NI Plus Tablet

Nimesulide (100mg)+ Paracetamol (500mg)

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NI Plus Tablet is a combination medicine that helps in relieving pain. It is used to relieve pain and inflammation in conditions like rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It is also used to relieve muscle pain, back pain, toothache, or pain in the ear and throat.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 06 Aug 2026 | 01:06 AM (IST)

₹35.4 MRP ₹39.3810% off

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General Information

Contains

Nimesulide (100mg)+ Paracetamol (500mg)

Marketer

Baksun Healthcare Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

NI Plus Tablet should be taken with food. This will prevent you from getting an upset stomach. The dose will depend on what you are taking it for and how well it helps your symptoms. You should take it as advised by your doctor. Do not take more or use it for a longer duration than recommended by the doctor.

The most common side effects of this medicine include nausea, vomiting, diarrhea, and increased liver enzymes. If any of these side effects bother you or get worse, you should speak to your doctor. Your doctor may be able to suggest ways of preventing or reducing the side effects.

Before taking it, you should let your doctor know if you have a history of ulcers or bleeding in your stomach, high blood pressure, or any trouble with your heart, kidneys, or liver. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.

Pregnant or breastfeeding women should consult their doctor before starting treatment. You should also avoid drinking alcohol while you are taking this medicine, as alcohol can cause excessive drowsiness.

Uses of NI Plus Tablet

Pain relief : NI Plus Tablet helps relieve pain in conditions such as headache, body ache, muscle pain, toothache, menstrual cramps, and minor injuries.

Benefits of NI Plus Tablet

Pain relief
Pain and inflammation can occur due to injury or conditions affecting the joints and muscles. NI Plus Tablet helps reduce pain, inflammation, and swelling. This helps relieve discomfort in conditions such as arthritis, muscle pain, and other short-term painful conditions. It improves movement and supports better daily functioning.

Side effects of NI Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of NI Plus

Nausea
Vomiting
Diarrhea
Increased liver enzymes
Headache
Dizziness
Stomach discomfort
Abnormal liver function

How to use NI Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. NI Plus Tablet should be taken with or after food.

How NI Plus Tablet works

NI Plus Tablet is a combination of two medicines: Nimesulide and Paracetamol. It works by blocking the release of certain chemical messengers that cause fever, pain, and inflammation (redness and swelling).

All substitutes for NI Plus Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Take NI Plus Tablet with food to reduce the risk of stomach irritation.
NI Plus Tablet may cause dizziness or sleepiness, so avoid driving or operating machinery until you know how it affects you.
Avoid alcohol while taking NI Plus Tablet, as it may increase drowsiness and the risk of liver problems.
Do not take NI Plus Tablet with other medicines containing paracetamol unless advised by your doctor.
Avoid taking NI Plus Tablet with other NSAIDs unless your doctor recommends it.
Use NI Plus Tablet only for the duration prescribed, as prolonged or excessive use may increase the risk of liver-related side effects.
Stop taking NI Plus Tablet and seek medical attention if you notice yellowing of the skin or eyes, which may indicate liver problems.
Watch for warning signs such as severe stomach pain or black/tarry stools, and seek medical attention if they occur.
Inform your doctor if you have a history of liver disease before taking NI Plus Tablet.
Stop using NI Plus Tablet and consult your doctor if rash, swelling, or signs of an allergic reaction occur.
Consult your doctor if pain or fever persists despite taking NI Plus Tablet.
Do not increase the dose or extend the duration of NI Plus Tablet without medical advice.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking NI Plus Tablet.

Pregnancy

UNSAFE

NI Plus Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

CONSULT YOUR DOCTOR

NI Plus Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

NI Plus Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of NI Plus Tablet in patients with kidney disease. Please consult your doctor.
Use of NI Plus Tablet is not recommended in patients with severe kidney disease.

Liver

UNSAFE

NI Plus Tablet is unsafe to use in patients with liver disease and should be avoided.

Frequently asked questions

What is NI Plus Tablet, and what is it used for?

NI Plus Tablet is a medicine used for short-term relief of pain, fever, and inflammation. Your doctor may prescribe it for conditions such as a toothache, body pain, joint pain, muscle pain, or pain related to injuries. It works by reducing pain signals and inflammation in the body, which helps relieve discomfort. However, NI Plus Tablet only helps control symptoms and does not treat the underlying cause of pain. Because it contains strong pain-relieving ingredients, it should be taken only under a doctor’s supervision and not used for long periods without medical advice.

Can I stop taking NI Plus Tablet when my pain is relieved?

