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MRP: Rs. 343.57 for 1 vial(s) (10 ML injection each)
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Composition for MITOZAN

Mitoxantrone(20 mg)

food interaction for MITOZAN

alcohol interaction for MITOZAN

pregnancy interaction for MITOZAN

lactation interaction for MITOZAN

It can be taken with or without food, but it is better to take it at a fixed time.
Avoid it with grapefruit juice.
Interaction with alcohol is unknown. Please consult your doctor.
It is unsafe to use during pregnancy.
Human and animal studies have shown adverse effects on the foetus. The potential benefits may warrant the use in pregnant women despite potential risks. Please consult your doctor.
It is probably unsafe to use during breastfeeding. Please consult your doctor.


Mitoxantrone(20 mg)


Mitozan 20mg injection is used to treat breast cancer that has spread to other parts of the body, non-Hodgkin's lymphoma (tumors that develop from lymphocytes, a type of white blood cell) and adult acute non-lymphocytic leukemia (a quickly progressive malignant disease in which there are too many immature blood-forming cells in the blood and bone marrow). It is also used as second line therapy in the treatment of advanced prostate cancer and in certain patients with multiple sclerosis [disease in which the immune system attacks the protective sheath (myelin) that covers the nerves].

How it works

Mitozan 20mg injection is an antineoplastic agent that belongs to the class of drugs known as topoisomerase inhibitors. It interferes with cell reproduction and growth, which helps reduce the number of cancer cells in the body.

Common side effects

Decreased urination, Pain in urinary bladder, Pale colored skin, Petechiae (red or purple spot caused by bleeding into the skin), Back pain, Bruise, Bleeding, Blood in stool, Blood in urine, Burning sensation, Convulsion, Cough, Shortness of breath, Dizziness, Difficulty in urination, Fainting, Fatigue, Weakness, Frequent urge to urinate, Altered heart rate, Limb swelling, Mouth inflammation, Mouth swelling, Eye redness, Sore, Sores, Stomach pain, Tarry stools, Ulcer, White spots in the mouth, Yellow discoloration of skin, Yellow discoloration of eye, Chills, Fever


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Expert advice for MITOZAN

  • Mitoxantrone may turn your urine to a blue-green color and the whites of your eyes to a bluish color; this is not of a cause of concern.
  • Avoid contact with people who have colds or infections as mitoxantrone may lower the ability of your body to fight infections. 
  • Do not receive a live vaccine (eg, measles, mumps) while you are using mitoxantrone.
  • Avoid activities that may cause bruising or injury as mitoxantrone may reduce the number of clot-forming cells (platelets) in your blood making you more susceptible to bleeding. Seek immediate medical attention if you have unusual bruising or bleeding or if you have dark, tarry, or bloody stools.
  • Take precautions by staying hydrated especially if vomiting or diarrhea occurs.
  • Ensure that cardiac monitoring is regularly performed and blood counts are taken at frequent intervals prior, during, and post therapy. 
  • Tell your doctor of any relevant medical history, especially of blood/bleeding disorders (e.g., anemia, low blood cell counts), heart disease (e.g., congestive heart failure, irregular heartbeat), liver disease, radiation treatment, recent/current infection.

Frequently asked questions for MITOZAN


Q. Is mitoxantrone an anthracycline/ a DNA binding vesicant/ a vesicant?
Mitoxantrone is not a vesicant. It is an anthracenedione (derivatives of anthraquinone) having antineoplastic   properties.
Q. Is mitoxantrone a chemotherapy?
Mitoxantrone   is an antineoplastic or anti-cancer chemotherapy agent .
Q. How is mitoxantrone administered?
Mitoxantrone is administered as an intravenous injection.
Q. How does mitoxantrone help multiple sclerosis?
Mitoxantrone will not cure multiple sclerosis (MS), but is effective in slowing the progression of secondary progressive MS and extending the time between relapses in relapsing-remitting MS and progressive relapsing MS.


Content on this page was last updated on 17 July, 2014, by Dr. Varun Gupta (MD Pharmacology)