Overview
Uses and benefits
Side effects
How to use
How drug works
Safety advice
Missed dose
All substitutes
Quick tips
Fact box
Patient concerns

Author Details

Written By

Dr. Nitika Makhija

MDS, BDS

Reviewed By

Dr. Rajeev Sharma

MBA, MBBS

Last updated

17 Apr 2025 | 03:08 PM (IST)

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Nexola Plus Tablet

Prescription Required

Marketer

Lifecare Neuro Products Ltd

SALT COMPOSITION

Fluoxetine (20mg) + Olanzapine (5mg)

Storage

Store below 30°C

Click here to view all substitutes

Product introduction

Nexola Plus Tablet is a prescription medicine used in the treatment of depression associated with bipolar disorder. It works by increasing the level of chemical messengers in the brain, which improves mood and physical symptoms of depression.

Nexola Plus Tablet may be taken with or without food. Take it at the same time each day, as this helps maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and do not miss a dose. This medication must not be stopped suddenly without talking to your doctor, as it may worsen your symptoms.

Some common side effects of this medicine include dryness in the mouth, weight gain, and disturbance in attention. It may also cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how this medicine affects you. However, these symptoms are temporary and usually resolve on their own. Please consult your doctor if these do not subside or bother you.

Before taking Nexola Plus Tablet, inform your doctor if you are suffering from thyroid or kidney disease, epilepsy, Parkinson’s disease, glaucoma, or any heart disease. You should not take this medicine if you are under the influence of alcohol or any sleep-inducing, coughing, or allergy medication. You should avoid alcohol while taking Nexola Plus Tablet, as it may worsen certain side effects.

Nexola Plus Tablet can also lead to weight gain, eat a healthy, balanced diet, avoid snacking with high-calorie food, and exercise regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.

Uses of Nexola Plus Tablet

Depression associated with Bipolar disorder

Benefits of Nexola Plus Tablet

In Depression associated with Bipolar disorder

Nexola Plus Tablet is used in the treatment for depression associated with bipolar disorder. It helps stabilize mood and improve overall well-being. It works by relieving persistent feelings of sadness and reducing emotional ups and downs. Nexola Plus Tablet helps in improving focus, sleep, and overall mental health. It offers a reliable option for those seeking better management of bipolar depression, allowing them to maintain a more balanced and fulfilling life.

Side effects of Nexola Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Nexola Plus

Weight gain
Dryness in mouth
Edema (swelling)
Difficulty in paying attention
Fatigue
Increased appetite
Sedation
Sleepiness
Blurred vision

How to use Nexola Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nexola Plus Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Nexola Plus Tablet works

Nexola Plus Tablet is a combination of two medicines: Fluoxetine and Olanzapine. They work by increasing the activity of certain chemicals called serotonin, norepinephrine, and dopamine in the brain. These chemicals help relieve the symptoms of depression associated with bipolar depression.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Nexola Plus Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Nexola Plus Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Nexola Plus Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Nexola Plus Tablet may cause side effects which could affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Nexola Plus Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Nexola Plus Tablet may not be needed in these patients. Please consult your doctor.

Liver

CAUTION

Nexola Plus Tablet should be used with caution in patients with liver disease. Dose adjustment of Nexola Plus Tablet may be needed. Please consult your doctor.

What if you forget to take Nexola Plus Tablet?

If you miss a dose of Nexola Plus Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Nexola Plus Tablet

₹9.5/Tablet

Fostera 20mg/5mg Tablet

Intas Pharmaceuticals Ltd

₹13.1/tablet

38% costlier

Oleanz Plus Tablet

Sun Pharmaceutical Industries Ltd

₹14.3/tablet

51% costlier

Olanex F Tablet

Emcure Pharmaceuticals Ltd

₹15.4/tablet

62% costlier

Oltha Plus Tablet

Shine Pharmaceuticals Ltd

₹12.5/tablet

32% costlier

Olay Plus Tablet

Talent India

₹10.7/tablet

13% costlier

View all substitutes

Quick tips

Take it in the evening, as Nexola Plus Tablet can make you feel sleepy.
It may take 4 to 6 weeks to experience the full benefits of the medication.
Do not drive or do anything requiring concentration until you know how it affects you.
It may cause an increase in weight, blood sugar, cholesterol, and triglycerides (fat). Eat healthy and exercise regularly.
Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.

Fact Box

Habit Forming

Therapeutic Class

NEURO CNS

Patient concerns

Treatment about bipolar disorder

Dr. Ravi Shankar M.

Ayurveda

Tab. Manasa Mitra Vataki 1-0-1 and Kalyanaka Ghritam 10 gram twice a day with luke warm wtar after food and Sarswatharishta 15 ml twice a day with equal quantity of water for 2 months

Suffering from bipolar disorder

Dr. Jyoti Kapoor Madan

Psychiatry

Bipolar Affective Disorder is a chronic problem caused by Neuro chemical disturbance in brain. It is characterised by excessive mood swings leading to disruption in routine life. Treatment is with mood stabilizer medicines and antipsychotic medicines which may need to continue throughout life. Please see a psychiatrist for further guidance.

Bipolar disorder treatment needed

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Olanzapine and fluoxetine hydrochloride [Prescribing Information]. Indianapolis, IN: Eli Lilly and Company; 2011. [Accessed 16 Sep. 2024] (online) Available from: