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MRP: Rs. 90 for 1 vial(s) (1 ML injection each)
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Composition for NEX(NEL)

Naloxone(400 mcg)

food interaction for NEX(NEL)

alcohol interaction for NEX(NEL)

pregnancy interaction for NEX(NEL)

lactation interaction for NEX(NEL)

It can be taken with or without food, but it is better to take Nex 400mcg injection at a fixed time.
Interaction with alcohol is unknown. Please consult your doctor.
Nex 400mcg injection is probably safe to use during pregnancy.
Either animal studies have shown no adverse effect on the fetus, but there is no human studies or animal studies have shown an adverse effect that was not confirmed in human studies. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Naloxone(400 mcg)


Nex 400mcg injection is used to treat opioid drug overdose, reverse respiratory depression caused by opioids in adults and in newborns (when the mother has been treated) and to diagnose acute opioid overdose or intoxication.

How it works

Nex 400mcg injection belongs to the class of drugs called opioid antagonists. It works by blocking the opioid receptors, does not let opioid drugs act and prevents or reverses the effects of opioids.

Common side effects

Restlessness, Nervousness, Palpitations, Body ache, Diarrhoea, Headache, Sweating, Hot flushes, Injection site burn, Injection site pain, Injection site redness, Nausea, Running nose, Shivering, Trembling, Sneezing, Stomach cramp, Tachycardia, Heart rate irregular, Vomiting, Yawning, Fever


2 Substitutes
Sorted By
    (1 ML injection in vial)
    Samarth Life Sciences Pvt Ltd
    Rs. 84/ML of injection
    Rs. 84
    save 7% more per ML of injection
    (1 ML injection in vial)
    Troikaa Pharmaceuticals Ltd
    Rs. 200/ML of injection
    Rs. 200
    pay 122% more per ML of injection

Expert advice for NEX(NEL)

  • Consult the doctor if you suffer from heart problems, fits (seizures), have a history of head injury or brain tumor, or if you are addicted to drugs or alcohol.
  • It is recommended not to drive or do any activity that requires alertness as naloxone impairs thinking or reaction.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.
  • Naloxone does not act against respiratory depression caused by drugs other than opioids.
  • Do not drink alcohol if you are taking naloxone.
  • Inform the doctor if you are taking any pain killers, sleeping pills (sedatives), narcotic painkillers, or other medicines.

Frequently asked questions for NEX(NEL)


Q. Is naloxone a controlled substance?
No. Naloxone is not a controlled substance.
Q. Is naloxone addictive?
No. Naloxone is not addictive.
Q. Is naloxone water soluble?
Yes. Naloxone is soluble in water.
Q. Is naloxone absorbed orally?
Yes. Naloxone is relatively well absorbed after oral administration. However, it undergoes extensive first-pass metabolism, making this route of delivery ineffective.
Q. Is naloxone in subutex?
No. Naloxone is not present in subutex.
Q. Does naloxone block tramadol?
No. naloxone does not block tramadol.
Q. Does naloxone cause constipation?
No. Naloxone does not cause constipation.
Q. Does naloxone reverse methadone?
Yes. Naloxone reverses the effects of methadone.
Q. Does naloxone reverse ketamine?
No. Naloxone does not reverse the effect of ketamine as it is an anaesthetic agent.
Q. Does naloxone block buprenorphine?
Naloxone does not block buprenorphine if it is taken in pill form, but when injected or snorted it will.


Content on this page was last updated on 22 April, 2014, by Dr. Varun Gupta (MD Pharmacology)