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Pentashield Vaccine is a 5 in 1 vaccine given to infants and young children. It provides active immunization against five severe diseases namely Diphtheria, Haemophilus influenzae type b, Hepatitis-B, Pertussis, and Tetanus. It boosts the immune system and produces protective antibodies against these diseases.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 12 Mar 2026 | 12:42 PM (IST)
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Pentashield Vaccine image
Pentashield Vaccine image

Product introduction

Pentashield Vaccine is to be administered by your child’s doctor only. It is injected into the thigh muscles of infants. In older children, the vaccine is administered into the arm muscle. It is administered in 3 doses, each 4 weeks apart, preferably before the age of 6 months. Generally, it is recommended to administer the 1st dose at 6 weeks of age, the 2nd dose at 10 weeks of age, and the 3rd dose at 14 weeks of age. If a child has not received the 1st dose by the age of his initial year, start vaccination as soon as possible and consult your child’s doctor for the schedule.

Pentashield Vaccine can cause some minor and temporary side effects such as fever, irritation, loss of appetite, injection site reaction (pain, swelling, redness), and skin rash. However, these episodes do not last very long and subside on their own. If worrisome, do seek the doctor's help.

Talk to your child’s doctor before vaccination if your child has a history of liver problems, kidney problems, blood disorders, birth defects, heart problems, lung problems, severe pain or swelling of the limbs, or Guillain-Barré syndrome. Also, let your doctor know if your child has or had any severe allergic reactions to any medicine. You should also consult your doctor if your child has ever been in a coma or has had brain or nervous system problems like seizures before scheduling a vaccination appointment. This information is important for the doctor to prepare a corresponding vaccination schedule.

Benefits of Pentashield Injection

Prevention of Tetanus
Diphtheria is a bacterial infection that causes pain and swelling in the throat. This may even cause difficulty in breathing. It might also damage the heart, kidneys, and nerves. Pentashield Vaccine protects against diphtheria. It is advisable to consult your doctor for complete information regarding vaccination schedules. After vaccination, most children develop antibodies sufficient enough to protect against diphtheria.
Prevention of Pertussis
Pertussis (often called whooping cough) is an infection of the airways that can occur at any age but mostly affects infants and young children. The infection causes uncontrollable coughing, making breathing difficult. Pentashield Vaccine offers the best protection against Pertussis. It is advisable to consult your doctor to gather complete information regarding vaccination schedules.
Prevention of Diphtheria
Tetanus, commonly called lockjaw, is a serious bacterial infection that affects the nervous system and causes muscles to become stiff and tighten. Pentashield Vaccine helps prevent tetanus infection. It helps the immune system to produce antibodies to fight against tetanus infection. Vaccination is the best way to protect your child against this life-threatening disease.
Prevention of Hepatitis B infection
Hepatitis B is a liver disease caused by contracting the hepatitis B virus. When Pentashield Vaccine is given to children, the immune system is stimulated thereby producing antibodies against this virus. These antibodies help provide protection against infection caused by the hepatitis B virus.
Prevention of Haemophilus influenzae Type b disease
Haemophilus Influenzae type b can cause serious illness, especially in children. These may include meningitis (infection of brain meninges), pneumonia, etc. It is spread mainly through contact with infected droplets (coughing or sneezing) or secretions from an infected person's nose and throat. Pentashield Vaccine provides long-term protection against this disease. It helps the immune system to produce antibodies to fight against the disease.

Side effects of Pentashield Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Pentashield
  • Loss of appetite
  • Irritation
  • Injection site reactions (pain, swelling, redness)
  • Skin rash
  • Fever

How to use Pentashield Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Pentashield Injection works

Pentashield Vaccine is a combination of five vaccines. It helps develop immunity by initiating a mild infection in the body. This type of infection does not cause illness but stimulates the body's immune system to produce antibodies (proteins) to protect against certain future infections.

Quick tips

  • Maintain a log of your child’s vaccination history. Be sure to ask for a personal record card or a printed copy of your child’s vaccinations. Whenever your child receives a vaccine, make sure your copy gets updated.
  • Vaccines can ensure the best protection when given at the right time. The Government of India has designed a National Immunization Schedule which suggests a timeline for vaccines to be given to infants, young children, and adolescents when they are vulnerable to specific vaccine-preventable diseases.
  • The duration of immunity varies with different diseases and different vaccines. Usually, the protection provided by vaccines decreases gradually over time. Neither natural infection nor vaccination may be able to provide lifelong immunity. Therefore, booster doses are sometimes recommended for certain vaccines, at specific ages.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Pentashield Vaccine. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Pentashield Vaccine is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

UNSAFE
Pentashield Vaccine is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

NOT RELEVANT
Not relevant, as Pentashield Vaccine is intended for use in hospitalized patients.
Kidney

Kidney

CAUTION
Pentashield Vaccine should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Pentashield Vaccine in patients with liver disease.

Frequently asked questions

Vaccinations protect your child against serious diseases by stimulating the immune system to create antibodies against certain bacteria or viruses.
Universal Immunisation Program is a vaccination program followed in India. Under this program, all infants and children are vaccinated to ensure prevention against many serious life-threatening diseases such as Diphtheria, Pertussis, Tetanus, Polio, Measles, severe forms of childhood tuberculosis, Hepatitis B, Haemophilus influenzae type b (Hib), and Diarrhea.
A fully immunized child has received all vaccines recommended in the National Immunization Schedule in required doses, at the appropriate age.
The duration of immunity varies with different diseases and different vaccines. Lifelong immunity is not always provided by either natural infection or vaccination. The protection provided by vaccines decreases gradually over time. Therefore, booster doses are sometimes recommended for certain vaccines to protect specific age groups.
Yes. Your child can still get vaccinated if he or she has a mild illness, a low-grade fever, or is taking antibiotics. Vaccination should be delayed only if your child's immunity is severely low or your child is suffering from any systemic illness that leads to low immunity. It would be best to talk with your child’s doctor if you have questions.
No. If your baby misses some doses, it is not necessary to start over. Your child’s doctor may suggest continuing the schedule where your child left off.
Usually, a record of all the vaccination which a child takes is maintained in many medical practices. So, remember to ask for a personal record card or a printed copy of your child’s vaccinations. However, it is still advised to keep records of your own at home. Always carry your copy of the record to all medical appointments. Whenever your child receives a vaccine, make sure your copy gets updated. Your child will benefit by having an accurate vaccination record throughout his or her life.
Herd immunity is a form of indirect protection from an infectious disease. It occurs when a sufficient percentage of a population becomes immune to an infection, either through vaccination or due to self-developed immunity against previous infections. Herd immunity helps reduce the likelihood of infection for individuals who lack immunity.
Vaccines have been used for decades and have proven to be effective. Like any other medicine, vaccines too cannot provide 100% results. The immunity produced by vaccines may vary from child to child. There may be children who may not be able to develop sufficient protective immunity against a disease-causing pathogen due to malnutrition, repeated episodes of diarrhea, or individual-specific immune response to a vaccine. These reasons may cause some children to suffer from vaccine-preventable diseases despite receiving the vaccination against them. However, in such cases, the disease is of less severity than in those who have never been vaccinated.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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