NI Plus Tablet is usually prescribed for short-term pain relief. If your pain improves, you may be able to stop taking it. However, if your doctor has advised you to take it for a specific period or for a particular condition, you should continue it as directed. Always follow your doctor’s instructions before stopping the medicine.

What are the side effects of NI Plus Tablet?

NI Plus Tablet may cause side effects such as nausea, vomiting, stomach discomfort, dizziness, or tiredness in some people. Taking the medicine with food or milk may help reduce stomach upset. Most people do not feel sleepy while taking it, but some may feel light-headed or weak. Drinking enough fluids may help if you feel unwell. Consult your doctor if these symptoms persist or if you experience severe vomiting, dizziness, or unusual discomfort.

Who should not take NI Plus Tablet?

NI Plus Tablet should not be taken by people who are allergic to this medicine or to other similar pain relievers known as NSAIDs. It is also not recommended for individuals with stomach ulcers or bleeding, severe liver disease, kidney problems, heart failure, or uncontrolled high blood pressure unless advised by a doctor. The medicine may carry a risk of liver injury, especially with repeated use or when combined with alcohol. Always inform your doctor about your medical history before taking NI Plus Tablet.

Can I take NI Plus Tablet with vitamin B-complex?

Yes, NI Plus Tablet can usually be taken with vitamin B-complex supplements. While NI Plus Tablet helps relieve pain, vitamin B-complex may help correct vitamin deficiencies that sometimes contribute to symptoms such as nerve pain or fatigue. However, it is always best to consult your doctor before combining medicines or supplements.

Does NI Plus Tablet help relieve stomach pain?

NI Plus Tablet should not be taken for stomach pain without consulting a doctor. The medicine may increase the risk of stomach irritation and could worsen certain underlying stomach conditions, such as gastritis or ulcers. If you have persistent stomach pain, seek medical advice rather than self-medicating.

Can NI Plus Tablet damage the liver?

Yes, NI Plus Tablet may affect the liver if it is taken in higher-than-recommended doses or used for a long time. The risk increases if you drink alcohol, already have liver disease, or take other medicines that contain similar ingredients. Stop taking the medicine and seek medical help if you notice symptoms such as yellowing of the skin or eyes, dark urine, severe tiredness, or unusual weakness.

Can NI Plus Tablet be used during pregnancy?

NI Plus Tablet should generally be avoided during pregnancy unless a doctor specifically advises it. Certain anti-inflammatory pain medicines can affect pregnancy and the baby, particularly during the later stages. If you experience pain during pregnancy, consult your doctor so that a safer treatment option can be recommended.

What should I avoid while taking NI Plus Tablet?

While taking NI Plus Tablet, avoid drinking alcohol because it increases the risk of liver damage. Do not take other medicines that contain paracetamol or similar pain-relieving ingredients at the same time unless advised by your doctor. If you are prone to acidity, avoid taking the medicine on an empty stomach and try to eat light meals while using it. Staying well hydrated may also help reduce discomfort.

Can I take NI Plus Tablet for many days for chronic pain?

NI Plus Tablet is not intended for long-term or daily use for chronic pain unless your doctor closely supervises the treatment. Repeated or prolonged use can increase the risk of liver problems and may hide the underlying cause of the pain. Chronic pain conditions often require proper evaluation and a long-term treatment plan. Consult your doctor for safer options rather than using NI Plus Tablet regularly for extended periods.

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Baksun Healthcare Pvt Ltd
Address: 147/19+18 D KARVE ROADKOTHRUD PUNE MH 411029 IN , - , .

Vendor Details

Country of origin: India

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Pain Analgesics

Anti Rheumatics Non Steroidal Systemic

NI Plus Tablet

NI Plus Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of NI Plus Tablet

Benefits of NI Plus Tablet

Side effects of NI Plus Tablet

How to use NI Plus Tablet

How NI Plus Tablet works

All substitutes for NI Plus Tablet

Dolide Cold 100 mg/500 mg Tablet

Nimol Plus Tablet

Algiril 100 mg/500 mg Tablet

Nimisun Plus Tablet

Nimulet Plus Kid 100 mg/500 mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is NI Plus Tablet, and what is it used for?

Can I stop taking NI Plus Tablet when my pain is relieved?

What are the side effects of NI Plus Tablet?

Who should not take NI Plus Tablet?

Can I take NI Plus Tablet with vitamin B-complex?

Does NI Plus Tablet help relieve stomach pain?

Can NI Plus Tablet damage the liver?

Can NI Plus Tablet be used during pregnancy?

What should I avoid while taking NI Plus Tablet?

Can I take NI Plus Tablet for many days for chronic pain?

Fact Box

Habit Forming

Therapeutic Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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