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Mitoxantrone is used in the treatment of non-hodgkin's lymphoma, breast cancer and blood cancer

How it works

Mitoxantrone works by damaging the genetic material (DNA) of the cancer cells and stops their growth and multiplication.

Common side effects

Decreased urination, Pain in urinary bladder, Pale colored skin, Petechiae (red or purple spot caused by bleeding into the skin), Back pain, Bruise, Bleeding, Blood in stool, Blood in urine, Burning sensation, Convulsion, Cough, Shortness of breath, Dizziness, Difficulty in urination, Fainting, Fatigue, Weakness, Frequent urge to urinate, Altered heart rate, Limb swelling, Mouth inflammation, Mouth swelling, Eye redness, Sore, Sores, Stomach pain, Tarry stools, Ulcer, White spots in the mouth, Yellow discoloration of skin, Yellow discoloration of eye, Chills, Fever

Available Medicine

Expert advice

  • Mitoxantrone may turn your urine to a blue-green color and the whites of your eyes to a bluish color; this is not of a cause of concern.
  • Avoid contact with people who have colds or infections as mitoxantrone may lower the ability of your body to fight infections. 
  • Do not receive a live vaccine (eg, measles, mumps) while you are using mitoxantrone.
  • Avoid activities that may cause bruising or injury as mitoxantrone may reduce the number of clot-forming cells (platelets) in your blood making you more susceptible to bleeding. Seek immediate medical attention if you have unusual bruising or bleeding or if you have dark, tarry, or bloody stools.
  • Take precautions by staying hydrated especially if vomiting or diarrhea occurs.
  • Ensure that cardiac monitoring is regularly performed and blood counts are taken at frequent intervals prior, during, and post therapy. 
  • Tell your doctor of any relevant medical history, especially of blood/bleeding disorders (e.g., anemia, low blood cell counts), heart disease (e.g., congestive heart failure, irregular heartbeat), liver disease, radiation treatment, recent/current infection.

Frequently asked questions


Q. Is mitoxantrone an anthracycline/ a DNA binding vesicant/ a vesicant?
Mitoxantrone is not a vesicant. It is an anthracenedione (derivatives of anthraquinone) having antineoplastic properties

Q. Is mitoxantrone a chemotherapy?
Mitoxantrone is an antineoplastic or anti-cancer chemotherapy agent

Q. How is mitoxantrone administered?
Mitoxantrone is administered as an intravenous injection

Q. How does mitoxantrone help multiple sclerosis?
Mitoxantrone will not cure multiple sclerosis (MS), but is effective in slowing the progression of secondary progressive MS and extending the time between relapses in relapsing-remitting MS and progressive relapsing MS.

Content on this page was last updated on 13 January, 2017, by Dr. Varun Gupta (MD Pharmacology)