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OLZEP D 10MG/20MG CAPSULE

Capsule
Rs.60for 1 strip(s) (10 capsules each)
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Composition FOR OLZEP D

Domperidone(10 mg),Omeprazole(20 mg)

food interaction for OLZEP D

alcohol interaction for OLZEP D

pregnancy interaction for OLZEP D

lactation interaction for OLZEP D

food
alcohol
pregnancy
lactation
There is no data available. Please consult doctor before consuming the drug.
Taking a large amount of alcohol can increase acidity and cause acid reflux in the food pipe causing heartburn. This would decrease the effect of this drug and can aggravate your underlying condition.
UNSAFE
Olzep d 10mg/20mg capsule may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
WEIGH RISKS VS. BENEFITS
Unknown. Human and animal studies are not available. Please consult your doctor.

SALT INFORMATION FOR OLZEP D

Domperidone(10 mg)

Uses

Domperidone is used in the treatment of vomiting

How it works

Domperidone indirectly stimulates the release of acetylcholine, a chemical messenger that can increase the motility of the intestine.

Common side effects

Dry mouth
Omeprazole(20 mg)

Uses

Omeprazole is used in the treatment of acidity, heartburn, intestinal ulcers and stomach ulcers.

How it works

Omeprazole lowers the acid production in the stomach.

Common side effects

Nausea, Abdominal pain, Diarrhoea, Constipation, Flatulence

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Expert advice FOR OLZEP D

  • Do not take Domperidone, if you are allergic to it or to any other content in the tablets.
  • Do not take the medicine, if you notice black, tarry stools (bowel motions) or blood in your stools, blockage or tear in the intestines or if you have a tumor of the pituitary gland (prolactinoma).
  • Do not take the drug, if you have moderate to severe liver disease, heart problems (irregular heart rate or heart failure) or abnormal salt levels in the blood.
  • Do not crush or chew the tablets, swallow them whole with a glass of water.
  • Do not take the drug if you intend to drive or operate heavy machinery as it may cause drowsiness.
  • Always take the tablets 15 to 30 minutes before meals and, if needed, before going to bed at night.
  • Consult your doctor, if you are above 60 years of age and taking domperidone for a long period of time.
  • Inform your doctor, if you are already taking medicines for fungal infections (ketoconazole) or antibiotics (e.g. gentamycin, erythromycin).

Frequently asked questions FOR OLZEP D

Domperidone

Q.

What is Domperidone used for?
Domperidone is used for the treatment of nausea (feeling sick) and vomiting as and when recommended by your doctor.

Q.

Is domperidone an over the counter drug?
Domperidone is not an over the counter (OTC) medicine and it is not advisable to take it without a prescription.

Q.

Does domperidone cause weight gain?
Weight gain has not been reported with the use of domperidone. If you notice any abnormal weight gain while using domperidone, please talk to your doctor.

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Q.

Does domperidone raise the blood pressure?
The increase in blood pressure is generally not seen with the use of domperidone. But if you experience an increase in blood pressure while using domperidone, please consult your doctor.

Q.

Can I take domperidone for morning sickness?
Domperidone is not indicated or recommended for treating morning sickness. Please consult your doctor if you plan to take any medicine for treating morning sickness.

Q.

How long can I take domperidone for breastfeeding?
Domperidone is not recommended if you are breastfeeding because it passes into breast milk and may affect your baby. Talk to your doctor as either you should not take this medicine or you should stop breastfeeding if you are asked to take it.

Q.

Can I take domperidone with antibiotics?
The use of domperidone with antibiotics like erythromycin, levofloxacin, moxifloxacin, spiramycin, and some antifungals is not recommended. Please consult your doctor before using any antibiotics with domperidone.

Q.

Can I take domperidone with lansoprazole?
Yes, domperidone can be taken with lansoprazole as no drug-drug interactions have been clinically seen when they are taken together. However, interactions may occur. Please consult your doctor before using the two medicines together.

