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Neosert Plus 0.5mg/25mg Tablet SR 1
Neosert Plus 0.5mg/25mg Tablet SR 2
Not for online sale

Neosert Plus 0.5mg/25mg Tablet SR

Alprazolam (0.5mg)+ Sertraline (25mg)
Genuine
Authenticity Assured
Prescription
required
Neosert Plus 0.5mg/25mg Tablet SR is a prescription medicine used to treat depression. It is a combination medicine which calms the brain by decreasing the abnormal and excessive activity of the nerve cells. It also increases the levels of some chemical messengers in the brain and improves mood.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 27 Oct 2026 | 05:04 PM (IST)
₹84.7 MRP ₹89.065% off 
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Neosert Plus 0.5mg/25mg Tablet SR 1
Neosert Plus 0.5mg/25mg Tablet SR 2

Product introduction

Neosert Plus 0.5mg/25mg Tablet SR is taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain consistent levels of medicine in the body. Take this medicine in the dose and duration advised by your doctor as it has habit-forming potential. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better. It is important not to stop taking this medicine suddenly as this may cause nausea, stomach upset, flu-like withdrawal symptoms, sleep disturbance and anxiety.

Some common side effects of this medicine include nausea, vomiting, diarrhea, confusion, memory impairment, and low sexual desire. It may also cause dizziness and sleepiness. So, do not drive or do anything that requires mental focus until you know how this medicine affects you. It may cause weight gain or weight loss depending upon person to person. To prevent weight gain, you can eat a healthy balanced diet, avoid snacking with high-calorie food and exercise regularly. On the other hand, weight loss can be managed by consulting a dietitian who can help you increase the food portions. It is important to inform your doctor if you develop any unusual changes in mood as it may cause suicidal thoughts.

Take caution while taking medicine if you are suffering from liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Uses of Neosert Plus Tablet SR

Benefits of Neosert Plus Tablet SR

Depression
Neosert Plus 0.5mg/25mg Tablet SR works by affecting the balance of certain chemicals (such as serotonin) in the brain. It helps improve mood and feelings of wellbeing, relieve anxiety and tension, helps you sleep better, and increase your energy level. It is an effective antidepressant but may cause drowsiness. You need to take it regularly as it is prescribed for it to be most effective and should not stop taking it suddenly.

Side effects of Neosert Plus Tablet SR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Neosert Plus
  • Nausea
  • Vomiting
  • Diarrhea
  • Confusion
  • Memory impairment
  • Uncoordinated body movements
  • Drowsiness
  • Tiredness
  • Delayed ejaculation
  • Anorgasmia (decreased orgasm)
  • Low sexual desire

How to use Neosert Plus Tablet SR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Neosert Plus 0.5mg/25mg Tablet SR may be taken with or without food.

How Neosert Plus Tablet SR works

Neosert Plus 0.5mg/25mg Tablet SR contains alprazolam and sertraline. Alprazolam enhances the action of GABA, a chemical messenger in the brain that helps calm excessive nerve activity and may help reduce anxiety. Sertraline increases the availability of serotonin, a chemical messenger involved in regulating mood and emotions. Together, they may help relieve anxiety symptoms and improve mood.

Quick tips

  • Neosert Plus 0.5mg/25mg Tablet SR is prescribed for the treatment of depression.
  • Inform your doctor immediately if you get thoughts about harming yourself or ending your life.
  • It is also advisable to inform your doctor if you get aggressive, anxiety, trouble sleeping, an increase in activity or talking more than what is normal for you, and other unusual changes in behavior or mood.
  • Do not stop taking Neosert Plus 0.5mg/25mg Tablet SR unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary.
  • Avoid the use of Neosert Plus 0.5mg/25mg Tablet SR along with certain medications like aspirin, warfarin, ibuprofen, or naproxen as it might increase the risk of bleeding.
  • Inform your doctor if you observe changes in appetite or weight.
  • Inform your doctor if you are taking any other antidepressant.
  • If you have diabetes, you will be asked to monitor your blood glucose level regularly as Neosert Plus 0.5mg/25mg Tablet SR may affect the levels of sugar in your blood.
  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Neosert Plus 0.5mg/25mg Tablet SR may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Neosert Plus 0.5mg/25mg Tablet SR is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Neosert Plus 0.5mg/25mg Tablet SR may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Neosert Plus 0.5mg/25mg Tablet SR may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Neosert Plus 0.5mg/25mg Tablet SR should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

UNSAFE
Neosert Plus 0.5mg/25mg Tablet SR is unsafe to use in patients with liver disease and should be avoided.
Use of Neosert Plus 0.5mg/25mg Tablet SR is not recommended in patients with severe liver disease.

Frequently asked questions

Neosert Plus 0.5mg/25mg Tablet SR may be used to manage depression and anxiety symptoms. Take it only as recommended by your doctor.
Yes, Neosert Plus 0.5mg/25mg Tablet SR can cause physical dependence and may lead to misuse or addiction, particularly with prolonged use or higher doses. Take it only as prescribed, do not increase the dose yourself, and attend follow-up appointments with your doctor.
No. Do not stop taking it suddenly without medical advice. Stopping alprazolam suddenly can cause withdrawal symptoms, which may include severe anxiety, sleep problems, and seizures. Stopping sertraline suddenly can also cause withdrawal symptoms. Your doctor will advise how to reduce the dose gradually if treatment needs to end.
Tell your doctor about all medicines you take. Sleeping pills, sedatives, opioid pain medicines, and other medicines that cause drowsiness can increase the sedative effects of alprazolam. Some combinations may cause dangerously slow breathing. Do not combine these medicines unless your doctor has specifically assessed the risks.
Neosert Plus 0.5mg/25mg Tablet SR may increase the risk of bleeding, particularly when taken with medicines such as aspirin, ibuprofen, naproxen, warfarin, or other blood thinners. Inform your doctor before using these medicines and seek medical advice if you notice unusual bruising or bleeding.
Yes. Neosert Plus 0.5mg/25mg Tablet SR may cause reduced sexual desire, delayed ejaculation, or difficulty reaching orgasm. Tell your doctor if these effects persist or affect your quality of life. Do not stop treatment on your own.
Contact your doctor promptly if you develop worsening depression, unusual agitation, aggression, or major changes in sleep or behaviour. If you have thoughts of harming yourself or ending your life, or feel you may act on them, seek emergency medical help immediately.

Fact Box

Habit Forming

Yes

Therapeutic Class

NEURO CNS
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100% genuine products
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Definer Pharmaceuticals Pvt Ltd
Address: 554/172/7 CHHOTA BARAHA LUCKNOW Lucknow UP 226005 IN

Vendor Details

Country of origin: India
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