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Nurosig Plus Tablet PR 1
Nurosig Plus Tablet PR 2
Nurosig Plus Tablet PR 3
Nurosig Plus Tablet PR 4
Nurosig Plus Tablet PR 5
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Nurosig Plus Tablet PR is a prescription medicine used for the treatment of neuropathic pain. It decreases pain by modulating the calcium channel activity of the nerve cells. This medicine also protects nerve fibers and heals damaged nerve cells.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 07 Sep 2026 | 01:01 AM (IST)
₹131 MRP ₹14510% off 
(Inclusive of applicable taxes)
Gurgaon
 
 
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General Information

Contains

Methylcobalamin (1500mcg)+ Pregabalin (75mg)

Marketer

Signova Pharma (P) Ltd

Storage

Store below 25°C
The content is shown in English
Nurosig Plus Tablet PR 1
Nurosig Plus Tablet PR 2
Nurosig Plus Tablet PR 3
Nurosig Plus Tablet PR 4
Nurosig Plus Tablet PR 5

Product introduction

Nurosig Plus Tablet PR may be taken with or without food, preferably at bedtime. It is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration advised by your doctor. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better. This medication must not be stopped suddenly without talking to the doctor.


Some common side effects of this medicine include nausea, vomiting, diarrhea, constipation, blurred vision, dizziness, and sleepiness. Do not drive or do anything that requires mental focus until you know how this medicine affects you. The side effects are mild and usually improve with time. It may also cause weight gain in some people. Exercise regularly and have a balanced diet to keep your weight in check. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts.


Your doctor should also know about all other medicines you are taking, as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding to make sure it is safe for you and the developing baby.

Uses of Nurosig Plus Tablet PR

Benefits of Nurosig Plus Tablet PR

Treatment of Neuropathic pain
Nurosig Plus Tablet PR is a combination of medicines used to treat long-lasting (chronic) pain caused by nerve damage due to diabetes, shingles or spinal cord injury. It reduces pain and its associated symptoms such as mood changes, sleep problems, and tiredness. Pregabalin, an active ingredient of this medicine, is thought to work by interfering with pain signals that travel through the damaged nerves and the brain. It also contains nutritional supplements that improve nerve conduction. Taking Nurosig Plus Tablet PR regularly will improve your physical and social functioning and overall quality of life.

Side effects of Nurosig Plus Tablet PR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Nurosig Plus
  • Headache
  • Sleepiness
  • Dizziness
  • Abnormality of voluntary movements
  • Blurred vision
  • Constipation
  • Edema (swelling)
  • Weight gain
  • Weakness
  • Dryness in mouth
  • Abnormal thoughts

How to use Nurosig Plus Tablet PR

Use it as advised by your doctor or check the label for directions before use. Nurosig Plus Tablet PR may be taken with or without food.

How Nurosig Plus Tablet PR works

Nurosig Plus Tablet PR is a combination of two medicines: Methylcobalamin and Pregabalin. Methylcobalamin is a form of vitamin B, which helps in the production of myelin, a substance that protects nerve fibers and rejuvenates damaged nerve cells. Pregabalin is an alpha-2 delta ligand that decreases pain by modulating the calcium channel activity of the nerve cells. Together, they relieve neuropathic pain (pain from damaged nerves).

Quick tips

  • Nurosig Plus Tablet PR may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
  • To lower the chances of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • Avoid consuming alcohol when taking Nurosig Plus Tablet PR, as it may cause excessive sleepiness.
  • Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
  • Do not stop taking the medication suddenly without talking to your doctor.
  • Nurosig Plus Tablet PR may cause weight gain. Exercise regularly and eat a balanced diet to manage it.

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Nurosig Plus Tablet PR may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Nurosig Plus Tablet PR during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Nurosig Plus Tablet PR may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Nurosig Plus Tablet PR may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Nurosig Plus Tablet PR should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Nurosig Plus Tablet PR should be used with caution in patients with liver disease. Dose adjustment may be needed.
All

