


Neosert Plus 0.5mg/25mg Tablet SR
Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 27 Oct 2026 | 05:04 PM (IST)

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Product introduction
Neosert Plus 0.5mg/25mg Tablet SR is taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain consistent levels of medicine in the body. Take this medicine in the dose and duration advised by your doctor as it has habit-forming potential. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better. It is important not to stop taking this medicine suddenly as this may cause nausea, stomach upset, flu-like withdrawal symptoms, sleep disturbance and anxiety.
Some common side effects of this medicine include nausea, vomiting, diarrhea, confusion, memory impairment, and low sexual desire. It may also cause dizziness and sleepiness. So, do not drive or do anything that requires mental focus until you know how this medicine affects you. It may cause weight gain or weight loss depending upon person to person. To prevent weight gain, you can eat a healthy balanced diet, avoid snacking with high-calorie food and exercise regularly. On the other hand, weight loss can be managed by consulting a dietitian who can help you increase the food portions. It is important to inform your doctor if you develop any unusual changes in mood as it may cause suicidal thoughts.
Take caution while taking medicine if you are suffering from liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Uses of Neosert Plus Tablet SR
Benefits of Neosert Plus Tablet SR
Neosert Plus 0.5mg/25mg Tablet SR works by affecting the balance of certain chemicals (such as serotonin) in the brain. It helps improve mood and feelings of wellbeing, relieve anxiety and tension, helps you sleep better, and increase your energy level. It is an effective antidepressant but may cause drowsiness. You need to take it regularly as it is prescribed for it to be most effective and should not stop taking it suddenly.
Side effects of Neosert Plus Tablet SR
- Nausea
- Vomiting
- Diarrhea
- Confusion
- Memory impairment
- Uncoordinated body movements
- Drowsiness
- Tiredness
- Delayed ejaculation
- Anorgasmia (decreased orgasm)
- Low sexual desire
How to use Neosert Plus Tablet SR
How Neosert Plus Tablet SR works
Quick tips
- Neosert Plus 0.5mg/25mg Tablet SR is prescribed for the treatment of depression.
- Inform your doctor immediately if you get thoughts about harming yourself or ending your life.
- It is also advisable to inform your doctor if you get aggressive, anxiety, trouble sleeping, an increase in activity or talking more than what is normal for you, and other unusual changes in behavior or mood.
- Do not stop taking Neosert Plus 0.5mg/25mg Tablet SR unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary.
- Avoid the use of Neosert Plus 0.5mg/25mg Tablet SR along with certain medications like aspirin, warfarin, ibuprofen, or naproxen as it might increase the risk of bleeding.
- Inform your doctor if you observe changes in appetite or weight.
- Inform your doctor if you are taking any other antidepressant.
- If you have diabetes, you will be asked to monitor your blood glucose level regularly as Neosert Plus 0.5mg/25mg Tablet SR may affect the levels of sugar in your blood.
- Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver
Use of Neosert Plus 0.5mg/25mg Tablet SR is not recommended in patients with severe liver disease.
Frequently asked questions
Fact Box
Habit Forming
Therapeutic Class
References
- Alprazolam. Sandwich, Kent: Pfizer Limited; 1982 [revised Jan. 2019]. [Accessed 22 Apr. 2019] (online) Available from:
- Sertaline. New York, New York: Pfizer; 2014. [Accessed 23 Apr. 2019] (online) Available from:
- Alprazolam. Kalamazoo, Michigan: Pharmacia & Upjohn Company. [Accessed 22 Apr. 2019] (online) Available from:
- Sertaline. Beverley, Hull: Dr. Reddy's Laboratories (UK) Ltd.; 2008 [revised 18 Apr. 2018]. [Accessed 23 Apr. 2019] (online) Available from:
- Alprazolam [Prescribing Information]. American Health Packaging; 2024. [Accessed 12 Oct 2026]. Available from:
- Sertraline hydrochloride [Prescribing Information]. Accord Healthcare, Inc.; 2025. [Accessed 12 Oct 2026]. Available from:
- Sertraline: an antidepressant medicine. NHS, 8 Sep 2025. [Accessed 12 Oct 2026]. Available from:




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- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- PPBS (Postprandial Blood Sugar)
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid -19 test- RT PCR
- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
- Vitamin B12
- CRP (C-Reactive Protein), Quantitative
- Urine C/S (Urine Culture and Sensitivity)
- Serum Electrolytes
- Serum Calcium
- Serum Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)















