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Composition for METOZ R

Ramipril(5 mg),Metolazone(2.5 mg)

food interaction for METOZ R

alcohol interaction for METOZ R

pregnancy interaction for METOZ R

lactation interaction for METOZ R

There is no data available. Please consult doctor before consuming the drug.
Taking Metolazone with alcohol may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate.
Metoz r tablet is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Metoz r tablet is probably safe to use during breastfeeding. Please consult your doctor.


Ramipril(5 mg)


Ramipril is mainly used to control high blood pressure (hypertension). It is used to treat heart failure, to improve survival after heart attack and to prevent stroke. Ramipril is also used to treat various kidney diseases.

How it works

Ramipril belongs to a class of drugs called ACE inhibitors (angiotensin converting enzyme inhibitors), Ramipril inhibits the chemical ACE (angiotensin converting enzyme). As a result, there is relaxation of blood vessels leading to a fall in blood pressure which makes it easier for the heart to pump blood.

Common side effects

Allergic reaction, Cough, Dizziness, Difficulty in swalloing, Shortness of breath, Facial swelling, Generalised swelling, Headache, Vomiting, Stomach upset
Metolazone(2.5 mg)


Metolazone is used to reduce edema (swelling and fluid retention) due to congestive heart failure and kidney diseases. It is also used alone or in combination for the treatment of high blood pressure.

How it works

Metolazone belongs to the group of medicines called quinazoline (thiazide-like) diuretic. It acts by reducing salt and water in the body by increasing the urination.

Common side effects

Nausea, Nerve injury, Orthostatic hypotension (low blood pressure), Palpitations, Petechiae (red or purple spot caused by bleeding into the skin), Increased sensitivity to light, Abdominal bloating, Acute gouty attacks, Joint pain, Blood vessel inflammation, Blurred vision, Bone marrow failure, Chest discomfort, Chest pain, Chills, Constipation, Dehydration, Depression, Diarrhoea, Dizziness, Drowsiness, Gastrointestinal discomfort, Fainting, Fatigue, Bleeding gums, Headache, Inflammation of liver, Pancreatic inflammation, Increased glucose level in blood, Increased uric acid level in blood, Impotence, Increased blood urea nitrogen, Increased creatine level in blood, Increased glucose in urine, Insomnia, Jaundice, Loss of appetite, Muscle cramp, Rash, Restlessness, Tarry stools, Unpleasant breath odour, Vertigo, Vomiting, Weakness, Abnormal sensation in skin, Decreased potassium level in blood, Decreased white blood cell count


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Expert advice for METOZ R

  • Do not take ramipril with any other product containing aliskiren if you are diabetic or have kidney problems.
  • Do not take ramipril if you have narrowing of one or both arteries that carry blood to kidneys causing reduced blood flow to the kidneys (bilateral renal artery stenosis or renal artery stenosis in a single functioning kidney), abnormally low or unstable blood pressure.
  • Do not consume if you are undergoing dialysis or any blood filtration technique as ramipril may cause sudden and severe reactions. 
  • Discontinue ramipril and consult your doctor if you suffer from cough or swelling of eyes and lips (angioedema).
  • Before taking ramipril, consult your doctor if you are suffering from severe increase in blood pressure, have worsening of symptoms of pre-existing heart failure (decompensated heart failure).

Frequently asked questions for METOZ R


Q. Is ramipril a diuretic?
No, ramipril is not a diuretic It belongs to a class of drugs called ACE inhibitors (angiotensin converting enzyme inhibitors), mainly used to reduce high blood pressure.
Q. Is ramipril safe?
Ramipril is safe if used at prescribed doses for the prescribed duration as advised by your doctor.
Q. Is ramipril or cardace a calcium channel blocker/alpha blocker/ beta blocker?
No, ramipril or cardace is an ACE inhibitor and shows no known effects on calcium channels or alpha receptors or beta receptors.
Q. Is ramipril a nitrate or a statin?
Ramipril is neither a nitrate nor a statin. It is an ACE inhibitor used to treat high blood pressure.
Q. What are Cardace / Ramistar/Hopace used for?
Cardace, Ramistar, Hopace are all trade names for the active drug ramipril. Ramipril is an ACE inhibitor used to treat high blood pressure.
Q. Can I take ramipril with simvastatin/amlodipine/ Viagra/naproxen/prednisolone/ metformin/ Sudafed (pseudoephedrine-decongestant preparation)?
There are no known serious drug interactions between ramipril when taken with simvastatin/ amlodipine/ Viagra/naproxen/prednisolone/ metformin/Sudafed. However, consult your doctor about all medications currently taken before starting and while on ramipril.
Q. Can I take ramipril with ibuprofen?
Ibuprofen can be taken with ramipril, however, it is known that ibuprofen and other NSAIDs may reduce the antihypertensive effects of ramipril. Consult your doctor about any medications currently taken before starting and while on ramipril.
Q. Does ramipril cause coughing?
Yes, non-productive tickling cough, is one of the common side effects or ramipril.
Q. Does ramipril cause frequent urination?
No, ramipril has no known effect on increasing the frequency of urination. It may rarely increase the urine output but not affect the frequency of urination.
Q. Does ramipril cause itching?
Yes, ramipril may cause itching of skin. It is not very commonly observed.
Q. Does ramipril cause an increase in potassium levels in the blood?
Yes, increased potassium levels is one a common side effects of ramipril.
Q. Does ramipril cause depression?
Yes, ramipril may cause depression; however, it is not very commonly observed.
Q. Does ramipril thin the blood?
No. ramipril has no known effect on blood thinning.
Q. Is ramipril available in India?
Yes, ramipril is available in India with more than 100 brand names.


Q. Is metolazone potassium sparing diuretic/ loop diuretic/ beta blocker/ steroid/narcotic?
Metolazone belongs to the group of medicines called quinazoline and thiazide-like diuretic and it is not potassium sparing diuretic/ loop diuretic/ beta blocker/ steroid/narcotic.
Q. Is metolazone discontinued?
No, metolazone is not discontinued.
Q. Is metolazone stronger than Lasix?
Metolazone and furosemide (Lasix) belongs to same category of drugs (diuretics), but their effect may vary upon individual response.
Q. Can you take metolazone with Lasix?
Metolazone and furosemide (Lasix) may sometimes be prescribed, but these combinations can lead to dehydration and electrolyte abnormalities. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Q. Does metolazone contain sulfa?
Yes, it contains sulfa. Chemically it is called as 7-chloro-2-methyl-4-oxo-3-o-tolyl-1, 2, 3, 4-tetrahydroquinazoline-6-sulfonamide.
Q. Does metolazone get you high/ deplete potassium?
Metolazone causing the above side effects is uncommon or rare. However consult your doctor if you experience any of these side effects.
Q. Does metolazone appear in breast milk?
Yes, metolazone gets excreted in breast milk. Patient should follow the advice of the doctor regarding its use.
Q. How long does metolazone take to work?
It depends upon disease condition and lot of other factors. Patient should follow the advice of the doctor regarding its use.


Content on this page was last updated on 01 February, 2016, by Dr. Varun Gupta (MD Pharmacology)