Q.

Can I take domperidone with doxycycline?
Yes, domperidone can be taken with doxycycline. No drug--drug interactions have been reported. However, please consult your doctor before taking domperidone with doxycycline.

Q.

Can I take domperidone with omeprazole?
Yes, domperidone can be taken with omeprazole. No drug--drug interactions have been reported. However, interactions may occur. Please consult your doctor before using the two medicines together.

Q.

Can I take domperidone with citalopram?
The use of domperidone with citalopram is not recommended as it may increase the underlying heart problems like prolonged QTc interval. Please consult your doctor before taking the two medicines together.

Q.

Can I take domperidone with amitriptyline?
Yes, domperidone can be taken with amitriptyline. No drug--drug interactions have been reported. However, please consult your doctor before taking domperidone with amitriptyline.

Q.

Can I take domperidone with amoxicillin?
Yes, domperidone can be taken with amoxicillin. No drug-drug interactions have been reported. However, please consult your doctor before taking domperidone with amoxicillin.

Q.

Can I take domperidone with paracetamol?
Yes, domperidone can be taken with paracetamol. No drug--drug interactions have been reported. However, interactions may occur. Please consult your doctor.

Q.

Can I take domperidone without food?
It is recommended to take domperidone tablets 15 - 30 minutes before meals.

Q.

Can I take domperidone with tramadol?
Yes, domperidone can be taken with tramadol as no drug--drug interactions have been reported. However, please consult your doctor before taking domperidone with tramadol.

Q.

Is domperidone safe in pregnancy?
There is limited data on the use of domperidone in pregnant women. Therefore, domperidone should only be used during pregnancy when justified and recommended by the doctor.

Q.

Is domperidone safe?
Yes. Domperidone is safe if used at prescribed doses for the prescribed duration as advised by the physician/ doctor.

Q.

Is domperidone safe for babies?
Yes, domperidone is safe for use babies if used at prescribed doses and duration as advised by your doctor. Please consult your doctor before giving any medicine to your child.

Q.

Is domperidone used for motion sickness?
Domperidone is indicated for use in motion sickness. Please consult your doctor before using domperidone for motion sickness as it must be used in the dose and duration as advised by your doctor.

Q.

Is domperidone an antibiotic?
No, domperidone is not an antibiotic. Domperidone is an anti-emetic which is used to treat nausea (feeling sick) and vomiting (being sick).

Q.

Does domperidone cause drowsiness?
Drowsiness has been reported as one of the rare side effects with domperidone. Please talk to your doctor if you experience excessive drowsiness while taking domperidone.

Q.

Does domperidone increase milk secretion?
Yes, domperidone can increase milk secretion also known as galactorrhea. This is an uncommon side effect of domperidone. Talk to your doctor if you are experiencing this side effect while taking this medicine.

Q.

Does domperidone cause bloating (gas)?
Domperidone can cause some uncommon gastrointestinal side effects like regurgitation, appetite disorder, and heartburn, diarrhoea. However, bloating (gas) has not been reported as a side effect with domperidone.

Q.

Does domperidone cause hair loss?
Domperidone has not been reported to cause hair loss. Please consult your doctor in case you experience excessive hair loss while taking domperidone.

Q.

Does domperidone help constipation?
Domperidone is not indicated to treat constipation. Please talk to your doctor regarding its use.

Q.

Does domperidone cause heart problems?
Domperidone may be associated with an increased risk of heartbeat problem and heart attack. This risk may be more likely in those over 60 years old or taking higher doses. The risk also increases when domperidone is given together with other medicines. Please share your medical history with your doctor if you are prescribed domperidone.

Q.

Does domperidone cause constipation?
Yes, domperidone has been seen to cause constipation as a side effect.Consult your doctor if you experience excessive constipation while using domperidone.

Q.

