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Domperidone + Omeprazole

Written By Dr. Lipika KhuranaReviewed By Dr. Rajeev Sharma
Last updated 25 Nov 2025 | 09:37 AM (UTC)

Domperidone + Omeprazole Uses

Domperidone+Omeprazole is used in the treatment of gastroesophageal reflux disease (acid reflux) and peptic ulcer disease.

Available generics for Domperidone + Omeprazole

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How Domperidone + Omeprazole works

Domperidone + Omeprazole is a combination of two medicines: Domperidone and Omeprazole. Domperidone is a prokinetic which works on the upper digestive tract to increase the movement of the stomach and intestines, allowing the food to move more easily through the stomach. Omeprazole is a proton pump inhibitor (PPI) which works by reducing the amount of acid in the stomach which helps in the relief of acid-related indigestion and heartburn.

Common side effects of Domperidone + Omeprazole

Diarrhea, Headache, Flatulence, Nausea, Vomiting, Constipation, Abdominal pain, Fundic gland polyps
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Medicine brands for Domperidone + Omeprazole

Gaspaz DS
Biological E Ltd
₹46 to ₹69
2 variant(s)
Gaspaz DS
Ocid-D
Zydus Cadila
₹198 to ₹273
2 variant(s)
Ocid-D
Domstal O
Torrent Pharmaceuticals Ltd
₹139 to ₹172
2 variant(s)
Domstal O
Omidom
Mankind Pharma Ltd
₹52 to ₹64
3 variant(s)
Omidom
Ranidom NF
Mankind Pharma Ltd
₹83 to ₹92
2 variant(s)
Ranidom NF
Domped OZ
Medispan Ltd
₹70 to ₹70
1 variant(s)
Domped OZ
Omiflux
Micro Labs Ltd
₹148 to ₹148
1 variant(s)
Omiflux
Omlink-D
Lincoln Pharmaceuticals Ltd
₹33 to ₹33
1 variant(s)
Omlink-D
Omerd
Blue Cross Laboratories Ltd
₹40 to ₹40
1 variant(s)
Omerd
Oskar DSR
Mankind Pharma Ltd
₹96 to ₹96
1 variant(s)
Oskar DSR

Expert advice for Domperidone + Omeprazole

  • You have been prescribed Domperidone + Omeprazole for the treatment of acidity and heartburn.
  • Take it one hour before the meal, preferably in the morning.
  • It is a well-tolerated medicine and provides relief for a long time.
  • Inform your doctor if you get watery diarrhea, fever or stomach pain that does not go away.
  • Inform your doctor if you do not feel better after taking it for 14 days as you may be suffering from some other problem that needs attention.
  • Long-term use can cause weak bones and deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or their supplements as prescribed by your doctor.

Frequently asked questions for Domperidone + Omeprazole

Yes, Domperidone+Omeprazole is safe for most of the patients. However, in some patients it may cause common side effects like diarrhea, stomach pain, flatulence, dryness in the mouth, dizziness, headache and other uncommon and rare side effects. Inform your doctor if you experience any persistent problem while taking this medicine.
The use of Domperidone+Omeprazole is considered to be harmful in patients with a known hypersensitivity to omeprazole or domperidone or any other inactive ingredients present in the medicine. Cautious use is advised in patients with underlying kidney or liver disease.
It is best to take the medicine daily before breakfast or on an empty stomach.
Yes, the use of Domperidone+Omeprazole can cause an increased risk of irregular heartbeat (serious arrhythmias). These are serious side effects but the chances that it may happen is very low. The risk may be slightly higher in those who are more than 60 years of age.
Yes, the use of Domperidone+Omeprazole can cause dry mouth. Dryness of mouth occurs due to Domperidone, which is present in this combination. If you experience dry mouth, drink plenty of water. Take regular sips of water during the day and keep some water on your bedside at night. Cut down the intake of alcohol and avoid smoking. If you have dry mouth, try to use alcohol-free mouthwash as its use increases the risk of tooth decay.
Keep this medicine in the container or pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.