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NICLONZ 4 MG PASTILLES

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MRP: Rs. 75 for 1 box(s) (10 pastilles each)
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Composition for NICLONZ

Nicotine(4 mg)

food interaction for NICLONZ

alcohol interaction for NICLONZ

pregnancy interaction for NICLONZ

lactation interaction for NICLONZ

food
alcohol
pregnancy
lactation
No interaction found
No interaction found
Niclonz 4 mg pastilles is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
WEIGH RISKS VS. BENEFITS
Niclonz 4 mg pastilles is probably unsafe to use during breastfeeding. Please consult your doctor.
UNSAFE

SALT INFORMATION for NICLONZ

Nicotine(4 mg)

Uses

Niclonz 4 mg pastilles is used in smoking addiction.

How it works

Niclonz 4 mg pastilles is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. These are ionotropic receptors composed up of five homomeric or heteromeric subunits. In the brain, Niclonz 4 mg pastilles binds to nicotinic acetylcholine receptors on dopaminergic neurons in the cortico-limbic pathways. This causes the channel to open and allow conductance of multiple cations including sodium, calcium, and potassium. This leads to depolarization, which activates voltage-gated calcium channels and allows more calcium to enter the axon terminal. Calcium stimulates vesicle trafficking towards the plasma membrane and the release of dopamine into the synapse. Dopamine binding to its receptors is responsible the euphoric and addictive properties of Niclonz 4 mg pastilles. Niclonz 4 mg pastilles also binds to nicotinic acetylcholine receptors on the chromaffin cells in the adrenal medulla. Binding opens the ion channel allowing influx of sodium, causing depolarization of the cell, which activates voltage-gated calcium channels. Calcium triggers the release of epinephrine from intracellular vesicles into the bloodstream, which causes vasoconstriction, increased blood pressure, increased heart rate, and increased blood sugar.

Common side effects

Pale colored skin, Palpitations, Paresthesia (tingling or pricking sensation), Epileptic convulsion, Fainting, Increased glucose level in blood, Increased lactate level in blood, Increased depth of breathing, Decreased insulin level in blood, Increased sweating, Respiratory arrest, Tremor

SUBSTITUTES for NICLONZ

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Content on this page was last updated on 24 October, 2016, by Dr. Varun Gupta (MD Pharmacology)