Does domperidone relieve bloating (gas)?
Domperidone is an anti-emetic which is used to treat nausea (feeling sick) and vomiting (being sick). It is not indicated to treat bloating (gas). Please consult your doctor before using this medicine.

Omeprazole

Q.

What is omeprazole?
Omeprazole belongs to the group of medicines known as proton pump inhibitors (PPIs). This drug decreases the acid production in your stomach and is indicated for the treatment of conditions caused by excess acid secretion in the stomach.

Q.

What is omeprazole used for?
Omeprazole is used to treat and prevent duodenal ulcers, stomach ulcers and ulcers caused by the non-steroidal anti-inflammatory drug (NSAIDs; pain killers) and along with antibiotics for the treatment of stomach ulcers infected with a bacteria known as Helicobacter pylori. Omeprazole is also indicated for the treatment of reflux oesophagitis, symptomatic gastro-oesophageal reflux disease (GERD) and Zollinger-Ellison syndrome.

Q.

How does omeprazole work?
Proton (acid) pumps are found on the stomach mucosa and they are responsible for secreting acid in the stomach. Omeprazole works by blocking this gastric acid pump and this unique mechanism of action helps in decreasing the acid secretion in the stomach.

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Q.

Is omeprazole available without a prescription as an over the counter product?
Omeprazole is a prescription medicine and you can buy this drug by providing a doctor's prescription. Omeprazole is not available as an over the counter (OTC) product.

Q.

Who can take omeprazole?
Adults and children more than 1 year of age and more than 10 kg in weight can take omeprazole.

Q.

When and how should I take omeprazole?
Omeprazole capsules or tablets should be taken once a day in the morning preferably empty stomach at least half to one hour before breakfast. Swallow your medicine whole with minimum half a glass of water. Do not chew or crush the tablets or capsules.

Q.

What foods should be avoided while taking omeprazole?
You should preferably avoid taking foods that cause acidity and heartburn when you are taking omeprazole as these foods would aggravate your disease condition, for example: foods that are fried, prepared in butter or oil, fat rich foods, tomato-based foods and juices, caffeinated drinks like cola, tea, drinks from citrus fruits like lemon water or orange juice and alcohol-containing drinks.

Q.

How long does it take for omeprazole to start working?
Omeprazole may start to work on the first day of taking it, however, it may take 3 to 4 days to achieve its full effect. You may need to add another acid-lowering drug for relief in the initial few days.

Q.

For how long can omeprazole be taken?
Take omeprazole for as long as advised by your doctor. The duration of taking omeprazole would vary depending on your condition. You may be asked to take this drug for 2 weeks for healing of your duodenal ulcers, 4 weeks for stomach ulcers and 4 to 8 weeks for GERD symptoms and for ulcers caused by NSAIDs. Do not stop taking this medicine without talking to your doctor.

Q.

Where does omeprazole gets absorbed in the body?
Omeprazole gets absorbed in the small intestine.

Q.

How is omeprazole metabolised in the body?
Omeprazole is metabolized in the liver by the cytochrome P450 enzymes mainly CYP2C19. There could be an increase in the level of omeprazole in patients with underlying liver disease because of a decrease in its metabolism. However, the amount of drug does not increase if given once a day.

Q.

How long does omeprazole stay in the body?
Omeprazole stays in the body for almost 72 hours after stopping the medicine. Omeprazole is removed from the body through the urine.

Q.

What are the various conditions in which the use of omeprazole is contraindicated?
Use of omeprazole is contraindicated if you are allergic to this medicine or any other medicine belonging to the same class of drugs. Also, do not take omeprazole if you are already taking a medicine containing nelfinavir (used for the treatment of HIV infection).

Q.

Can omeprazole cause calcium deficiency and osteoporosis?
Omeprazole can cause calcium deficiency and hence an increased risk of bone fractures on long term use. Normally the acidic environment of the stomach helps in the release of ionized calcium from insoluble calcium salts, which is important for calcium absorption. As omeprazole causes a decrease in the gastric acid levels, so it can decrease calcium absorption and increase the risk of bone fractures.