Frequently asked questions

Nurosig Plus Tablet PR is a combination of two medicines: pregabalin and methylcobalamin. It is used for the treatment of nerve pain (neuropathic pain). It calms the damaged or overactive nerves by acting on the brain, thereby decreasing the pain sensation. It also helps in the regeneration of damaged nerves in the body.
No, you should not stop taking Nurosig Plus Tablet PR even if your pain is relieved. Continue to take it as advised by your doctor. If you suddenly stop taking Nurosig Plus Tablet PR, you may experience withdrawal symptoms such as anxiety, sleeping difficulties, nausea, pain, and sweating. You may need to gradually taper the use of Nurosig Plus Tablet PR before you stop the medication completely.
Nurosig Plus Tablet PR can make you feel hungry, which might make you eat more, thereby increasing your chances of putting on weight. However, preventing weight gain is easier than losing the increased weight. Try to eat a healthy balanced diet without increasing your portion sizes (per-meal intake). Do not eat food items that contain a lot of calories, such as soft drinks, oily food, chips, cakes, biscuits, and sweets. If you feel hungry between meals, avoid eating junk food and eat fruits, vegetables, and low-calorie foods. Regular exercise will help prevent weight gain. If you maintain good eating habits and exercise regularly, you might not gain any weight.
Yes, Nurosig Plus Tablet PR may make you feel drowsy, or you may suddenly fall asleep during your daily activities. Sometimes, you might not even feel drowsy or have any other warning signs before you suddenly fall asleep. Avoid driving a car, operating machinery, working at heights, or participating in potentially dangerous activities at the beginning of your treatment until you know how the medicine affects you. Inform your doctor if you experience such episodes while you are taking this medicine.
If you forget to take the scheduled dose of Nurosig Plus Tablet PR, and it is almost time for your next dose, skip the dose you missed and take your next dose at the scheduled time. Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally. Do not take a double dose to make up for the dose you missed because this may increase the risk of unwanted side effects. If you are not sure what to do, consult your doctor about how to manage a situation like this.
No, taking a higher-than-recommended dose may not be more effective; rather, it may increase the chances of having some serious side effects and toxicity. If you experience increased severity of your symptoms that are not relieved by the recommended doses, please consult your doctor for re-evaluation.
No, do not drink alcohol while taking Nurosig Plus Tablet PR. Drinking alcohol can increase the severity of drowsiness or sleepiness caused by Nurosig Plus Tablet PR.
You may need to see your doctor regularly if you have started to take Nurosig Plus Tablet PR. However, you must consult your doctor if the advised dosage of Nurosig Plus Tablet PR does not improve your symptoms or if you continue experiencing some unwanted side effects that affect your routine activities.
Keep your tablets in the pack until it is time to take them. Store them in a cool, dry place. Store them out of sight and reach of children. Unused medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.
Nurosig Plus Tablet PR is a combination of two medicines: Pregabalin and Methylcobalamin. This medicine is useful in the treatment of nerve pain (neuropathic pain). It calms the damaged or overactive nerves by acting on the brain, thereby decreasing the pain sensation. It also helps in the regeneration of damaged nerves in the body.
No, you should not stop taking Nurosig Plus Tablet PR even if your pain is relieved. Continue to take it as advised by your doctor. If you suddenly stop taking Nurosig Plus Tablet PR, you may experience withdrawal symptoms such as anxiety, sleeping difficulties, nausea, pain and sweating. You may need to gradually taper the use of Nurosig Plus Tablet PR before you stop the medication completely.
Nurosig Plus Tablet PR can make you feel hungry which might make you eat more, thereby increasing your chances of putting on weight. However, preventing weight gain is easier than losing the increased weight. Try to eat a healthy balanced diet without increasing your portion sizes (per-meal intake). Do not eat food items that contain a lot of calories, such as soft drinks, oily food, chips, cakes, biscuits, and sweets. If you feel hungry between meals, avoid eating junk food and eat fruits, vegetables and low-calorie foods. Regular exercise will help prevent weight gain. If you maintain good eating habits and exercise regularly, you might not gain any weight.
Yes, Nurosig Plus Tablet PR may make you feel drowsy or you may suddenly fall asleep during your daily activities. Sometimes, you might not even feel drowsy or have any other warning signs before you suddenly fall asleep. Avoid driving a car, operating machinery, working at heights or participating in potentially dangerous activities at the beginning of your treatment until you know how the medicine affects you. Inform your doctor if you experience such episodes while you are taking this medicine.
Serious side effects caused because of the use of Nurosig Plus Tablet PR are uncommon and rare. However, it may cause serious side effects like allergic reaction, suicidal thoughts or swelling of limbs (hands, legs or feet). Stop taking Nurosig Plus Tablet PR and contact your doctor if you have any signs of these serious side effects. Signs of an allergic reaction include swelling of your face, mouth, lips, gums, tongue and neck. Allergic reactions can also lead to trouble in breathing, skin rash, hives (raised bumps) or blisters. Pay attention to any changes, especially sudden changes in mood, behaviors, thoughts or feelings, or if you have suicidal thoughts.
An initial benefit with Nurosig Plus Tablet PR may be seen after 2 weeks of treatment. However, it may take around 2-3 months or more (in some patients) to see the full benefits.
If you forget to take the scheduled dose of Nurosig Plus Tablet PR and it is almost time for your next dose, skip the dose you missed and take your next dose at the scheduled time. Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally. Do not take a double dose to make up for the dose you missed because this may increase the risk of unwanted side effects. If you are not sure what to do, consult your doctor about how to manage a situation like this.
No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having some serious side effects and toxicity. If you experience increased severity of your symptoms that are not relieved by the recommended doses, please consult your doctor for re-evaluation.
No, do not drink alcohol while taking Nurosig Plus Tablet PR. Drinking alcohol can increase the severity of drowsiness or sleepiness caused by Nurosig Plus Tablet PR.
You may need to see your doctor regularly if you have started to take Nurosig Plus Tablet PR. However, you must consult your doctor if the advised dosage of Nurosig Plus Tablet PR does not improve your symptoms or you continue experiencing some unwanted side effects that affect your routine activities.
Keep your tablets in the pack until it is time to take them. Store them in a cool dry place. Store them out of sight and reach of children. Unused medications should be disposed of in special ways to ensure that pets, children and other people cannot consume them.

Fact Box

Habit Forming

No

Therapeutic Class

NEURO CNS

References

  1. Pregabalin [Prescribing Information]. Vega Baja, Puerto Rico: Pfizer Pharmaceuticals LLC; 2009. [Accessed 22 Apr. 2019] (online) Available from:
  2. Pregabalin [Prescribing Information]. New York, NY: Pfizer; 2004 [revised Jun 2011]. [Accessed 22 Apr. 2019] (online) Available from:
  3. Methylcobalamin and pregabalin [Patient Information]. Pune, Maharashtra: Epion Pharmaceuticals Pvt. Ltd.; [Accessed 14 Apr. 2025] (online) Available from:
  4. Methylcobalamin and pregabalin [Patient Information]. Ahmedabad, Gujarat: West Coast Pharmaceutical Works Ltd.; [Accessed 14 Apr. 2025] (online) Available from:
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Marketer details

Name: Signova Pharma (P) Ltd
Address: SCF - 36, Ground Floor, M.Market, Manimajra, Chandigarh.

Vendor Details

Country of origin: India

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