Content Details
Written By
MDS (Oral Pathology & Microbiology), BDS
Reviewed By
MD (Pharmacology), MBBS
Last updated on:
20 Aug 2019 | 04:55 PM (IST)
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Mepal 150mg/1500mcg Tablet


Overview

Introduction

Mepal 150mg/1500mcg Tablet is a medicine used in the treatment of diabetic nerve disease. It protects the nerve fibers from damage and promotes regeneration of nerve cells. It is used along with other blood sugar lowering medications in order to prevent further nerve injury.

Uses of Mepal Tablet

Mepal Tablet side effects

Common
  • Nausea
  • Vomiting
  • Increased liver enzymes

How to use Mepal Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Mepal 150mg/1500mcg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Mepal Tablet works

Mepal 150mg/1500mcg Tablet is a combination of two medicines: Epalrestat and methylcobalamin which treat diabetic nerve disease. Epalrestat is an aldose reductase inhibitor. It blocks the accumulation of sorbitol in cells, which has been related in causing diabetic nerve disease. Methylcobalamin is a form of vitamin B which helps in the production of myelin, a substance that protects nerve fibers and rejuvenates damaged nerve cells.

Mepal Tablet related warnings

Alcohol
Interaction with alcohol is unknown. Please consult your doctor.
Pregnancy
WEIGH RISKS VS BENEFITS
Mepal 150mg/1500mcg Tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Lactation
No information is available on the use of Mepal 150mg/1500mcg Tablet during lactation. Please consult your doctor.
Driving
It is not known whether Mepal 150mg/1500mcg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney
There is limited information available on the use of Mepal 150mg/1500mcg Tablet in patients with kidney disease. Please consult your doctor.
Liver
There is limited information available on the use of Mepal 150mg/1500mcg Tablet in patients with liver disease. Please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
No alternate brands found for this medicine

Expert Advice

  • Take it only as per the dose and duration prescribed by your doctor. 
  • Adherence to antidiabetic therapy can delay the onset of or prevent diabetic nerve disease.
  • Inform your doctor if you have:
    • Cut or sore on your feet that is infectious or not healing
    • Burning or tingling sensation in arm or feet that hamper your routine activities
    • Trouble in digestion, urination, or sexual functioning
    • Dizziness
  • To prevent diabetic nerve pain, wear proper footwear and examine your feet every day to detect lesions early.
  • Monitor your blood sugar level regularly.
  • Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Patient Concerns

Questions Related to Mepal

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Nerve Pain from outer left knee radiating towards ankle. Consulted a neurologist who advised to conduct x-ray of knee,spine, advised to take gabapin 100mg twice daily along with thyronorm 25mg. Also advised to consult rheumatologist. Neurologist has seen blood test report which show +ve ANA, High TSH (7.58). Hb1ac, uric acid, vit d3, b12 normal range.Also accompanied by pain in knee area for past 2 monthsHas difficulty walking, standing up from sitting position. Would like to have second opinion whether to go for NCV test advised by neurologist and start taking the medications prescribed.
Dr. Vikas Sharma
Neurologist
Better to get ncv done Take medicine
Dear doctor my left leg planter middle area very pain and two legs burning sir. May be dought nerve pain doctor All reports attached here doctor
Dr. Vikas Sharma
Neurologist
Show to Orthopedic Start tab tryptomer 10 mg bd Apply local heat
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Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Sharma SR, Sharma N. Epalrestat, an aldose reductase inhibitor, in diabetic neuropathy: An Indian perspective. Ann Indian Acad Neurol. 2008;11(4):231-35. [Accecssed 08 Apr. 2019] (online) Available from:External Link
  2. National Institues of Health. Vitamin B12. [Accessed 08 Apr. 2019] (online) Available from:External Link
  3. Hotta N, Akanuma Y, Kawamori R, et al. Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial. Diabetes Care. 2006;29(7):1538-44. [Accessed 08 Apr. 2019] (online) Available from:External Link
Manufacturer/Marketer Address
KMS Health Center Pvt. Ltd., "SONA TOWERS" No : 10 A&B, Dr.Rajendra Prasad Road, Hasthinapuram, Chrompet, Chennai - 600044, Tamilnadu , India.
A licensed pharmacy from your nearest location will deliver Mepal 150mg/1500mcg Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your prescription and the availability of this medicine.
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