Megamentin Injection

Amoxycillin (1000mg)+ Clavulanic Acid (200mg)

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Megamentin Injection is a penicillin-type of antibiotic that helps your body fight infections caused by bacteria. It is used to treat infections of the lungs (e.g., pneumonia), ear, nasal sinus, urinary tract, skin, and soft tissue. It will not work for viral infections such as the common cold.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 29 Apr 2026 | 01:02 PM (IST)

₹111 MRP ₹126.6112% off

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Oneclav 1000 mg/200 mg Injection

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Megamentin Injection

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Same composition

Oneclav 1000 mg/200 mg Injection

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Amoxycillin (1000mg) + Clavulanic Acid (200mg)

by Lupin Ltd

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General Information

Contains

Amoxycillin (1000mg)+ Clavulanic Acid (200mg)

Marketer

Intas Pharmaceuticals Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Megamentin Injection is generally administered by a healthcare professional and should not be self-administered. Depending on the severity of your underlying illness, your doctor will decide the precise dose and schedule as per which this injection is to be given. It is strictly advised to be used as per the doctor’s prescription.

Common side effects of this medicine include nausea, vomiting, diarrhea, and thrush. Additionally, you may notice some injection site reactions like pain, swelling, or redness. Please consult your doctor if these do not get better or persist for a longer duration of time. In cases of patients with severe liver or kidney disease, consult your doctor before you start with the treatment.

Before using it, you should tell your doctor if you are allergic to any antibiotics or have any kidney or liver problems. Your doctor may change the dose or prescribe a different medicine. This medicine is generally regarded as safe to use during pregnancy and breastfeeding if used under a doctor’s supervision.

Uses of Megamentin Injection

Prophylaxis of surgery associated Bacterial infections

Benefits of Megamentin Injection

Prophylaxis of surgery associated Bacterial infections
Megamentin Injection contains two different medicines, Amoxycillin and Clavulanic Acid, that work together to kill the bacteria that cause infections. Amoxycillin works by stopping the growth of bacteria. Clavulanic Acid reduces resistance and enhances the activity of Amoxycillin against bacteria.

This combination medicine can be used in the prophylaxis of surgery associated bacterial infections such as gastrointestinal tract, pelvic cavity, head and neck, biliary tract surgery. It usually makes you feel better within a few days, but you should continue taking it as prescribed even when you feel better to make sure that all bacteria are killed and do not become resistant.

Side effects of Megamentin Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Megamentin

Vomiting
Nausea
Diarrhea
Thrush

How to use Megamentin Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Megamentin Injection works

Megamentin Injection is a combination of two medicines: Amoxycillin and Clavulanic Acid. Amoxycillin is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Clavulanic Acid is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Amoxycillin against bacteria.

All substitutes for Megamentin Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

You have been prescribed this combination medicine to treat bacterial infections even if they have developed resistance.
Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
Diarrhea may occur as a side effect. Taking probiotics along with Megamentin Injection may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.
Stop taking Megamentin Injection and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.
Do not use leftover medicine for treating any infection in the future. Always consult your doctor before taking any antibiotic.

Safety advice

Alcohol

SAFE

Consuming alcohol with Megamentin Injection does not usually cause any harmful side effects.

Pregnancy

SAFE IF PRESCRIBED

Megamentin Injection is generally considered safe to use during pregnancy. Animal studies do not indicate harmful effects. However, there are limited human studies.

Breast feeding

SAFE IF PRESCRIBED

Available human data suggest that the drug does not pass into breast milk in clinically significant amounts and is unlikely to harm the infant.

Driving

UNSAFE

Megamentin Injection may cause side effects that could affect your ability to drive.
Megamentin Injection may cause side effects such as allergic reactions, dizziness or fits that may make you unfit to drive.

Kidney

CAUTION

Megamentin Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Use of this medicine is not recommended in patients with severe kidney disease.

