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Megatas Plus 50 Combikit

Written By Dr. Lipika Khurana, PGDHHM, BDS
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS
Last updated on 07 Apr 2026 | 02:54 PM (IST)
Megatas Plus 50 Combikit is a combination of two medicines used in the treatment of the symptoms of an overactive bladder. It relieves urinary symptoms like frequent urination, urgent need to urinate and inability to control urination.
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Megatas Plus 50 Combikit image
Megatas Plus 50 Combikit image
Megatas Plus 50 Combikit image
Megatas Plus 50 Combikit image

Product introduction

Megatas Plus 50 Combikit is advised to be taken in the dose and duration as prescribed by your doctor. It may be taken with or without food, preferably at the same time each day. You should not stop taking the medicine without consulting the doctor as it may lead to the worsening of your symptoms. The course of the treatment should be completed for better efficacy of the medicine.

There is limited data on the side effects of Megatas Plus 50 Combikit. Let your doctor know if you experience any symptoms while taking the medicine. They may be able to suggest ways to treat or manage the side effects.

Before receiving the treatment, inform your doctor if you are on any medication for any other health condition. If you are pregnant or breastfeeding, tell your doctor prior to the treatment. People with liver or kidney disease must be cautious while receiving the prescription and they must receive regular follow-ups as per the doctor’s advice.

Uses of Megatas Plus Kit

Benefits of Megatas Plus Kit

Overactive bladder (OAB)
Megatas Plus 50 Combikit helps to treat uncontrollable contractions (spasms) of the bladder muscles that cause frequent urination, urgent need to urinate, and inability to control passing of urine. It also relieves painful, or frequent urination and reduces urgency to urinate that may occur with some infections of the urinary tract. This way it helps manage the overactive bladder symptoms efficiently.

Side effects of Megatas Plus Kit

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Megatas Plus
  • Limited data available

How to use Megatas Plus Kit

Take this medicine in the dose and duration as advised by your doctor. Check the label before use. Megatas Plus 50 Combikit may be taken with or without food.

How Megatas Plus Kit works

Megatas Plus 50 Combikit is a combination of two medicines: Mirabegron and Solifenacin. Mirabegron is a beta 3-receptor agonist. It works by activating the receptor in the bladder, causing the bladder muscles to relax. Solifenacin is an antimuscarinic. It also works by relaxing muscles of the urinary bladder. In this way, it works to prevent frequent, urgent, or uncontrolled urge of urination.

Quick tips

  • Megatas Plus 50 Combikit helps you to have better control over your urination.
  • It may raise your blood pressure. Monitor your blood pressure regularly.
  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress and review your treatment.
  • Avoid caffeine (tea, coffee, cola, etc.) as it is a natural diuretic (increased urine production) and will make your symptoms worse.
  • Avoid drinking too much water before going to bed as it will increase your urge to go to the toilet and thus disturb your sleep.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Megatas Plus 50 Combikit. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Megatas Plus 50 Combikit is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CAUTION
Megatas Plus 50 Combikit should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

UNSAFE
Megatas Plus 50 Combikit may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Megatas Plus 50 Combikit should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

UNSAFE
Megatas Plus 50 Combikit is unsafe to use in patients with liver disease and should be avoided.

Frequently asked questions

Megatas Plus 50 Combikit is used to treat overactive bladder (OAB). The symptoms include an urgent need to urinate, frequent urination, and urge incontinence (urine leaks). This medicine helps you control urination better and reduce the sudden urge to pass urine.
People should not take Megatas Plus 50 Combikit if they have ever had an allergy to Mirabegron, Solifenacin, or any ingredient in the medicine. It is also not recommended for patients with severe, uncontrolled high blood pressure or if they are unable to empty their bladder completely (urinary retention).
Yes, Megatas Plus 50 Combikit can raise your blood pressure. Your doctor will likely check your blood pressure regularly, and this medicine is not suitable if you have uncontrolled severe hypertension.
Yes, Megatas Plus 50 Combikit causes problems with urine flow, especially in people with bladder outlet obstruction or those already on other medicines for an overactive bladder. This medicine may increase the risk of difficulty passing urine or acute urinary retention. Report any problems with urination right away.
Seek medical care for symptoms of serious side effects of Megatas Plus 50 Combikit, such as swelling of the face, lips, tongue, or throat, trouble breathing, or hives. Also, very rapid heartbeat, severe constipation, confusion, or sudden loss of vision should be reported immediately.
Megatas Plus 50 Combikit may affect the heart rhythm. The risk increases if you already take other medicines that affect the heart or have existing rhythm disturbances. Always tell your doctor if you have a heart condition.

Fact Box

Habit Forming

No

Therapeutic Class

UROLOGY

References

  1. Brown JH, Brandl K, Wess J. Muscarinic Receptor Agonists and Antagonists. In: Brunton LL, Hilal-Dandan R, Knollmann BC (Editors). Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 13th ed. New York, NY: McGraw-Hill Education; 2018. pp. 149-161.
  2. Pappano AJ. Cholinoceptor-Blocking Drugs. In: Katzung BG, Masters SB, Trevor AJ (Editors). Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 113-126.
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User feedback

Overactive bladder (OAB) symptoms
100%
Excellent
67%
Average
33%
No Side Effect
100%
Empty stomach
100%
Expensive
67%
Average
33%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Vendor Details

Country of origin: India
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