Q.

Can omeprazole cause magnesium deficiency?
Omeprazole can cause magnesium deficiency in the blood. Low magnesium levels is a rare side effect seen in patients treated with omeprazole for at least three months and in most cases after a year of therapy. The patient may have symptoms like tetany, arrhythmias, and seizures and may need to stop this medicine and take magnesium from outside. Magnesium levels should be tested at regular intervals in the patients taking omeprazole for a long duration.

Q.

Does omeprazole cause iron deficiency?
Use of omeprazole can cause iron deficiency and a decrease in hemoglobin levels as it decreases the acidic environment of the stomach needed for the absorption of iron. However, there are no recommendations on the regular monitoring of iron levels or taking iron supplements when the patient is taking omeprazole.

Q.

Does omeprazole cause vitamin deficiencies?
Omeprazole may cause vitamin B12 and vitamin C deficiency. When taken orally, vitamin B12 requires an acidic environment for its absorption from the stomach while omeprazole causes a decrease the gastric acid secretion. You may need to take vitamin B12 supplements from outside. The clinical significance of the decrease in vitamin C levels is not known, so vitamin C supplementation is not recommended.

Q.

Can omeprazole cause lactose intolerance?
Lactose intolerance has been reported with the use of omeprazole in some patients. Many omeprazole preparations contain lactose as an ingredient. This is a digestive problem in which the patient cannot digest lactose, a type of sugar mainly found in milk and dairy products. The patient may complain of symptoms like flatulence (gas), diarrhea, bloating, stomach pain and feeling of being sick (nausea). Read the ingredients mentioned on the pack before taking the medicine.

Q.

Does omeprazole contain gelatin?
Omeprazole does not contain gelatin as one of its constituent. However, in the capsule dosage form of omeprazole, the outer capsule that contains the medicine is made up of gelatin.

Q.

Can I take omeprazole with alcohol?
Omeprazole can be taken with alcohol as no harmful effects have been reported. However, alcohol intake can cause higher acid secretion, hence decreasing the acid lowering effect of omeprazole. Also, omeprazole can make some people feel dizzy or sleepy, adding to the sedative effects of alcohol and they may find it difficult to drive or operate a machine.

Q.

Can I take omeprazole during pregnancy?
Omeprazole may be unsafe to take during pregnancy. There is limited data available from humans, however, animal studies have shown harmful effects of omeprazole use on the foetus (unborn baby). Talk to your doctor if you are pregnant or planning to have a baby before taking omeprazole as your doctor would be able to advise you better on the basis of your underlying health condition.

Q.

Can I take omeprazole during lactation?
Omeprazole passes (excreted) into the breast milk but is not likely to cause any harmful effects to the child when taken in doses as advised. Your doctor can help you decide whether you should take omeprazole during breastfeeding (lactation) or not.

Q.

What if I miss my dose of omeprazole?
If you miss a dose of omeprazole, take it as soon as you remember and the next dose as scheduled. However, if it is almost the time for your next dose, skip the missed dose and take your next dose and then follow the regular schedule. Do not take double the dose.

Q.

Can omeprazole affect my driving?
Omeprazole is not likely to affect your ability to drive or use machines. However, omeprazole can cause dizziness and visual disturbances, so, you may need to be careful while driving or operating any machinery if you experience these symptoms.

Q.

How do I store omeprazole?
Store omeprazole below 25°C (between 15°C and 30°C). Keep in a cool and dark place in the original pack.

Q.

Does omeprazole have an expiry date?
Yes, omeprazole does expire. Please check the expiry date written on the pack and it refers to the last day of that month. Do not use omeprazole after the expiry date.

Q.

