Nex 400mcg Injection

Naloxone (400mcg)

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Nex 400mcg Injection is an opioid antagonist. It is used for the treatment of opioid toxicity. It helps to reverse the depressant effect on breathing, and on other parts of the body. It also helps to determine if a patient has taken an overdose of opioids.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 29 Apr 2026 | 01:01 PM (IST)

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General Information

Contains

Naloxone (400mcg)

Marketer

Neon Laboratories Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Nex 400mcg Injection is given as an injection into veins, muscle, or under the skin by a doctor or nurse. It is advisable not to self-administer the injection. Your doctor or nurse will train your family member or caregiver about how to inject the medicine in case of an emergency. It is advisable to follow your doctor's advice while being on the treatment.

The most common side effects of this medicine include injection site redness, dizziness, headache and increased or decreased blood pressure. Most of these usually go away within a short time of the injection. If you are bothered by them or they go on for longer, talk to your doctor or nurse. You should not drive if this medicine makes you feel dizzy.

Before taking it, tell your doctor if you have heart problems, high blood pressure, or high heart rate. This may affect your treatment. Pregnant or breastfeeding women should consult their doctor before taking this medicine. Some other medicines you are taking may interfere with it, so make sure your doctor knows about all the other medicines you are using.

Uses of Nex Injection

Opioid toxicity

Benefits of Nex Injection

Opioid toxicity
Opioid toxicity or opioid overdose can be life-threatening and requires immediate medical attention. It is most commonly seen in people who take opioids containing painkillers or those who are indulged in drug abuse. Nex 400mcg Injection helps to reverse the effects of opioid toxicity such as reduced breathing, confusion, lessened alertness, and loss of consciousness.
Nex 400mcg Injection is given as an injection by a doctor or a nurse and should not be self-administered. If you are a caregiver to a person who is on opioids, you need to be trained well by a healthcare professional to administer Nex 400mcg Injection in case there is an emergency and you do not have access to medical services immediately.

Side effects of Nex Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Nex

Dizziness
Injection site redness
Decreased blood pressure
Headache
High blood pressure

How to use Nex Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Nex Injection works

Nex 400mcg Injection is an opioid antagonist. Opioid medicines are strong painkillers, which in high doses can cause life-threatening side effects such as difficulty in breathing. Nex 400mcg Injection works by blocking the effects of opioids leading to reversal of these side effects.

Quick tips

It is given as an injection into veins, muscle or under the skin by the healthcare professionals only.
Nex 400mcg Injection might make you feel dizzy. If this happens, avoid driving or operating on machinery.
Inform the doctor if you are taking any pain killers, sleeping pills (sedatives), narcotic painkillers, or other medicines
Avoid consuming alcohol while taking the medicine as it can affect the working of the medicine.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Nex 400mcg Injection. Please consult your doctor.

Pregnancy

SAFE IF PRESCRIBED

Nex 400mcg Injection is generally considered safe to use during pregnancy. Animal studies do not indicate harmful effects. However, there are limited human studies.

Breast feeding

SAFE IF PRESCRIBED

Available human data suggest that the drug does not pass into breast milk in clinically significant amounts and is unlikely to harm the infant.

Driving

UNSAFE

Nex 400mcg Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Nex 400mcg Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Nex 400mcg Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

What is Nex 400mcg Injection used for?

Nex 400mcg Injection is an emergency medicine used to rapidly reverse the life-threatening effects of an opioid overdose. It can quickly restore normal breathing in a person whose breathing has slowed down or stopped due to taking too many opioids.

How quickly does Nex 400mcg Injection start to work?

When given intravenously (IV), Nex 400mcg Injection works extremely fast, often within one to two minutes. If it is injected into a muscle (intramuscular) or under the skin (subcutaneous), it starts to work within about 2 to 5 minutes.

Where on the body should I give Nex 400mcg Injection?

For intramuscular auto-injectors of Nex 400mcg Injection, the best place to inject the medicine is into the middle of the outer thigh. You can even give the injection through clothing if you need to act quickly. Also, try to take the affected person to the hospital as soon as possible.

What happens if I give Nex 400mcg Injection to someone who has not taken opioids?

If you give Nex 400mcg Injection to someone who is unconscious for a reason other than an opioid overdose, it is unlikely to harm them. Since it is hard to be sure of the cause in an emergency, it is always safer to administer this medicine if an opioid overdose is suspected.

Will one dose of Nex 400mcg Injection be enough?

Sometimes, a single dose of Nex 400mcg Injection is not enough, or the person may respond and then relapse into respiratory depression. It may be necessary to give additional doses of this medicine every 2 to 3 minutes until emergency medical help arrives or the person is breathing normally again.

What should I do if the person does not wake up after Nex 400mcg Injection?

If the person does not respond to Nex 400mcg Injection, you must be prepared to perform other life-saving measures. This could include rescue breathing or starting CPR if you are trained to do so, while you wait for paramedics to arrive.

Fact Box

Chemical Class

Phenanthrenes derivatives

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Opioid Antagonists

Related lab tests

Opiates

References

Yaksh TL, WallaceIn MS. Opioids, Analgesia, and Pain Management. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 512.
Schumacher MA, Basbaum AI, Way WL. Opioids Analgesics & Antagonists. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 547-48.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 952-53.
Naloxone hydrochloride dihydrate. King William Street, London: Advanz Pharma; 1990 [revised 30 Aug. 2012]. [Accessed 6 Apr. 2019] (online) Available from:
Naloxone. Richmond: Kaleo, Inc.; 1971 [revised Apr. 2014]. [Accessed 6 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 6 Apr. 2019] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Neon Laboratories Ltd
Address: 140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.

Vendor Details

Country of origin: India

Lab tests offered by us

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