Liver

CAUTION

Megamentin Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.
Regular monitoring of liver function tests is recommended while you are taking this medicine

Frequently asked questions

What is Megamentin Injection?

Megamentin Injection is a combination of two medicines: Amoxycillin and Clavulanic acid. It is used to treat bacterial infections like, tonsillitis, sinusitis, otitis media, respiratory tract infections, urinary tract infections, boils, abscesses, cellulitis, wound infection, bone infection, and oral cavity infections.. The medicine works by killing the harmful bacteria that cause infections.

Is it safe to use Megamentin Injection?

Megamentin Injection is safe to use when taken as advised by the doctor. However, in some patients, it may cause common side effects like diarrhea, nausea, vomiting, rash, allergic reaction and other uncommon or rare side effects. If you experience any persistent problem during the course of your treatment, inform your doctor as soon as possible.

How is Megamentin Injection administered?

Megamentin Injection should be administered under the supervision of a trained healthcare professional or a doctor only and should not be self-administered. The dose will depend on the condition you are being treated for and will be decided by your doctor. Follow your doctor’s instructions carefully to get maximum benefit from Megamentin Injection.

Are there any specific cautions associated with the use of Megamentin Injection?

The use of Megamentin Injection is considered to be harmful for patients with known allergy to penicillins or any other ingredient of the medicine. It should not be used in patients with a history of liver disease. Therefore, inform your doctor if you are allergic to any medicines.

Can the use of Megamentin Injection cause contraceptive failure?

Yes, the use of Megamentin Injection can lower the efficacy of birth control pills. Consult your doctor and seek advice regarding the use of other methods of contraception (e.g., condom, diaphragm, spermicide) while you are taking Megamentin Injection.

Can I take a higher than the recommended dose of Megamentin Injection?

No, taking a higher than the recommended dose of Megamentin Injection can increase the risks of side effects. Megamentin Injection takes time to show its full effect and treat your infection. If you are experiencing increased severity of your symptoms, please consult your doctor for re-evaluation.

What are the instructions for the storage and disposal of Megamentin Injection?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose off the unused medicine. Make sure it is not consumed by pets, children and other people.

Can Megamentin Injection cause an allergic reaction?

Yes, Megamentin Injection can cause an allergic reaction. It is considered to be harmful for patients with known allergy to penicillins. Get emergency medical help if you have any signs of allergic reaction like hives, difficulty breathing, or swelling of your face, lips, tongue or throat.

Can the use of Megamentin Injection cause diarrhea?

Yes, the use of Megamentin Injection can cause diarrhea. It is an antibiotic which kills the harmful bacteria. In addition to that, the medicine may affect the helpful bacteria in your stomach or intestine as well and cause diarrhea. In case you experience diarrhea, drink plenty of water or other fluids. Talk to your doctor if diarrhea persists and you notice any signs of dehydration, like less frequency of urination with dark colored and strong-smelling urine. Do not take any other medicine without consulting a doctor.

Fact Box

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Megamentin Injection

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Megamentin Injection

Benefits of Megamentin Injection

Side effects of Megamentin Injection

How to use Megamentin Injection

How Megamentin Injection works

All substitutes for Megamentin Injection

Novamox CV 1.2gm Injection

Joeclav 1000mg/200mg Injection

Zenimox-CV Injection

Twicillin 1000mg/200mg Injection

Ulticlav 1000 mg/200 mg Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Megamentin Injection?

Is it safe to use Megamentin Injection?

How is Megamentin Injection administered?

Are there any specific cautions associated with the use of Megamentin Injection?

Can the use of Megamentin Injection cause contraceptive failure?

Can I take a higher than the recommended dose of Megamentin Injection?

What are the instructions for the storage and disposal of Megamentin Injection?

Can Megamentin Injection cause an allergic reaction?

Can the use of Megamentin Injection cause diarrhea?

Fact Box

Habit Forming

Therapeutic Class

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests