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Mitoxantrone

Information

Uses

Mitoxantrone is used in the treatment of non-hodgkin's lymphoma, breast cancer and blood cancer

How it works

Mitoxantrone works by damaging the genetic material (DNA) of the cancer cells and stops their growth and multiplication.

Common side effects

Reduced blood platelets, Mouth swelling, Blood in stool, Joint pain, Headache, Dizziness, Fainting, Sores, Back pain, Convulsion, Tarry stools, Interstitial pneumonia, Nail pigmentation, Pain in urinary bladder, Decreased urination, Pulmonary fibrosis, Frequent urge to urinate, Eye redness, Nail discoloration, Muscle pain, Haemorrhage, Shortness of breath, Ulcer, Pale colored skin, Yellow discoloration of eye, Vomiting, Weakness, Altered heart rate, Sore, White spots in the mouth, Musculoskeletal pain, Nausea, Abdominal pain, Infection, Glossitis, Loss of appetite, Lip inflammation, Decreased white blood cell count, Yellow discoloration of skin, Hair loss, Absence of menstrual periods, Fatigue, Fever, Anemia, Stomach pain, Bleeding, Chills, Blood in urine, Mouth inflammation, Diarrhoea, Rigors, Burning sensation, Hypersensitivity, Petechiae (red or purple spot caused by bleeding into the skin), Feeling of discomfort, Cough, Weight loss, Altered taste, Febrile neutropenia, Peripheral sensory neuropathy, Decreased white blood cell count (neutrophils), Bruise, Difficulty in urination, Constipation, Hand-foot syndrome, Neuropathy, Stomatitis, Nail disorder, Infusion reaction, Limb swelling, Oral ulcer, Breathing difficulty

Available Medicine

  • ₹467
    Sun Pharmaceutical Industries Ltd
    1 variant(s)
  • ₹461
    Intas Pharmaceuticals Ltd
    1 variant(s)
  • ₹343
    Vhb Life Sciences Inc
    1 variant(s)

Expert advice

  • Mitoxantrone may turn your urine to a blue-green color and the whites of your eyes to a bluish color; this is not of a cause of concern.
  • Avoid contact with people who have colds or infections as mitoxantrone may lower the ability of your body to fight infections. 
  • Do not receive a live vaccine (eg, measles, mumps) while you are using mitoxantrone.
  • Avoid activities that may cause bruising or injury as mitoxantrone may reduce the number of clot-forming cells (platelets) in your blood making you more susceptible to bleeding. Seek immediate medical attention if you have unusual bruising or bleeding or if you have dark, tarry, or bloody stools.
  • Take precautions by staying hydrated especially if vomiting or diarrhea occurs.
  • Ensure that cardiac monitoring is regularly performed and blood counts are taken at frequent intervals prior, during, and post therapy. 
  • Tell your doctor of any relevant medical history, especially of blood/bleeding disorders (e.g., anemia, low blood cell counts), heart disease (e.g., congestive heart failure, irregular heartbeat), liver disease, radiation treatment, recent/current infection.

Frequently asked questions

Mitoxantrone

Q.

Is mitoxantrone an anthracycline/ a DNA binding vesicant/ a vesicant?
Mitoxantrone is not a vesicant. It is an anthracenedione (derivatives of anthraquinone) having antineoplastic properties

Q.

Is mitoxantrone a chemotherapy?
Mitoxantrone is an antineoplastic or anti-cancer chemotherapy agent

Q.

How is mitoxantrone administered?
Mitoxantrone is administered as an intravenous injection

Show More
Q.

How does mitoxantrone help multiple sclerosis?
Mitoxantrone will not cure multiple sclerosis (MS), but is effective in slowing the progression of secondary progressive MS and extending the time between relapses in relapsing-remitting MS and progressive relapsing MS.


Content on this page was last updated on 15 February, 2017, by Dr. Varun Gupta (MD Pharmacology)