Orampho 50mg Injection

Liposomal Amphotericin B (50mg)

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Orampho 50mg Injection is an antifungal medicine used to treat severe fungal infections and visceral leishmaniasis (kala azar). It works by damaging the protective cell membrane of the fungus or parasite, which leads to their death. This helps clear the infection and improves recovery.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 27 Aug 2026 | 01:05 AM (IST)

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General Information

Contains

Liposomal Amphotericin B (50mg)

Marketer

Orchid Pharma Ltd

Storage

Store below 25°C

The content is shown in English

Product introduction

Orampho 50mg Injection is for external use only. You should use it in the dose and duration as advised by your doctor. The affected area should be clean and dry before application of the ointment. You must wash your hands thoroughly before and after applying this medicine. To avoid relapse, continue the use of this medicine even if symptoms begin to clear up.

Some of the common side effects include skin irritation at the site of application, fever, nausea and chills. Please consult your doctor if these side effects persist for a longer duration. Avoid direct contact of the cream or ointment with your eyes. In case of direct contact, wash your eyes with water and seek immediate medical attention.

Uses of Orampho Injection

Treatment of Severe fungal infections
Treatment of Leishmaniasis.

Benefits of Orampho Injection

Treatment of Severe fungal infections
Orampho 50mg Injection works by killing the fungi, which can cause serious infections. It is given by a doctor or nurse and should not be self-administered. It usually makes you feel better very quickly, but you should continue taking it as prescribed even when you feel better to make sure that all the fungi and yeast causing the infection are killed and do not become resistant.

Treatment of Leishmaniasis.
Orampho 50mg Injection is an antibiotic medicine and is used to treat Leishmaniasis, also called kala-azar, a serious or life-threatening illness that is spread by a parasite that enters the human body by the bite of infected sand flies. It kills the infection-causing parasite and stops further spread of the infection. This medicine is given by a doctor or nurse and should not be self-administered. Refrain from taking any other medicines along with this medicine (unless advised by the doctor) as they may affect the absorption of this medicine. Do not use this medicine to treat any other condition without consulting your doctor.

Side effects of Orampho Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Orampho

Decreased potassium level in blood
Nausea
Vomiting
Chills
Fever

How to use Orampho Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Orampho Injection works

Orampho 50mg Injection works by binding to ergosterol, an important component of the cell membrane of fungi and the parasite that causes leishmaniasis. This binding creates pores in the membrane, leading to leakage of cell contents and death of the organism. The liposomal formulation helps deliver the drug more selectively to infected tissues, reduces toxicity to healthy cells, and improves safety, especially for the kidneys, while maintaining strong antifungal and antiparasitic activity.

All substitutes for Orampho 50mg Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Orampho 50mg Injection is usually given slowly through a drip under the supervision of a doctor. Do not attempt to self-administer.
Stay hydrated before and after the injection, as it may help reduce kidney-related side effects.
Inform your doctor if you feel chills, fever, or muscle pain during or after receiving Orampho 50mg Injection.
Regular blood and kidney tests may be needed while on Orampho 50mg Injection therapy. Do not skip your follow-ups.
Tell your doctor beforehand if you are on any other medicine that affects the kidneys or have had past kidney issues.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Orampho 50mg Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Orampho 50mg Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Orampho 50mg Injection may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether Orampho 50mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

Orampho 50mg Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Orampho 50mg Injection in patients with liver disease.

Frequently asked questions

How is Orampho 50mg Injection administered?

Orampho 50mg Injection should be administered under the supervision of a trained healthcare professional or a doctor only and should not be self-administered. The dose will depend on the condition you are being treated for and will be decided by your doctor. Follow your doctor’s instructions carefully to get maximum benefit from Orampho 50mg Injection.

Is Orampho 50mg Injection fungistatic or fungicidal?

Orampho 50mg Injection is fungicidal in nature, which means it acts by killing the fungus.

What should I tell my doctor before starting treatment with Orampho 50mg Injection?

Before starting treatment with Orampho 50mg Injection, tell your doctor if you have any other health problems, like kidney or liver-related issues. This is because certain medical conditions may affect your treatment and you may even need dose modifications. Let your doctor know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Inform your doctor if you are planning a baby, if you are pregnant or breastfeeding.

Is Orampho 50mg Injection an antibiotic?

Yes, Orampho 50mg Injection is an antifungal antibiotic for the treatment of infections caused by fungi like fungal infections of one or more deep organs of the body, suspected fungal infections in patients with a raised temperature and neutropenia (reduced number of white blood cells and Visceral leishmaniasis (an infectious disease caused by a parasite).

Is Orampho 50mg Injection testing dose needed?

Yes, administration of Orampho 50mg Injection is associated with allergic reaction (severe and serious allergic), therefore it is recommended to administer a testing dose before starting the treatment to check for any sensitivity to the medicine.

Fact Box

Chemical Class

Aminoglycosides

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Action Class

Polyene Antifungals

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Phillips MA, Stanley SL Jr. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1424.
Bennett JE. Antifungal Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1571-75.
Robertson DB, Maibach HI. Dermatologic Pharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 1052.
Amphotericin B (liposome for injection) [FDA Label]. San Dimas, CA: Gilead Sciences, Inc.; 2008. [Accessed 21 Sept. 2020]. (online) Available from:
Amphotericin B [EMC SmPC]. London, UK: Gilead Sciences International Ltd.; 2019. [Accessed 21 Sept. 2020]. (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Orchid Pharma Ltd
Address: 15Th Floor, Tower 1, DLF Corporate Greens, Sector 74A, Gurugram, Haryana 122004

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Orampho 50mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Anti Infectives

Systemic Agents For Fungal Infections

Orampho 50mg Injection

Orampho 50mg Injection

Payment, Returns & Expiry

Payment

Free Return

Expiry after

Price Info

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Orampho Injection

Benefits of Orampho Injection

Side effects of Orampho Injection

How to use Orampho Injection

How Orampho Injection works

All substitutes for Orampho 50mg Injection

Phosome 50mg Injection

Abhope 50mg Injection

Sporotar 50mg Injection

Futicin Lyophillized Injection

Amphogard 50mg Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

How is Orampho 50mg Injection administered?

Is Orampho 50mg Injection fungistatic or fungicidal?

What should I tell my doctor before starting treatment with Orampho 50mg Injection?

Is Orampho 50mg Injection an antibiotic?

Is Orampho 50mg Injection testing dose needed?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests