4.5 Injection.
No, Piptabrex 4.5 Injection should be used in the recommended dose only. Overdose of Piptabrex 4.5 Injection can increase the risks of side effects. Piptabrex 4.5 Injection may take some time to show its full effect and treat your infection, be patient. If you experience increased severity of your symptoms, please consult your doctor for re-evaluation.
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Yes, Piptabrex 4.5 Injection can cause an allergic reaction. It is considered to be harmful for patients with known allergy to penicillins. Get emergency medical help if you have any signs of allergic reaction like hives, difficulty breathing, swelling of your face, lips, tongue or throat.
Yes, the use of Piptabrex 4.5 Injection can cause diarrhea. It is an antibiotic which kills the harmful bacteria. In addition to that, it can also affect the helpful bacteria in your stomach or intestine and cause diarrhea. In case you experience diarrhea, drink plenty of water or other fluids. Talk to your doctor if diarrhea persists and you notice any signs of dehydration, like less frequency of urination with dark colored and strong-smelling urine. Do not take any other medicine without consulting a doctor.

Fact Box

Habit Forming

No

Therapeutic Class

ANTI INFECTIVES

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

  1. Piperacillin sodium/tazobactum sodium. Wrexham: Wockhardt UK Ltd.; 2009 [revised 18 Jul. 2017]. [Accessed 09 Apr. 2019] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Mcbrex Lifesciences
Address: Plot No. 302, Second Floor, Phase 2, Industrial Area, Industrial Area Phase 2, Panchkula - 134113, Haryana, India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Piptabrex 4.5 Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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