Is omeprazole a narcotic substance?
Omeprazole is a not a narcotic substance and has not been reported to have any abuse potential. Omeprazole does not get you high and does not cause any addiction as no withdrawal symptoms have been reported when you stop taking this drug.

Q.

Is omeprazole a controlled substance?
Omeprazole is not a controlled substance. It is available when prescribed by a doctor.

Q.

What are the side effects of using omeprazole?
The most common side effects seen with the use of omeprazole are a headache, diarrhea, constipation, flatulence (gas), bloating, stomach pain (abdominal pain), feeling sick (nausea) or being sick (vomiting), non-cancerous (benign) growths in the stomach. A few uncommon side effects are skin rash, lumpy rash (hives), itchy skin, generally feeling unwell and lacking energy, swelling of the feet and ankles, disturbed sleep (insomnia), dizziness, tingling feelings such as “pins and needles”, feeling sleepy, spinning feeling (vertigo), changes in liver function tests.

Q.

What are the rare side effects of omeprazole?
Rare side effects seen with the use of omeprazole are decrease in white cells or platelets causing weakness, bruising or infections more common. Allergic reactions with swelling of the lips, tongue and throat, fever, wheezing, low levels of sodium in the blood, agitation, confusion or depression, taste changes, eyesight problems like blurred vision, wheezing, shortness of breath (bronchospasm), dry mouth, thrush, liver problems like jaundice, hair loss (alopecia), skin rash on exposure to sunshine, joint pains (arthralgia) or muscle pains (myalgia), severe kidney problems (interstitial nephritis), increased sweating, inflammation of the gut causing diarrhoea

Q.

Does omeprazole cause hepatitis B and can a patient of hepatitis take omeprazole?
Omeprazole can rarely cause hepatitis with or without jaundice and very rarely it can lead to hepatic failure and encephalopathy in patients with the underlying liver disease. Omeprazole does not cause hepatitis B or any other viral hepatitis. However, there are studies showing an increased occurrence of hepatic encephalopathy in hepatitis B patients using PPIs. These medicines should be used with caution in patients with the underlying liver disease.

Q.

Does omeprazole use increase the risk of clostridium difficile infection?
Use of proton pump inhibitors (PPIs) like omeprazole may be associated with an increased risk of Clostridium difficile–associated diarrhea (CDAD) as reported in few studies and informed by the US FDA as well. A possibility of CDAD can be there in patients taking PPIs and developed diarrhea that does not improve.

Q.

Can I take omeprazole along with oral contraceptive pills (birth control pills)?
Omeprazole can be safely taken with oral contraceptive pills (birth control). They do not affect each other's action and no harmful effects have been seen when they are used together.

Q.

Can I take omeprazole with Vitamin E?
Omeprazole can be taken with vitamin E. The combinations seems to have a beneficial effect in terms of better maintenance of moderate to severe esophagitis. However, there are not many studies or reports on this subject. Talk to your doctor for more information on this.

Q.

Can omeprazole cause subacute cutaneous lupus erythematosus?
Omeprazole has been reported to cause subacute cutaneous lupus erythematosus in many studies. Common signs and symptoms of this disease include painful joints, tiredness, weakness, rash, fever, anemia, mouth ulcers, hair loss, and many others and these may get aggravated again and again. Talk to your doctor if you experience these side effects as you may need to discontinue this medicine.

Q.

Does omeprazole increase chromogranin levels?
Use of proton pump inhibitors like omeprazole has been seen to be associated with an increase in chromogranin levels. This increase in chromogranin levels can be due to the effect of these drugs on enterochromaffin cells and this could also falsely increase the levels in patients with neuroendocrine tumours.

Q.

Does omeprazole cause dementia?
Use of proton pump inhibitors like omeprazole has been recently linked with the development of dementia in elderly patients. As this risk of developing dementia is not confirmed, talk to your doctor for more information on this effect.

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Content on this page was last updated on 08 March, 2017, by Dr. Varun Gupta (MD Pharmacology)