


Metolactone 2.5 mg/50 mg Tablet
Metolazone (2.5mg)+ Spironolactone (50mg)
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Metolactone 2.5 mg/50 mg Tablet is a combination of two medicines used to treat hypertension (high blood pressure). It reduces the excess fluid levels in your body while maintaining potassium balance.
Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 02 Sep 2026 | 03:40 PM (IST)
Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 02 Sep 2026 | 03:40 PM (IST)
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General Information
Contains
Metolazone (2.5mg)+ Spironolactone (50mg)
Marketer
Centaur Pharmaceuticals Pvt Ltd
Storage
Store below 30°C
The content is shown in English



Product introduction
It is best to take Metolactone 2.5 mg/50 mg Tablet in the morning along with food in order to avoid frequent urination at night time. For better results, it is suggested to take it at the same time every day. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you.
Diarrhea, stomach upset, and glucose intolerance are very common side effect of this medicine. It might lower down the electrolytes level like sodium, potassium, and magnesium in the blood. Hence, regular monitoring of kidney function, blood pressure, and electrolytes are important while using this medicine. It might cause dizziness or tiredness if happens rise slowly from sitting position or avoid driving.
Before taking this medicine, tell your doctor if you have any liver or kidney disease. Inform your doctor if you are pregnant. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by this medicine.
Diarrhea, stomach upset, and glucose intolerance are very common side effect of this medicine. It might lower down the electrolytes level like sodium, potassium, and magnesium in the blood. Hence, regular monitoring of kidney function, blood pressure, and electrolytes are important while using this medicine. It might cause dizziness or tiredness if happens rise slowly from sitting position or avoid driving.
Before taking this medicine, tell your doctor if you have any liver or kidney disease. Inform your doctor if you are pregnant. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by this medicine.
Uses of Metolactone Tablet
Benefits of Metolactone Tablet
Hypertension (high blood pressure)
Metolactone 2.5 mg/50 mg Tablet relaxes the blood vessels so that blood can flow more easily around your body. It also eliminates excess water from the body and increases urine output. This maintains balance of electrolytes (like potassium), lowers your blood pressure and reduces your risk of having a stroke, a heart attack, or kidney problems in the future. You do not usually feel any direct benefit from taking this medicine, but it works in the long term to keep you well. You should take it regularly as prescribed for this medicine to be most effective, even if you feel better.
Metolactone 2.5 mg/50 mg Tablet relaxes the blood vessels so that blood can flow more easily around your body. It also eliminates excess water from the body and increases urine output. This maintains balance of electrolytes (like potassium), lowers your blood pressure and reduces your risk of having a stroke, a heart attack, or kidney problems in the future. You do not usually feel any direct benefit from taking this medicine, but it works in the long term to keep you well. You should take it regularly as prescribed for this medicine to be most effective, even if you feel better.
Side effects of Metolactone Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Metolactone
- Diarrhea
- Upset stomach
- Glucose intolerance
- Breast enlargement in male
- Irregular menstrual cycle
- Increased blood lipid level
- Increased uric acid level in blood
- Electrolyte imbalance
- Impotence
How to use Metolactone Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Metolactone 2.5 mg/50 mg Tablet should be taken with or after food.
How Metolactone Tablet works
Metolactone 2.5 mg/50 mg Tablet is a combination of two diuretics: Metolazone and Spironolactone.
Quick tips
- You have been prescribed Metolactone 2.5 mg/50 mg Tablet for the treatment of high blood pressure.
- Monitor your blood pressure after starting Metolactone 2.5 mg/50 mg Tablet and notify your doctor if it does not lower down.
- Your doctor may get regular tests done to monitor the level of urea and lipid in your blood.
- Metolactone 2.5 mg/50 mg Tablet helps you to lose water via urination. If, however, you lose too much fluid, you may become dehydrated. This will make you feel thirsty and make your skin look and feel dry. Let your doctor know if this happens, as your dose may need to be adjusted.
- Avoid taking anti-inflammatory medicines such as Ibuprofen along with this medicine without consulting your doctor.
- Lifestyle changes like a low-sodium diet, exercise, and not smoking may help this medicine work better.
Safety advice

Alcohol
CAUTION
Alcohol should be used with caution while taking Metolactone 2.5 mg/50 mg Tablet.

Pregnancy
CONSULT YOUR DOCTOR
Metolactone 2.5 mg/50 mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding
CONSULT YOUR DOCTOR
Metolactone 2.5 mg/50 mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving
UNSAFE
Metolactone 2.5 mg/50 mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
As Metolactone 2.5 mg/50 mg Tablet may cause drowsiness, dizziness, blurred vision, or lightheadedness and this may affect your ability to drive.
As Metolactone 2.5 mg/50 mg Tablet may cause drowsiness, dizziness, blurred vision, or lightheadedness and this may affect your ability to drive.

Kidney
CAUTION
Metolactone 2.5 mg/50 mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Use of Metolactone 2.5 mg/50 mg Tablet is not recommended in patients with severe kidney disease.
Use of Metolactone 2.5 mg/50 mg Tablet is not recommended in patients with severe kidney disease.

Liver
CAUTION
Metolactone 2.5 mg/50 mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.
Fact Box
Habit Forming
No
Therapeutic Class
CARDIAC
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
Marketer details
Name: Centaur Pharmaceuticals Pvt Ltd
Address: CENTAUR HOUSE, Near Grand Hyatt, Vakola ,Santacruz – East, Mumbai – 400 055, India.
Address: CENTAUR HOUSE, Near Grand Hyatt, Vakola ,Santacruz – East, Mumbai – 400 055, India.
Vendor Details
Country of origin: India
Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- PPBS (Postprandial Blood Sugar)
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid -19 test- RT PCR
- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
- Vitamin B12
- CRP (C-Reactive Protein), Quantitative
- Urine C/S (Urine Culture and Sensitivity)
- Serum Electrolytes
- Serum Calcium
- Serum Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)
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